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KATP channels as molecular sensors of cellular metabolism
TLDR
In responding to cytoplasmic nucleotide levels, ATP-sensitive potassium (KATP) channel activity provides a unique link between cellular energetics and electrical excitability, which has led to detailed structural and kinetic models that define the molecular basis of channel activity.
Potassium channel block by cytoplasmic polyamines as the mechanism of intrinsic rectification
TLDR
The results suggest that intrinsic rectification results from voltage-dependent block of the channel pore by polyamines, not from a voltage sensor intrinsic to the channel protein.
Membrane phospholipid control of nucleotide sensitivity of KATP channels.
TLDR
It is proposed that membrane-incorporated PIPs can bind to positive charges in the cytoplasmic region of the KATP channel's Kir6.2 subunit, stabilizing the open state of the channel and antagonizing the inhibitory effect of ATP.
Distinct macrophage lineages contribute to disparate patterns of cardiac recovery and remodeling in the neonatal and adult heart
TLDR
It is shown that distinct macrophage populations derived from embryonic and adult lineages are important determinants of tissue repair and inflammation, respectively, and suggests that therapeutics targeting distinctMacrophage lineages may serve as novel treatments for heart failure.
Cloning and expression of an inwardly rectifying ATP-regulated potassium channel
TLDR
A complementary DNA encoding an ATP-regulated potassium channel has been isolated by expression cloning from rat kidney and the presence of an H5 region, which is likely to form the ion conduction pathway, indicates that the protein may share a common origin with voltage-gated potassium channel proteins.
Structure of a bacterial voltage-gated sodium channel pore reveals mechanisms of opening and closing
TLDR
The open structure of a sodium-gated ion channel pore from a bacterial homologue is reported and it is shown, by comparison with the closed structure, that the movement of a C-terminal helix is sufficient to open the channel.
Muscle KATP channels: recent insights to energy sensing and myoprotection.
TLDR
Genetically modified animals give important insights to likely pathological roles of aberrant channel activity in different muscle types and the regulation and role of muscle K(ATP) channels.
Adenosine Diphosphate as an Intracellular Regulator of Insulin Secretion
TLDR
By binding to SUR NBF2 and antagonizing ATP inhibition of KATP channels, intracellular MgADP may regulate insulin secretion.
Inward rectifier potassium channels.
The past three years have seen remarkable progress in research on the molecular basis of inward rectification, with significant implications for basic understanding and pharmacological manipulation
Adenosine triphosphate-sensitive potassium channels in the cardiovascular system.
TLDR
Evidence is presented in support of the idea that variations of [ATP] i and [ADP]i, even within normal concentration ranges, may influence cellular function in the heart and vascular system via a direct action on the KATP channel.
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