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KATP channels as molecular sensors of cellular metabolism
In responding to cytoplasmic nucleotide levels, ATP-sensitive potassium (KATP) channel activity provides a unique link between cellular energetics and electrical excitability. Over the past tenExpand
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Cloning of the beta cell high-affinity sulfonylurea receptor: a regulator of insulin secretion.
Sulfonylureas are a class of drugs widely used to promote insulin secretion in the treatment of non-insulin-dependent diabetes mellitus. These drugs interact with the sulfonylurea receptor ofExpand
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Potassium channel block by cytoplasmic polyamines as the mechanism of intrinsic rectification
INWARDLY rectifying potassium channels conduct ions more readily in the inward than the outward direction, an essential property for normal electrical activity1,2. Although voltage-dependent block byExpand
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Membrane phospholipid control of nucleotide sensitivity of KATP channels.
Adenosine triphosphate (ATP)-sensitive potassium (KATP) channels couple cell metabolism to electrical activity. Phosphatidylinositol phosphates (PIPs) profoundly antagonized ATP inhibition of KATPExpand
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Distinct macrophage lineages contribute to disparate patterns of cardiac recovery and remodeling in the neonatal and adult heart
Significance This study addresses a fundamentally important and widely debated issue in the field of inflammation, which is why inflammation can be simultaneously deleterious after injury and yet isExpand
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Structure of a bacterial voltage-gated sodium channel pore reveals mechanisms of opening and closing
Sodium-gated ion channels open and close in response to the flow of ions. Here, McCusker et al. report the open structure of a sodium-gated ion channel pore from a bacterial homologue, and show, byExpand
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Cloning and expression of an inwardly rectifying ATP-regulated potassium channel
A complementary DNA encoding an ATP-regulated potassium channel has been isolated by expression cloning from rat kidney. The predicted 45K protein, which features two potential membrane-spanningExpand
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Muscle KATP channels: recent insights to energy sensing and myoprotection.
ATP-sensitive potassium (K(ATP)) channels are present in the surface and internal membranes of cardiac, skeletal, and smooth muscle cells and provide a unique feedback between muscle cell metabolismExpand
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International Union of Pharmacology. LIV. Nomenclature and Molecular Relationships of Inwardly Rectifying Potassium Channels
Since the initial cDNA cloning of the first inward rectifiers Kir1.1 (ROMK1) and Kir2.1 (IRK1) in 1993, a succession of new members of this family have been identified, including the GExpand
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Cryo-EM and X-ray structures of TRPV4 reveal insight into ion permeation and gating mechanisms
The transient receptor potential (TRP) channel TRPV4 participates in multiple biological processes, and numerous TRPV4 mutations underlie several distinct and devastating diseases. Here we presentExpand
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