Sti1 and Cdc37 can stabilize Hsp90 in chaperone complexes with a protein kinase.

Abstract

Hsp90 functions in association with several cochaperones for folding of protein kinases and transcription factors, although the relative contribution of each to the overall reaction is unknown. We assayed the role of nine different cochaperones in the activation of Ste11, a Saccharomyces cerevisiae mitogen-activated protein kinase kinase kinase. Studies on… (More)

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