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Transmural Dispersion of Repolarization in Failing and Nonfailing Human Ventricle
TLDR
This work presents for the first time direct experimental evidence of a transmural APD gradient in the human heart and results in the heterogeneous prolongation of APD, which significantly reduces the transmural and local APD gradients. Expand
Optical Imaging of the Heart
TLDR
A critical overview of current approaches, their contributions to the field of cardiac electrophysiology, and future directions of various optical imaging modalities as applied to cardiac physiology at organ and tissue levels is provided. Expand
Mechanisms of cardiac and renal dysfunction in patients dying of sepsis.
TLDR
Cell death is rare in sepsis-induced cardiac dysfunction, but cardiomyocyte injury occurs, and the degree of cell injury and death does not account for severity of sepsi-induced organ dysfunction. Expand
Postganglionic nerve stimulation induces temporal inhibition of excitability in rabbit sinoatrial node.
TLDR
Optically mapping revealed that PNS resulted in transient loss of pacemaker cell excitability and unidirectional entrance conduction block in the periphery of SAN, indicating that the properties of the myocytes themselves, as well as intercellular coupling, must play a role in the inexcitability induction. Expand
Application of blebbistatin as an excitation-contraction uncoupler for electrophysiologic study of rat and rabbit hearts.
TLDR
Blebbistatin is a promising novel selective excitation-contraction uncoupler that can be used for optical imaging of cardiac tissues. Expand
Conduction Remodeling in Human End-Stage Nonischemic Left Ventricular Cardiomyopathy
TLDR
Conduction disorder resulting from the anisotropic downregulation of CX43 expression, the reduction of Cx43 phosphorylation, and increased fibrosis is likely to be a critical component of arrhythmogenic substrate in patients with nonischemic cardiomyopathy. Expand
Virtual electrode-induced phase singularity: a basic mechanism of defibrillation failure.
TLDR
This work sought to determine whether the VEP may be responsible for defibrillation failure by creating dispersion of postshock repolarization and reentry, and found that shock-induced VEPs may reinduce arrhythmias via a phase-singularity mechanism. Expand
Oxidized CaMKII causes cardiac sinus node dysfunction in mice.
TLDR
A computational model of the sinoatrial node showed that a loss of SAN cells below a critical threshold caused SND by preventing normal impulse formation and propagation, and suggested that targeted CaMKII inhibition may be useful for preventing SND in high-risk patients. Expand
Computer Three-Dimensional Reconstruction of the Sinoatrial Node
TLDR
For the first time, a 3D anatomically detailed mathematical model of the sinoatrial node has been constructed, and this shows the presence of a specialized interface between the SAN and atrial muscle. Expand
Transmural Heterogeneity and Remodeling of Ventricular Excitation-Contraction Coupling in Human Heart Failure
TLDR
For the first time, direct experimental evidence of transmural heterogeneity of excitation-contraction coupling and calcium handling in human hearts is presented and it is shown that end-stage heart failure is associated with the heterogeneous remodeling of excitement-contracted coupling andcium handling. Expand
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