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ABCC4 wt Allele

Known as: Canalicular Multispecific Organic Anion Transporter (ABC Superfamily) Gene, ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 4 wt Allele, MOAT-B 
Human ABCC4 wild-type allele is located in the vicinity of 13q32 and is approximately 282 kb in length. This allele, which encodes multidrug… 
National Institutes of Health

Related topics

Related topics

8 relations
13q32Homo sapiensIonophore activityLigand Binding

Broader (1)

ABCC4 gene

Narrower (1)

Multidrug Resistance-Associated Protein 4

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
Calculus Bovis Sativus up-regulates hepatic protein 2 (Mrp2) and Mrp4 in 17α-ethynylestradiol-induced cholestasis via a regulatory effect on ER signaling.
OBJECTIVE To investigate the pathway through which Calculus Bovis Sativus (CBS) up-regulates hepatic multidrug resistance… 
2018
2018
Impact of Multidrug Resistance Protein-4 Inhibitors on Modulating Platelet Function and High on-Aspirin Treatment Platelet Reactivity
Abstract Platelet multidrug resistance protein 4 (MRP4) plays a modulating role on platelet activation. Platelet function and… 
2018
2018
Disposition of Mianserin and Cyclizine in UGT2B10-Overexpressing Human Embryonic Kidney 293 Cells: Identification of UGT2B10 as a Novel N-Glucosidation Enzyme and Breast Cancer Resistance Protein as…
UDP-glucuronosyltransferases (UGTs) play an important role in the metabolism and detoxification of amine-containing chemicals… 
2015
2015
Stable knock-down of efflux transporters leads to reduced glucuronidation in UGT1A1-overexpressing HeLa cells: the evidence for glucuronidation-transport interplay.
Efflux of glucuronide is facilitated by the membrane transporters including BCRP and MRPs. In this study, we aimed to determine… 
2014
2014
Aspirin influences megakaryocytic gene expression leading to up-regulation of multidrug resistance protein-4 in human platelets
Aim The aim of the study was to investigate whether human megakaryocytic cells have an adaptive response to aspirin treatment… 
2009
2009
Unimpaired immune functions in the absence of Mrp4 (Abcc4).
2008
2008
Celecoxib upregulates multidrug resistance proteins in colon cancer: lack of synergy with standard chemotherapy.
Recent phase II randomised trials in colorectal cancer failed to demonstrate any advantage of celecoxib combined with standard… 
Highly Cited
2003
Highly Cited
2003
Loss of Multidrug Resistance Protein 1 Expression and Folate Efflux Activity Results in a Highly Concentrative Folate Transport in Human Leukemia Cells*
We studied the molecular basis of the up to 46-fold increased accumulation of folates and methotrexate (MTX) in human leukemia… 
Highly Cited
2001
Highly Cited
2001
Differential sensitivities of the MRP gene family and gamma-glutamylcysteine synthetase to prooxidants in human colorectal carcinoma cell lines with different p53 status.
2001
2001
Association between expression of the MRP3 gene and exposure to platinum drugs in lung cancer
To investigate the roles played by the multidrug resistance‐associated protein (MRP1) homologues MRP3 and MRP4 in resistance to… 
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