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New serum indicator of interstitial pneumonitis activity. Sialylated carbohydrate antigen KL-6.
Serum levels of a high molecular weight circulating antigen KL-6, detected by means of a sandwich assay using a monoclonal antibody KL-6 against a sialylated carbohydrate antigen, were evaluated for… Expand
Comparative study of KL-6, surfactant protein-A, surfactant protein-D, and monocyte chemoattractant protein-1 as serum markers for interstitial lung diseases.
- H. Ohnishi, A. Yokoyama, +5 authors N. Kohno
- American journal of respiratory and critical care…
- 1 February 2002
KL-6, surfactant protein (SP)-A, SP-D, and monocyte chemoattractant protein-1 (MCP-1) are reported to be sensitive markers for interstitial lung diseases (ILD). However, each marker has been studied… Expand
Increases of amphiregulin and transforming growth factor-alpha in serum as predictors of poor response to gefitinib among patients with advanced non-small cell lung cancers.
Serum levels of amphiregulin and transforming growth factor-alpha (TGF-alpha), which were identified previously to be expressed at high levels in non-small cell lung cancer (NSCLC) with poor response… Expand
Detection of soluble tumor-associated antigens in sera and effusions using novel monoclonal antibodies, KL-3 and KL-6, against lung adenocarcinoma.
- N. Kohno, M. Akiyama, S. Kyoizumi, M. Hakoda, K. Kobuke, M. Yamakido
- Japanese journal of clinical oncology
- 1 September 1988
Two novel monoclonal antibodies, KL-3 (IgM) and KL-6 (IgG1), which can detect soluble antigens in sera and effusions (molecular weights greater than 1,000 K) were produced against human pulmonary… Expand
Effectiveness of Semmes-Weinstein monofilament examination for diabetic peripheral neuropathy screening.
- N. Kamei, K. Yamane, +7 authors N. Kohno
- Journal of diabetes and its complications
- 28 January 2004
OBJECTIVE To evaluate the effectiveness of the Semmes-Weinstein monofilament examination (SWME) for diabetic peripheral neuropathy (DPN) screening at an outpatient clinic. METHODS Eighty-two type 2… Expand
Prospective versus retrospective ECG-gated 64-detector coronary CT angiography: assessment of image quality, stenosis, and radiation dose.
PURPOSE To show that prospective electrocardiographically (ECG)-triggered coronary computed tomographic (CT) angiography (hereafter, prospective CT angiography) is at least as effective as… Expand
Polymorphisms in the thymidylate synthase and methylenetetrahydrofolate reductase genes and sensitivity to the low-dose methotrexate therapy in patients with rheumatoid arthritis.
- K. Kumagai, K. Hiyama, T. Oyama, H. Maeda, N. Kohno
- Medicine, Biology
- International journal of molecular medicine
- 1 May 2003
Methotrexate (MTX), widely used in the treatment of rheumatoid arthritis (RA), inhibits dihydrofolate reductase (DHFR) and folate-dependent enzymes. Thymidylate synthase (TS) and… Expand
Utility of KL-6/MUC1 in the clinical management of interstitial lung diseases.
Interstitial lung diseases (ILDs) are a diverse group of pulmonary disorders characterized by various patterns of inflammation and fibrosis in the interstitium of the lung. Because injury and/or… Expand
Identification of nectin-4 oncoprotein as a diagnostic and therapeutic target for lung cancer.
Gene expression profile analysis of lung cancers revealed the transactivation of an immunoglobulin-like molecule Nectin-4 in the majority of non-small cell lung cancers (NSCLC). Immunohistochemical… Expand
Increased plasma ghrelin level in lung cancer cachexia.
- Y. Shimizu, N. Nagaya, +6 authors N. Kohno
- Clinical cancer research : an official journal of…
- 1 February 2003
PURPOSE Ghrelin, a novel growth hormone-releasing peptide,has been shown to cause a positive energy balance by stimulating food intake and inducing adiposity. We sought to investigate the… Expand