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ABCC4 gene

Known as: ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 4 Gene, MRP4, MULTISPECIFIC ORGANIC ANION TRANSPORTER B 
This gene plays a role in both cellular detoxification and platelet degranulation.
National Institutes of Health

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ABCC4 wt Allele
Homo sapiensIonophore activityLigand BindingMolecular Transport

Papers overview

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Review
2008
Review
2008
Multidrug resistance protein 4 (MRP4/ABCC4): a versatile efflux transporter for drugs and signalling molecules.
Highly Cited
2007
Highly Cited
2007
Functional Involvement of Multidrug Resistance-Associated Protein 4 (MRP4/ABCC4) in the Renal Elimination of the Antiviral Drugs Adefovir and Tenofovir
Acyclic nucleotide phosphonates (adefovir, cidofovir, and tenofovir) are eliminated predominantly into the urine, and renal… 
Highly Cited
2004
Highly Cited
2004
Mrp4 Confers Resistance to Topotecan and Protects the Brain from Chemotherapy
ABSTRACT The role of the multidrug resistance protein MRP4/ABCC4 in vivo remains undefined. To explore this role, we generated… 
Highly Cited
2004
Highly Cited
2004
The nucleotide transporter MRP4 (ABCC4) is highly expressed in human platelets and present in dense granules, indicating a role in mediator storage.
Platelet aggregation is initiated by the release of mediators as adenosine diphosphate (ADP) stored in platelet granules… 
Highly Cited
2003
Highly Cited
2003
The human multidrug resistance protein MRP4 functions as a prostaglandin efflux transporter and is inhibited by nonsteroidal antiinflammatory drugs
Prostaglandins are involved in a wide variety of physiological and pathophysiological processes, but the mechanism of… 
Highly Cited
2003
Highly Cited
2003
Characterization of the transport of nucleoside analog drugs by the human multidrug resistance proteins MRP4 and MRP5.
The human multidrug resistance proteins MRP4 and MRP5 are organic anion transporters that have the unusual ability to transport… 
Highly Cited
2002
Highly Cited
2002
Analysis of methotrexate and folate transport by multidrug resistance protein 4 (ABCC4): MRP4 is a component of the methotrexate efflux system.
Human MRP4 (ABCC4, MOAT-B) is a lipophilic anion transporter that is able to confer resistance to nucleotide analogues and… 
Highly Cited
2001
Highly Cited
2001
Correlation of gene expression of ten drug efflux proteins of the ATP-binding cassette transporter family in normal human jejunum and in human intestinal epithelial Caco-2 cell monolayers.
This investigation describes the expression and interindividual variability in transcript levels of multiple drug efflux systems… 
Highly Cited
2000
Highly Cited
2000
Analysis of the MRP4 drug resistance profile in transfected NIH3T3 cells.
BACKGROUND Multidrug resistance-associated protein (MRP) 1 and canalicular multispecific organic anion transporter (cMOAT or MRP2… 
Highly Cited
1997
Highly Cited
1997
Analysis of expression of cMOAT (MRP2), MRP3, MRP4, and MRP5, homologues of the multidrug resistance-associated protein gene (MRP1), in human cancer cell lines.
By screening databases of human expressed sequence tags, we have identified three new homologues of MRP1, the gene encoding the… 
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