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ABCC4 gene

Known as: ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 4 Gene, MRP4, MULTISPECIFIC ORGANIC ANION TRANSPORTER B 
This gene plays a role in both cellular detoxification and platelet degranulation.
National Institutes of Health

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ABCC4 wt Allele
Homo sapiensIonophore activityLigand BindingMolecular Transport

Papers overview

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2020
2020
Tanshinone IIA attenuates acetaminophen-induced hepatotoxicity through HOTAIR-Nrf2-MRP2/4 signaling pathway.
2018
2018
Release of Platelet-Derived Sphingosine-1-Phosphate Involves Multidrug Resistance Protein 4 (MRP4/ABCC4) and Is Inhibited by Statins
Abstract Sphingosine-1-phosphate (S1P) is a potent lipid mediator released from activated platelets by an adenosine triphosphate… 
2016
2016
Enhanced platelet MRP4 expression and correlation with platelet function in patients under chronic aspirin treatment
Summary Platelet multidrug resistance protein4 (MRP4)-overexpression has a role in reducing aspirin action. Aspirin in vivo… 
2015
2015
MRP4 Modulation of the Guanylate Cyclase-C/cGMP Pathway: Effects on Linaclotide-Induced Electrolyte Secretion and cGMP Efflux
MRP4 mediates the efflux of cGMP and cAMP and acts as an important regulator of these secondary messengers, thereby affecting… 
2014
2014
Characterization of Zebrafish Abcc4 as an Efflux Transporter of Organochlorine Pesticides
DDT and lindane are highly toxic organochlorine pesticides and posing adverse effects on the environment and public health due to… 
2012
2012
Reduction of cAMP and cGMP inhibitory effects in human platelets by MRP4-mediated transport
Summary Cyclic nucleotide-dependent inhibition of platelets represents the most important physiological way to limit thrombus… 
2011
2011
Genome-wide linkage and association mapping identify susceptibility alleles in ABCC4 for Kawasaki disease
Background Kawasaki disease (KD) is a self limited vasculitis in which host genetics plays a prominent role. To further the… 
2011
2011
The multidrug resistance-associated protein 4 (MRP4) appears as a functional carrier of prostaglandins regulated by oxytocin in the bovine endometrium.
Prostaglandins (PG) are involved in several female reproductive processes, and their action is regulated at the levels of… 
2008
2008
Effects of drug efflux proteins and topoisomerase I mutations on the camptothecin analogue gimatecan
SummaryClinically relevant resistance to the currently approved camptothecins, irinotecan and topotecan, is poorly understood but… 
1999
1999
MRP 3 , an organic anion transporter able to transport anti-cancer drugs ( multidrug resistance y methotrexate y etoposide )
The human multidrug-resistance protein (MRP) gene family contains at least six members: MRP1, encoding the multidrug-resistance… 
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