ABCC4 gene

Known as: ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 4 Gene, MRP4, MULTISPECIFIC ORGANIC ANION TRANSPORTER B 
This gene plays a role in both cellular detoxification and platelet degranulation.
National Institutes of Health

Papers overview

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Highly Cited
2011
Highly Cited
2011
Increased intracellular cAMP concentration plays a well established role in leukemic cell maturation. We previously reported that… (More)
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2008
2008
ABCC4 encodes multidrug resistance protein 4 (MRP4), a member of the ATP-binding cassette family of membrane transporters… (More)
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Highly Cited
2006
Highly Cited
2006
BACKGROUND Tenofovir disoproxil fumarate (TDF) may induce renal proximal tubulopathy (rPT). There are no data on pharmacogenomic… (More)
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Highly Cited
2006
Highly Cited
2006
Acyclic nucleotide phosphonates (adefovir, cidofovir, and tenofovir) are eliminated predominantly into the urine, and renal… (More)
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Highly Cited
2005
Highly Cited
2005
The end product of human purine metabolism is urate, which is produced primarily in the liver and excreted by the kidney through… (More)
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Highly Cited
2004
Highly Cited
2004
Platelet aggregation is initiated by the release of mediators as adenosine diphosphate (ADP) stored in platelet granules… (More)
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Highly Cited
2004
Highly Cited
2004
Chemoresistance is a major obstacle for successful treatment of cancer. To identify regions of the genome associated with… (More)
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Highly Cited
2003
Highly Cited
2003
The human multidrug resistance proteins MRP4 and MRP5 are organic anion transporters that have the unusual ability to transport… (More)
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Highly Cited
2002
Highly Cited
2002
Human MRP4 (ABCC4, MOAT-B) is a lipophilic anion transporter that is able to confer resistance to nucleotide analogues and… (More)
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Highly Cited
1997
Highly Cited
1997
By screening databases of human expressed sequence tags, we have identified three new homologues of MRP1, the gene encoding the… (More)
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