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Multidrug Resistance-Associated Protein 4

Known as: ABCC4, Multi-Specific Organic Anion Transporter B, MOAT-B 
Multidrug resistance-associated protein 4 (1325 aa, ~150 kDa) is encoded by the human ABCC4 gene. This protein plays a role in platelet degranulation… 
National Institutes of Health

Related topics

Related topics

18 relations
ABCC4 geneAdenosine TriphosphatasesCellular MembraneDrug Efflux

Broader (1)

ABCC4 wt Allele

Papers overview

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2016
2016
Genome-wide rare copy number variation screening in ulcerative colitis identifies potential susceptibility loci
BackgroundUlcerative colitis (UC), a complex polygenic disorder, is one of the main subphenotypes of inflammatory bowel disease… 
2012
2012
Effects of culture duration on gene expression of P450 isoforms, uptake and efflux transporters in primary hepatocytes cultured in the absence and presence of interleukin-6: implications for…
We report here a comprehensive evaluation of the effects of culture duration on the gene expression of P450 isoforms, uptake… 
2011
2011
Genome-wide linkage and association mapping identify susceptibility alleles in ABCC4 for Kawasaki disease
Background Kawasaki disease (KD) is a self limited vasculitis in which host genetics plays a prominent role. To further the… 
2005
2005
Determination of phase I metabolic enzyme activities in liver microsomes of Mrp2 deficient TR- and EHBR rats.
2004
2004
Effects of Organic Anions and Bile Acid Conjugates on Biliary Excretion of Pravastatin in the Rat
AbstractPurpose. Biliary organic anion excretion is mediated by an ATP-dependent primary active transporter, a so-called… 
Highly Cited
2001
Highly Cited
2001
Identification of the Apical Membrane-targeting Signal of the Multidrug Resistance-associated Protein 2 (MRP2/cMOAT)*
The human canalicular multispecific organic anion transporter (cMOAT), known as the multidrug resistance-associated protein 2… 
Review
1999
Review
1999
[Mechanisms for resistance to anticancer agents and the reversal of the resistance].
MDR results from overexpression of P-glycoprotein (Pgp) and multidrug resistance protein (MRP or MRP1) that function as ATP… 
1998
1998
Expression of γ-gluta-mylcysteine synthetase (γ-GCS) and multidrug resistance-associated protein (MRP), but not human canalicular multispecific organic anion transporter (cMOAT), genes correlates…
Highly Cited
1997
Highly Cited
1997
Human canalicular multispecific organic anion transporter (cMOAT) is expressed in human lung, gastric, and colorectal cancer cells.
Human canalicular multispecific organic anion transporter (cMOAT), a glutathione conjugate membrane transporter, has been… 
1997
1997
Differences in hepatic processing of dietary and intravenously administered copper in rats
The biliary pathway represents the major excretory route for copper (Cu). It has been suggested that glutathione (GSH) plays a… 
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