7-hydroxywarfarin

Known as: 2H-1-Benzopyran-2-one, 4,7-dihydroxy-3-(3-oxo-1-phenylbutyl)- 
 
National Institutes of Health

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2014
2014
The enantioseparation of warfarin and its main metabolite has been achieved using several cyclodextrin types and buffers at… (More)
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2011
2011
Warfarin is administered clinically as a racemic mixture of two enantiomers, (R)-warfarin and (S)-warfarin. (S)-Warfarin has more… (More)
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2010
2010
Coumadin (R/S-warfarin) anticoagulant therapy poses a risk to over 50 million Americans, in part due to interpersonal variation… (More)
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2010
2010
Clinically used anticoagulant warfarin is usually available as a racemic mixture of S- and R-warfarin that are both metabolized… (More)
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2008
2008
Chimeric mice having humanized livers were constructed by transplantation of human hepatocytes. In this study, we investigated… (More)
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Review
1997
Review
1997
The anticoagulant drug warfarin occurs as a pair of enantiomers that are differentially metabolized by human cytochromes P450… (More)
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Highly Cited
1997
Highly Cited
1997
Cytochrome P4502C9 (CYP2C9) is largely responsible for terminating the anticoagulant effect of racemic warfarin via hydroxylation… (More)
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1997
1997
Enantiomers of warfarin and 7-hydroxywarfarin in human plasma and urine, respectively, were determined by high-performance liquid… (More)
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1995
1995
The formation of 7-hydroxywarfarin in incubations of (S)-warfarin with human liver microsomes reflects their cytochrome P-4502C9… (More)
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1974
1974
An examination of the metabolic fate of the R and the S isomers of warfarin revealed that the two isomers were metabolized by… (More)
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