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7-hydroxywarfarin

Known as: 2H-1-Benzopyran-2-one, 4,7-dihydroxy-3-(3-oxo-1-phenylbutyl)- 
 
National Institutes of Health

Papers overview

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Highly Cited
2010
Highly Cited
2010
Clinically used anticoagulant warfarin is usually available as a racemic mixture of S- and R-warfarin that are both metabolized… Expand
2010
2010
Coumadin (R/S-warfarin) anticoagulant therapy poses a risk to over 50 million Americans, in part due to interpersonal variation… Expand
2008
2008
Chimeric mice having humanized livers were constructed by transplantation of human hepatocytes. In this study, we investigated… Expand
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1999
1999
To clarify the mechanism(s) for the interaction between warfarin and benzbromarone, a uricosuric agent, and to predict changes in… Expand
Review
1997
Review
1997
The anticoagulant drug warfarin occurs as a pair of enantiomers that are differentially metabolized by human cytochromes P450… Expand
Highly Cited
1997
Highly Cited
1997
Cytochrome P4502C9 (CYP2C9) is largely responsible for terminating the anticoagulant effect of racemic warfarin via hydroxylation… Expand
Highly Cited
1997
Highly Cited
1997
Enantiomers of warfarin and 7-hydroxywarfarin in human plasma and urine, respectively, were determined by high-performance liquid… Expand
1995
1995
  • D. Lang, R. Boecker
  • Journal of chromatography. B, Biomedical…
  • 1995
  • Corpus ID: 33779550
The formation of 7-hydroxywarfarin in incubations of (S)-warfarin with human liver microsomes reflects their cytochrome P-4502C9… Expand
1994
1994
To determine whether the activity of cytochrome P450 isoforms involved in the metabolism of (R) ‐warfarin is enhanced in cystic… Expand
Highly Cited
1974
Highly Cited
1974
An examination of the metabolic fate of the R and the S isomers of warfarin revealed that the two isomers were metabolized by… Expand
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