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Development of microextraction by packed sorbent for toxicological analysis of tricyclic antidepressant drugs in human oral fluid.
The aim of this study was to apply microextraction by packed sorbent (MEPS) to the isolation of six tricyclic antidepressants (TCADs): nordoxepin, doxepin, desipramine, nortriptyline, imipramine, andExpand
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Determination of acid dissociation constant of 20 coumarin derivatives by capillary electrophoresis using the amine capillary and two different methodologies.
In this work capillary electrophoresis has been used to determine acid dissociation constant of 20 structurally diverse coumarin derivatives. For a majority of compounds pKa value has been determinedExpand
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Simulation of drug metabolism
Searching for more efficient, more economical methods for simulation of drug metabolism using in-vitro methodology is one of the most rapidly developing research areas in analytical chemistry. Due toExpand
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Development of the MAE/UHPLC-MS-TOF method for determination of benzodiazepines in human bio-fluids for toxicological analysis.
A rapid method of microwave-assisted extraction (MAE) followed by ultrahigh performance liquid chromatography with mass spectrometry with time of flight detection (UHPLC-MS-TOF) was optimized andExpand
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Application of laser induced breakdown spectroscopy to examination of writing inks for forensic purposes.
The research was focused on the analysis of writing inks using the laser induced breakdown spectroscopy (LIBS) technique. 34 samples of blue, 30 of black, and 21 of red writing inks were analyzedExpand
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Tyrosinase biosensor for benzoic acid inhibition-based determination with the use of a flow-batch monosegmented sequential injection system.
Amperometric tyrosinase based biosensor for benzoic acid determination with the use of a flow-batch monosegmented sequential injection system is proposed. The functioning of the biosensor is based onExpand
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Modulation of pKa by cyclodextrins; subtle structural changes induce spectacularly different behaviors
Tuning of acidity-related properties by host–guest complexation is one of the most promising concepts in current supramolecular chemistry. However, still little is known about structural effectsExpand
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Microwave-assisted extraction of tricyclic antidepressants from human serum followed by high performance liquid chromatography determination.
A microwave-assisted extraction (MAE) method has been developed and optimized for the extraction of six tricyclic antidepressants (TCAD; nordoxepin, nortriptyline, imipramine, amitriptyline, doxepin,Expand
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Application of capillary electrophoresis in determination of acid dissociation constant values.
The chemical groups undergoing protonation or deprotonation in solution are described by the acid dissociation constant value, the key parameter for physicochemical characterization of biologically-Expand
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n-3 Fatty acids as resolvents of inflammation in the A549 cells.
BACKGROUND Fatty acids and their derivatives are one of the most crucial inflammation mediators. The aim of our study was to evaluate the impact of polyunsaturated fatty acids as eicosanoidsExpand
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