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Nitric oxide generation from nitroprusside by vascular tissue. Evidence that reduction of the nitroprusside anion and cyanide loss are required.
Propofol: The Challenges of Formulation
Propofol is a potent lipophilic anesthetic that was initially formulated in Cremophor El for human use but was ultimately brought to market as 1% propofol formulated in 10% soybean oil emulsion due to concerns of hyperlipidemia-related side effects.
Sulfite Supported Lipid Peroxidation in Propofol Emulsions
Results show that sulfite supports the peroxidation of lipids in soybean oil emulsions and propofol functions to partially inhibit these processes.
Inhibition of Volatile Sevoflurane Degradation Product Formation in an Anesthesia Circuit by a Reduction in Soda Lime Temperature
A reduction of the temperature of soda lime may be a feasible method of preventing the release of significant levels of sevoflurane degradation products without interfering with carbon dioxide absorption or altering the sev ofluranes concentration.
Inhibitory Effects of Propofol on Cytochrome P450 Activities in Rat Hepatic Microsomes
It is demonstrated that propofol does not effectively inhibit enflurane metabolism performed by the isoniazid-inducible cytochrome P450IIE1 but effectively impairs activities of the phenobarbital-ind sucrose P450 isozymes.
Pharmacological effects of intravenous melatonin: comparative studies with thiopental and propofol.
Melatonin can exert hypnotic effects similar to those observed with thiopental and propofol, and exhibited significant antinociceptive effects but was less effective in abolishing the response to tail clamping.
Metabolism-dependent binding of the chlorinated insecticide DDT and its metabolite, DDD, to microsomal protein and lipids.
Sevoflurane: are there differences in products?
- M. T. Baker
- BiologyAnesthesia and analgesia
- 1 June 2007
The manufacturing processes and impurities, sevoflurane degradation resulting from Lewis acid reactions, and suitability of nonglass containers for sev ofluranes are discussed.
Isoflurane-chlorodifluoroethene interaction in human liver microsomes. Role of cytochrome P4502B6 in potentiation of haloethene metabolism.
- M. T. Baker, M. J. Olson, Y. Wang, W. Ronnenberg, J. T. Johnson, A. N. Brady
- Biology, ChemistryDrug metabolism and disposition: the biological…
The effect of isoflurane on CDE defluorination in liver microsomes from 10 human organ donors to determine whether saturated halocarbon/haloethene interactions also occur in humans and, if so, to determine the cytochromes P450 involved.
The Effects of Plasma and Brain Magnesium Concentrations on Lidocaine-Induced Seizures in the Rat
- Y. J. Kim, C. Mcfarlane, D. Warner, M. T. Baker, W. W. Choi, F. Dexter
- Biology, MedicineAnesthesia and analgesia
- 1 December 1996
Although intracerebroventricular administration of MgSO4 produces an anticonvulsant effect, chronic hypermagnesemia does not alter whole brain [Mg2+] and therefore offers no protection from lidocaine-induced seizures in this model.