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7-Alkoxycoumarin O-Dealkylase

Known as: O-Deethylase, 7-Ethoxycoumarin, 7 Ethoxycoumarin Dealkylase, Ethoxycoumarin O Deethylase 
A drug-metabolizing enzyme found in the hepatic, placental and intestinal microsomes that metabolizes 7-alkoxycoumarin to 7-hydroxycoumarin. The… 
National Institutes of Health

Related topics

Related topics

8 relations
In BloodProcess of secretionantagonists & inhibitorsaspects of radiation effects

Narrower (1)

cytochrome P-450 CYP76B1 (Helianthus tuberosus)

Papers overview

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Highly Cited
2004
Highly Cited
2004
Effects of polybrominated diphenyl ethers on basal and TCDD-induced ethoxyresorufin activity and cytochrome P450-1A1 expression in MCF-7, HepG2, and H4IIE cells.
Polybrominated diphenylethers (PBDEs) are used as additive flame-retardants in consumer products to reduce the chances of… 
Highly Cited
1999
Highly Cited
1999
In vitro vitellogenin production by carp (Cyprinus carpio) hepatocytes as a screening method for determining (anti)estrogenic activity of xenobiotics.
The yolk protein precursor vitellogenin (Vtg) is secreted by the liver of female as well as male fish, in response to estrogenic… 
Highly Cited
1987
Highly Cited
1987
Specificity and cross-reactivity of monoclonal and polyclonal antibodies against cytochrome P-450E of the marine fish scup.
Highly Cited
1987
Highly Cited
1987
Aroclor 1254 as a 2,3,7,8-tetrachlorodibenzo-p-dioxin antagonist: effects on enzyme induction and immunotoxicity.
Highly Cited
1984
Highly Cited
1984
Monoclonal antibodies to phenobarbital-induced rat liver cytochrome P-450.
Highly Cited
1983
Highly Cited
1983
Biotransformation of coumarin derivatives. (2). Oxidative metabolism of 7-alkoxycoumarin by microsomal enzymes and a simple assay procedure for 7-alkoxycoumarin O-dealkylase.
The in vitro biotransformation of 7-alkoxycoumarin by rat liver microsomes was studied to develop a simple and accurate assay… 
Highly Cited
1982
Highly Cited
1982
Phenotyping of cytochromes P-450 in human tissues with monoclonal antibodies.
Cytochrome P-450 (P-450)-dependent aryl hydrocarbon hydroxylase (AHHase) and 7-ethoxycoumarin deethylase (ECDEtase) in human… 
1982
1982
Biotransformation of coumarin derivatives (1). 7-alkoxycoumarin O-dealkylase in liver microsomes.
The in vitro metabolic fate of 7-alkoxycoumarin was studied using liver microsomes. Microsomal enzyme catalyzed dealkylation of 7… 
Highly Cited
1982
Highly Cited
1982
Influence of estradiol and testosterone on cytochrome P-450 and monooxygenase activity in immature brook trout, Salvelinus fontinalis.
Highly Cited
1979
Highly Cited
1979
Induction and characterization of hemoprotein(s) P-450 and monooxygenation in rainbow trout (Salmo gairdneri).
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