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7-Alkoxycoumarin O-Dealkylase
Known as:
O-Deethylase, 7-Ethoxycoumarin
, 7 Ethoxycoumarin Dealkylase
, Ethoxycoumarin O Deethylase
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A drug-metabolizing enzyme found in the hepatic, placental and intestinal microsomes that metabolizes 7-alkoxycoumarin to 7-hydroxycoumarin. The…
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National Institutes of Health
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Related topics
Related topics
8 relations
In Blood
Process of secretion
antagonists & inhibitors
aspects of radiation effects
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Narrower (1)
cytochrome P-450 CYP76B1 (Helianthus tuberosus)
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2004
Highly Cited
2004
Effects of polybrominated diphenyl ethers on basal and TCDD-induced ethoxyresorufin activity and cytochrome P450-1A1 expression in MCF-7, HepG2, and H4IIE cells.
A. K. Peters
,
K. Londen
,
+4 authors
J. Sanderson
Toxicological Sciences
2004
Corpus ID: 33377836
Polybrominated diphenylethers (PBDEs) are used as additive flame-retardants in consumer products to reduce the chances of…
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Highly Cited
1999
Highly Cited
1999
In vitro vitellogenin production by carp (Cyprinus carpio) hepatocytes as a screening method for determining (anti)estrogenic activity of xenobiotics.
J. Smeets
,
T. R. Rankouhi
,
+4 authors
M. van den Berg
Toxicology and Applied Pharmacology
1999
Corpus ID: 39158705
The yolk protein precursor vitellogenin (Vtg) is secreted by the liver of female as well as male fish, in response to estrogenic…
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Highly Cited
1987
Highly Cited
1987
Specificity and cross-reactivity of monoclonal and polyclonal antibodies against cytochrome P-450E of the marine fish scup.
P. Kloepper-Sams
,
S. S. Park
,
H. Gelboin
,
J. Stegeman
Archives of Biochemistry and Biophysics
1987
Corpus ID: 57991
Highly Cited
1987
Highly Cited
1987
Aroclor 1254 as a 2,3,7,8-tetrachlorodibenzo-p-dioxin antagonist: effects on enzyme induction and immunotoxicity.
R. Bannister
,
D. Davis
,
T. Zacharewski
,
I. Tizard
,
S. Safe
Toxicology
1987
Corpus ID: 4924134
Highly Cited
1984
Highly Cited
1984
Monoclonal antibodies to phenobarbital-induced rat liver cytochrome P-450.
S. S. Park
,
T. Fujino
,
H. Miller
,
F. Guengerich
,
H. Gelboin
Biochemical Pharmacology
1984
Corpus ID: 21924435
Highly Cited
1983
Highly Cited
1983
Biotransformation of coumarin derivatives. (2). Oxidative metabolism of 7-alkoxycoumarin by microsomal enzymes and a simple assay procedure for 7-alkoxycoumarin O-dealkylase.
T. Matsubara
,
S. Otsubo
,
E. Yoshihara
,
A. Touchi
Japanese Journal of Pharmacology
1983
Corpus ID: 14036714
The in vitro biotransformation of 7-alkoxycoumarin by rat liver microsomes was studied to develop a simple and accurate assay…
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Highly Cited
1982
Highly Cited
1982
Phenotyping of cytochromes P-450 in human tissues with monoclonal antibodies.
T. Fujino
,
S. S. Park
,
D. West
,
H. Gelboin
Proceedings of the National Academy of Sciences…
1982
Corpus ID: 32649451
Cytochrome P-450 (P-450)-dependent aryl hydrocarbon hydroxylase (AHHase) and 7-ethoxycoumarin deethylase (ECDEtase) in human…
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1982
1982
Biotransformation of coumarin derivatives (1). 7-alkoxycoumarin O-dealkylase in liver microsomes.
T. Matsubara
,
E. Yoshihara
,
T. Iwata
,
Y. Tochino
,
Y. Hachino
Japanese Journal of Pharmacology
1982
Corpus ID: 5985698
The in vitro metabolic fate of 7-alkoxycoumarin was studied using liver microsomes. Microsomal enzyme catalyzed dealkylation of 7…
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Highly Cited
1982
Highly Cited
1982
Influence of estradiol and testosterone on cytochrome P-450 and monooxygenase activity in immature brook trout, Salvelinus fontinalis.
J. Stegeman
,
A. Pajor
,
Peter Thomas
Biochemical Pharmacology
1982
Corpus ID: 25905244
Highly Cited
1979
Highly Cited
1979
Induction and characterization of hemoprotein(s) P-450 and monooxygenation in rainbow trout (Salmo gairdneri).
C. Elcombe
,
J. Lech
Toxicology and Applied Pharmacology
1979
Corpus ID: 41627153
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