7-Alkoxycoumarin O-Dealkylase

Known as: O-Deethylase, 7-Ethoxycoumarin, 7 Ethoxycoumarin Dealkylase, Ethoxycoumarin O Deethylase 
A drug-metabolizing enzyme found in the hepatic, placental and intestinal microsomes that metabolizes 7-alkoxycoumarin to 7-hydroxycoumarin. The… (More)
National Institutes of Health

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cytochrome P-450 CYP76B1 (Helianthus tuberosus)

Papers overview

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Highly Cited
2005
Highly Cited
2005
Copper-induced oxidative stress in three-spined stickleback: relationship with hepatic metal levels.
The aim of this study was to characterise biomarker responses in three-spined sticklebacks exposed to copper. For this purpose… (More)
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Highly Cited
2004
Highly Cited
2004
Validated assays for human cytochrome P450 activities.
The measurement of the effect of new chemical entities on human cytochrome P450 marker activities using in vitro experimentation… (More)
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Highly Cited
2004
Highly Cited
2004
Assessment of DE-71, a commercial polybrominated diphenyl ether (PBDE) mixture, in the EDSP male and female pubertal protocols.
DE-71, a commercial mixture, was used to test the sensitivity of the female and male pubertal protocol to detect thyroid active… (More)
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Highly Cited
2002
Highly Cited
2002
Developmental exposure to brominated diphenyl ethers results in thyroid hormone disruption.
The objective of the current study was to characterize the effects of DE-71 (a commercial polybrominated diphenyl ether mixture… (More)
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Highly Cited
2002
Highly Cited
2002
Biotransformation, genotoxic, and histopathological effects of environmental contaminants in European eel (Anguilla anguilla L.).
A prolonged toxicity study was carried out in young European eel (Anguilla anguilla L.) to evaluate the effects of environmental… (More)
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Highly Cited
2001
Highly Cited
2001
Effects of short-term in vivo exposure to polybrominated diphenyl ethers on thyroid hormones and hepatic enzyme activities in weanling rats.
Polybrominated diphenyl ethers (PBDEs), used as flame retardants, are ubiquitous environmental contaminants. PBDEs act as… (More)
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Highly Cited
1993
Highly Cited
1993
Cytokines down-regulate expression of major cytochrome P-450 enzymes in adult human hepatocytes in primary culture.
Cytokines are thought to cause the depression of cytochrome P-450 (CYP)-associated drug metabolism in humans during inflammation… (More)
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1989
1989
Comparison of the effects of various inducers on 7-alkoxycoumarin O-dealkylase activities in liver microsomes.
The effects of six inducers and malotilate on 7-alkoxycoumarin O-dealkylase activities in rat liver microsomes were examined… (More)
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1983
1983
Biotransformation of coumarin derivatives. (2). Oxidative metabolism of 7-alkoxycoumarin by microsomal enzymes and a simple assay procedure for 7-alkoxycoumarin O-dealkylase.
The in vitro biotransformation of 7-alkoxycoumarin by rat liver microsomes was studied to develop a simple and accurate assay… (More)
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1982
1982
Biotransformation of coumarin derivatives (1). 7-alkoxycoumarin O-dealkylase in liver microsomes.
The in vitro metabolic fate of 7-alkoxycoumarin was studied using liver microsomes. Microsomal enzyme catalyzed dealkylation of 7… (More)
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