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7-Alkoxycoumarin O-Dealkylase

Known as: O-Deethylase, 7-Ethoxycoumarin, 7 Ethoxycoumarin Dealkylase, Ethoxycoumarin O Deethylase 
A drug-metabolizing enzyme found in the hepatic, placental and intestinal microsomes that metabolizes 7-alkoxycoumarin to 7-hydroxycoumarin. The… Expand
National Institutes of Health

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In BloodProcess of secretionantagonists & inhibitorsaspects of radiation effects
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cytochrome P-450 CYP76B1 (Helianthus tuberosus)

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Highly Cited
2009
Highly Cited
2009
Acute effects of copper and mercury on the estuarine fish Pomatoschistus microps: linking biomarkers to behaviour.
The main objective of the present study was to investigate possible links between biomarkers and swimming performance in the… Expand
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Highly Cited
2004
Highly Cited
2004
Validated assays for human cytochrome P450 activities.
  • R. Walsky, R. Obach
  • Drug metabolism and disposition: the biological…
  • 2004
    • Corpus ID: 8789343
The measurement of the effect of new chemical entities on human cytochrome P450 marker activities using in vitro experimentation… Expand
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Highly Cited
2004
Highly Cited
2004
Assessment of DE-71, a commercial polybrominated diphenyl ether (PBDE) mixture, in the EDSP male and female pubertal protocols.
DE-71, a commercial mixture, was used to test the sensitivity of the female and male pubertal protocol to detect thyroid active… Expand
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Highly Cited
2002
Highly Cited
2002
Developmental exposure to brominated diphenyl ethers results in thyroid hormone disruption.
The objective of the current study was to characterize the effects of DE-71 (a commercial polybrominated diphenyl ether mixture… Expand
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Highly Cited
2002
Highly Cited
2002
Biotransformation, genotoxic, and histopathological effects of environmental contaminants in European eel (Anguilla anguilla L.).
A prolonged toxicity study was carried out in young European eel (Anguilla anguilla L.) to evaluate the effects of environmental… Expand
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Highly Cited
2001
Highly Cited
2001
Effects of short-term in vivo exposure to polybrominated diphenyl ethers on thyroid hormones and hepatic enzyme activities in weanling rats.
Polybrominated diphenyl ethers (PBDEs), used as flame retardants, are ubiquitous environmental contaminants. PBDEs act as… Expand
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Highly Cited
2000
Highly Cited
2000
PAH metabolites in bile, cytochrome P4501A and DNA adducts as environmental risk parameters for chronic oil exposure: a laboratory experiment with Atlantic cod.
In order to perform environmental risk assessments with regard to oil contamination in the sea, it is important to obtain… Expand
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Highly Cited
1997
Highly Cited
1997
Aryl hydrocarbon receptor-dependent induction of cyp1a1 by bilirubin in mouse hepatoma hepa 1c1c7 cells.
Heme metabolism normally involves enzymatic conversion to biliverdin and subsequently to bilirubin, catalyzed by heme oxygenase… Expand
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Highly Cited
1993
Highly Cited
1993
Cytokines down-regulate expression of major cytochrome P-450 enzymes in adult human hepatocytes in primary culture.
Cytokines are thought to cause the depression of cytochrome P-450 (CYP)-associated drug metabolism in humans during inflammation… Expand
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Highly Cited
1978
Highly Cited
1978
An improved assay of 7-ethoxycoumarin O-deethylase activity: induction of hepatic enzyme activity in C57BL/6J and DBA/2J mice by phenobarbital, 3-methylcholanthrene and 2,3,7,8-tetrachlorodibenzo-p…
An improved in vitro fluorometric assay of the O-deethylation of 7-ethoxycoumarin which is at least 10 times more sensitive than… Expand
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