• Publications
  • Influence
Molecular properties of the SLC13 family of dicarboxylate and sulfate transporters
  • A. Pajor
  • Biology
    Pflügers Archiv
  • 1 February 2006
TLDR
An update is provided on new advances in this gene family, particularly on structure–function studies and new members of the SLC13 superfamily that exhibit both sodium-dependent and sodium-independent transport mechanisms.
Sodium-coupled dicarboxylate and citrate transporters from the SLC13 family
  • A. Pajor
  • Biology
    Pflügers Archiv - European Journal of Physiology
  • 2013
TLDR
This review summarizes current knowledge of the structure, function, and regulation of the di- and tricarboxylate transporters of the SLC13 family and provides a new framework for understanding the mechanism of transport in this family.
Cloning of a human kidney cDNA with similarity to the sodium-glucose cotransporter.
TLDR
Low-stringency screening with the human intestinal Na(+)-glucose cotransporter S GLT1 is used to isolate a 2,271-nucleotide cDNA (Hu14) from human kidney, which is 59% identical at the amino acid level to SGLT1 and has a similar number and arrangement of predicted membrane-spanning regions.
Primary Structure and Functional Characteristics of a Mammalian Sodium-coupled High Affinity Dicarboxylate Transporter*
TLDR
Data show that NaDC3 interacts preferentially with the divalent anionic species of citrate, and this represents the first report on the cloning and functional characterization of a mammalian Na+-dependent, high affinity dicarboxylate transporter.
Molecular cloning and functional expression of a sodium-dicarboxylate cotransporter from human kidney.
  • A. Pajor
  • Biology
    The American journal of physiology
  • 1 April 1996
TLDR
This study provides the first demonstration that the human kidney contains a low-affinity Na(+)-dicarboxylate cotransporter with properties that resemble those of the Na( +)-dICarboxyate cOTransporter on the apical membrane of the rabbit renal proximal tubule.
Protein kinase C-mediated regulation of the renal Na(+)/dicarboxylate cotransporter, NaDC-1.
  • A. Pajor, N. Sun
  • Biology, Computer Science
    Biochimica et biophysica acta
  • 20 August 1999
Sequence and Functional Characterization of a Renal Sodium/Dicarboxylate Cotransporter (*)
  • A. Pajor
  • Biology
    The Journal of Biological Chemistry
  • 17 March 1995
TLDR
The results of the functional characterization indicate that NaDC-1 likely corresponds to the renal brush-border Na/dicarboxylate cotransporter, which carries citrate and may be found in liver, lung, and adrenal.
Inhibitor Binding in the Human Renal Low- and High-Affinity Na+/Glucose Cotransporters
TLDR
Differences in the effects of the mutations between hS GLT1 and hSGLT2 suggest that this cysteine holds key residues in place rather than participating directly in inhibitor binding in the human transporters.
Molecular Properties of Sodium/Dicarboxylate Cotransporters
  • A. Pajor
  • Biology
    The Journal of Membrane Biology
  • 1 May 2000
TLDR
The purpose of this review is to provide an update on new advances, particularly in the cloning and characterization of members of the NaDC/NaSi gene family, with functional characteristics similar to those previously identified in isolated organs or membrane vesicles.
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