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Molecular properties of the SLC13 family of dicarboxylate and sulfate transporters
  • A. Pajor
  • Medicine, Chemistry
  • Pflügers Archiv
  • 1 February 2006
The SLC13 gene family consists of five members in humans, with corresponding orthologs from different vertebrate species. All five genes code for sodium-coupled transporters that are found on theExpand
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Sodium-coupled dicarboxylate and citrate transporters from the SLC13 family
  • A. Pajor
  • Biology, Medicine
  • Pflügers Archiv - European Journal of Physiology
  • 2013
The SLC13 family in humans and other mammals consists of sodium-coupled transporters for anionic substrates: three transporters for dicarboxylates/citrate and two transporters for sulfate. ThisExpand
  • 76
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Protein kinase C-mediated regulation of the renal Na(+)/dicarboxylate cotransporter, NaDC-1.
  • A. Pajor, N. Sun
  • Chemistry, Medicine
  • Biochimica et biophysica acta
  • 20 August 1999
The Na(+)/dicarboxylate cotransporter of the renal proximal tubule, NaDC-1, reabsorbs Krebs cycle intermediates, such as succinate and citrate, from the tubular filtrate. Although long-termExpand
  • 35
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Cloning of a human kidney cDNA with similarity to the sodium-glucose cotransporter.
We have used low-stringency screening with the human intestinal Na(+)-glucose cotransporter SGLT1 to isolate a 2,271-nucleotide cDNA (Hu14) from human kidney. This clone, which encodes a 672-residueExpand
  • 152
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Primary Structure and Functional Characteristics of a Mammalian Sodium-coupled High Affinity Dicarboxylate Transporter*
We have cloned a Na+-dependent, high affinity dicarboxylate transporter (NaDC3) from rat placenta. NaDC3 exhibits 48% identity in amino acid sequence with rat NaDC1, a Na+-dependent, low affinityExpand
  • 96
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Molecular cloning and functional expression of a sodium-dicarboxylate cotransporter from human kidney.
  • A. Pajor
  • Chemistry, Medicine
  • The American journal of physiology
  • 1 April 1996
The renal Na(+)-dicarboxylate cotransporter reabsorbs Krebs cycle intermediates, such as succinate and citrate, from the glomerular filtrate. The present study describes the cloning andExpand
  • 70
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Inhibitor Binding in the Human Renal Low- and High-Affinity Na+/Glucose Cotransporters
The kidney contains two Na+/glucose cotransporters, called SGLT2 and SGLT1, arranged in series along the length of the proximal tubule. The low-affinity transporter, SGLT2, is responsible for theExpand
  • 55
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Sequence and Functional Characterization of a Renal Sodium/Dicarboxylate Cotransporter (*)
  • A. Pajor
  • Chemistry, Medicine
  • The Journal of Biological Chemistry
  • 17 March 1995
The cDNA coding for a rabbit renal Na/dicarboxylate cotransporter, designated NaDC-1, was isolated by functional expression in Xenopus oocytes. NaDC-1 cDNA is approximately 2.3 kilobases in lengthExpand
  • 135
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Molecular Properties of Sodium/Dicarboxylate Cotransporters
  • A. Pajor
  • Medicine, Chemistry
  • The Journal of Membrane Biology
  • 1 May 2000
The active transport of Krebs cycle intermediates, such as succinate, a-ketoglutarate and citrate, is mediated by sodium-coupled transporters found on the plasma membranes of many epithelial cells.Expand
  • 65
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Chronic metabolic acidosis increases NaDC-1 mRNA and protein abundance in rat kidney.
BACKGROUND Chronic metabolic acidosis increases, while alkali feeding inhibits, proximal tubule citrate absorption. The activity of the apical membrane Na+/citrate cotransporter is increased inExpand
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