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Toxic equivalency factors (TEFs) for PCBs, PCDDs, PCDFs for humans and wildlife.
TLDR
It was concluded that the TEF concept is still the most plausible and feasible approach for risk assessment of halogenated aromatic hydrocarbons with dioxinlike properties.
Purification, cloning, and RXR identity of the HeLa cell factor with which RAR or TR heterodimerizes to bind target sequences efficiently.
TLDR
It is shown that unstable RAR-RXR heterodimers were formed in solution, and that C-terminal sequences and the DNA-binding domains of both receptors were required for efficient formation of stable heterodIMers on response elements.
Differential estrogen receptor binding of estrogenic substances: a species comparison
Comparative toxicogenomic analysis of the hepatotoxic effects of TCDD in Sprague Dawley rats and C57BL/6 mice.
TLDR
Understanding of TCDD-mediated gene expression responses is expanded and indicates that species-specific toxicity may be mediated by differences in gene expression which may help explain the wide range of species sensitivities and will have important implications in risk assessment strategies.
Evidence of Estrogen- and TCDD-Like Activities in Crude and Fractionated Extracts of PM10 Air Particulate Material Using in Vitro Gene Expression Assays
TLDR
Results from the analyses of nine environmentally prevalent polyaromatic hydrocarbons (PAH) indicated that PAH might be significant contributors to the observed activity.
In Vitro and in Vivo Interactions of Bisphenol A and Its Metabolite, Bisphenol A Glucuronide, with Estrogen Receptors α and β
TLDR
Results demonstrate that BPA competes more effectively for binding to ERbeta, but induces ERalpha- and ERbeta-mediated gene expression with comparable efficacy, while BPA-G did not exhibit any in vitro estrogenic activity.
In Vitro Bioassays for Assessing Estrogenic Substances
This past summer, United States President Bill Clinton signed into law amendments to the Safe Drinking Water Act and Food Quality Protection Act that include clauses requiring the EPA to develop te...
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