• Publications
  • Influence
The 2005 World Health Organization reevaluation of human and Mammalian toxic equivalency factors for dioxins and dioxin-like compounds.
TLDR
Concern was expressed about direct application of the TEF/total toxic equivalency (TEQ) approach to abiotic matrices, such as soil, sediment, etc., for direct application in human risk assessment as the present TEF scheme and TEQ methodology are primarily intended for estimating exposure and risks via oral ingestion. Expand
Toxic equivalency factors (TEFs) for PCBs, PCDDs, PCDFs for humans and wildlife.
TLDR
It was concluded that the TEF concept is still the most plausible and feasible approach for risk assessment of halogenated aromatic hydrocarbons with dioxinlike properties. Expand
Interaction of Estrogenic Chemicals and Phytoestrogens with Estrogen Receptor β.
TLDR
The estrogenic activity of environmental chemicals and phytoestrogens in competition binding assays with ERα or ERβ protein, and in a transient gene expression assay using cells in which an acute estrogenic response is created by cotransfecting cultures with recombinant human ERβ complementary DNA (cDNA) in the presence of an estrogen-dependent reporter plasmid are investigated. Expand
Polychlorinated biphenyls (PCBs): environmental impact, biochemical and toxic responses, and implications for risk assessment.
  • S. Safe
  • Chemistry, Medicine
  • Critical reviews in toxicology
  • 1994
TLDR
Analysis of the results of laboratory animal and wildlife studies suggests that the predictive value of TEQs for PCBs may be both species- and response-dependent because both additive and nonadditive (antagonistic) interactions have been observed with PCB mixtures. Expand
Polychlorinated biphenyls (PCBs), dibenzo-p-dioxins (PCDDs), dibenzofurans (PCDFs), and related compounds: environmental and mechanistic considerations which support the development of toxic
  • S. Safe
  • Chemistry, Medicine
  • Critical reviews in toxicology
  • 1990
TLDR
The most toxic halogenated aromatic is 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and based on in vivo and in vitro studies the relative toxicities have been determined relative to TCDD (i.e., toxic equivalents). Expand
Re Human and Mammalian Toxic Equivalency Factors for Dioxins and Dioxin-Like Compounds: The Who 2005 Re-Evaluation
Re Human and Mammalian Toxic Equivalency Factors for Dioxins and Dioxin-Like Compounds: The Who 2005 Re-Evaluation
Structure-dependent, competitive interaction of hydroxy-polychlorobiphenyls, -dibenzo-p-dioxins and -dibenzofurans with human transthyretin.
TLDR
A profound similarity in structural requirements for TTR binding between hydroxy-PCB, -PCDD and -PCDF metabolites and the physiological ligand, T4 is found, e.g. halogen substitution adjacent to the para hydroxy group, while planarity does not seem to influence the ligand-binding potency. Expand
HOTAIR IS A NEGATIVE PROGNOSTIC FACTOR AND EXHIBITS PRO-ONCOGENIC ACTIVITY IN PANCREATIC CANCER
TLDR
HOTAIR expression is increased in pancreatic tumors compared with non-tumor tissue and is associated with more aggressive tumors, and HOTAIR uniquely suppressed several interferon-related genes and gene sets related to cell cycle progression in Pancic cancer cells and tumors. Expand
Polychlorinated biphenyls (PCBs) and polybrominated biphenyls (PBBs): biochemistry, toxicology, and mechanism of action.
  • S. Safe
  • Chemistry, Medicine
  • Critical reviews in toxicology
  • 1984
TLDR
The results clearly show that like "dioxin", the PCBs and PBBs elicit their effects through a cytosolic receptor protein which preferentially binds with the toxins which are approximate isostereomers of 2,3,7,8-TCDD. Expand
Transcriptional activation of genes by 17 beta-estradiol through estrogen receptor-Sp1 interactions.
  • S. Safe
  • Biology, Medicine
  • Vitamins and hormones
  • 2001
TLDR
Results of ongoing studies suggest that ER alpha/Sp1 plays an important role in transcriptional activation of multiple growth regulatory genes in breast cancer cells. Expand
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