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5-hydroxypropafenone

 
National Institutes of Health

Papers overview

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2003
2003
OBJECTIVES Propafenone is a class Ic antiarrhythmic drug used to maintain sinus rhythm in patients with atrial fibrillation… Expand
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1999
1999
An enantioselective liquid chromatography method was developed for the simultaneous determination of propafenone (PPF) and 5… Expand
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Highly Cited
1993
Highly Cited
1993
The activity of metabolizing enzymes determines plasma concentrations and hence effects of drugs. Identification of these enzymes… Expand
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Highly Cited
1989
Highly Cited
1989
Propafenone is a new class 1 antiarrhythmic agent. The drug is extensively metabolized. 5‐Hydroxylation and N‐dealkylation… Expand
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1988
1988
We compared the electrophysiologic, inotropic and antiarrhythmic properties of propafenone and two metabolites, 5-hydroxy (5-OH… Expand
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Highly Cited
1987
Highly Cited
1987
The relationship between debrisoquine metabolic phenotype and the pharmacokinetics and pharmacodynamics of propafenone was… Expand
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1987
1987
Summary The effects of 5-hydroxypropafenone (5-OH-P), the main metabolite of propafenone, were studied in guinea pig papillary… Expand
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1987
1987
Tissue distribution of antiarrhythmic drugs, and particularly their myocardium uptake, can be relevant in the interpretation of… Expand
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Highly Cited
1985
Highly Cited
1985
The cumulation of propafenone and two of its metabolites, 5‐hydroxypropafenone (5‐OHP) and N‐depropylpropafenone (NDPP), was… Expand
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Highly Cited
1984
Highly Cited
1984
The new antiarrhythmic drug propafenone and its main human metabolite 5-hydroxypropafenone were investigated for antiarrhythmic… Expand
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