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Propafenone is a class Ic antiarrhythmic drug used to maintain sinus rhythm in patients with atrial fibrillation… Expand An enantioselective liquid chromatography method was developed for the simultaneous determination of propafenone (PPF) and 5… Expand The activity of metabolizing enzymes determines plasma concentrations and hence effects of drugs. Identification of these enzymes… Expand Propafenone is a new class 1 antiarrhythmic agent. The drug is extensively metabolized. 5‐Hydroxylation and N‐dealkylation… Expand We compared the electrophysiologic, inotropic and antiarrhythmic properties of propafenone and two metabolites, 5-hydroxy (5-OH… Expand The relationship between debrisoquine metabolic phenotype and the pharmacokinetics and pharmacodynamics of propafenone was… Expand Summary The effects of 5-hydroxypropafenone (5-OH-P), the main metabolite of propafenone, were studied in guinea pig papillary… Expand Tissue distribution of antiarrhythmic drugs, and particularly their myocardium uptake, can be relevant in the interpretation of… Expand The cumulation of propafenone and two of its metabolites, 5‐hydroxypropafenone (5‐OHP) and N‐depropylpropafenone (NDPP), was… Expand The new antiarrhythmic drug propafenone and its main human metabolite 5-hydroxypropafenone were investigated for antiarrhythmic… Expand