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5-hydroxypropafenone

National Institutes of Health

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Broader (3)

Adrenergic beta-AntagonistsAnti-Arrhythmia AgentsPropafenone
analogs & derivatives

Papers overview

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2019
2019
A sensitive quantitative assay for the determination of propafenone and two metabolites, 5-hydroxypropafenone and N-depropylpropafenone, in human K2EDTA plasma using LC-MS/MS with ESI operated in…
2017
2017
A Sensitive and Rapid LC – MSMS Method for Simultaneous Determination of Propafenone and Its Active Metabolite 5-Hydroxypropafenone in Human Plasma and Its Application in a Pharmacokinetic Study
A simple and rapid high-performance liquid chromatography tandem mass spectrometry method for the determination of propafenone… 
2016
2016
Effect of CYP 2 D 6 polymorphisms on the pharmacokinetics of propafenone and its two main metabolites Propafenone disposition in CYP 2 D 5 polymorphism
2010
2010
The metabolic fate of2H-labelled propafenone in man
SummaryThe metabolism of propafenone was studied in three humans by using 300 mg of the deuterated compound given orally. The… 
2001
2001
Transient Outward Current Inhibition by Propafenone and 5‐Hydroxypropafenone in Cultured Neonatal Rat Ventricular Myocytes
&NA; The antiarrhythmic agent propafenone and its primary electropharmacologically active metabolite, 5‐hydroxypropafenone, are… 
1990
1990
The Relative Potency of Major Metabolites and Enantiomers of Propafenone in an Experimental Reperfusion Arrhythmia Model
We used isolated rat hearts subjected to coronary artery ligation and reperfusion to study the antiarhythmic activity of 5… 
1990
1990
Protein binding displacement interactions between propafenone, 5-hydroxypropafenone and other antiarrhythmic drugs, HPLC analysis of indocyanine green
1990
1990
The in vitro characterization of the drug-protein binding of racemic propafenone, and its active metabolite 5-hydroxypropafenone in human serum, and in solutions of isolated human serum proteins
1984
1984
Simultaneous determination of propafenone and 5-hydroxypropafenone in plasma by means of high pressure liquid chromatography.
A high pressure liquid chromatographic (HPLC) method with internal analogue standardization for the simultaneous determination of…