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Pharmacology of cardiac potassium channels.
Functional Effects of KCNE3 Mutation and Its Role in the Development of Brugada Syndrome
- E. Delpón, J. Cordeiro, C. Antzelevitch
- Biology, MedicineCirculation. Arrhythmia and electrophysiology
- 1 August 2008
These results provide definitive evidence for a functional role of KCNE3 in the modulation of Ito in the human heart and suggest that mutations in KC NE3 can underlie the development of the Brugada syndrome.
PITX2 Insufficiency Leads to Atrial Electrical and Structural Remodeling Linked to Arrhythmogenesis
PITX2 is identified as an upstream transcriptional regulator of atrial electric function, the insufficiency of which results in cellular and molecular changes leading to atrialElectric and structural remodeling linked to arrhythmogenesis.
Cardiac electrophysiological effects of nitric oxide.
- J. Tamargo, R. Caballero, R. Gómez, E. Delpón
- Biology, MedicineCardiovascular research
- 1 September 2010
The role of NO in the genesis of cardiac arrhythmias during ischemia-reperfusion, heart failure, long QT syndrome, atrial fibrillation, and sudden cardiac death is reviewed.
Mutations in the cardiac L-type calcium channel associated with inherited J-wave syndromes and sudden cardiac death.
Pitx2c increases in atrial myocytes from chronic atrial fibrillation patients enhancing IKs and decreasing ICa,L.
The results demonstrated for the first time that CAF increases Pitx2c expression in isolated human atrial myocytes and suggested that this transcription factor could contribute to the CAF-induced IKs increase and ICa,L reduction observed in humans.
Stereoselective block of a human cardiac potassium channel (Kv1.5) by bupivacaine enantiomers.
In humans, chronic atrial fibrillation decreases the transient outward current and ultrarapid component of the delayed rectifier current differentially on each atria and increases the slow component…
Molecular determinants of stereoselective bupivacaine block of hKv1.5 channels.
The results suggest that (1) the bupivacaine binding site is located in the inner mouth of the pore, (2) stereoselective block displays subfamily selectivity, and (3) a polar interaction with T505 combined with hydrophobic interactions with L508 and V512 are required for stereoselectedive block.