G. Mckay

Publications137
h-index26
Citations4,191
Highly Influential Citations154
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Bioanalytical Method Validation—A Revisit with a Decade of Progress
TLDR
The purpose of this report is to represent the progress in analytical methodologies over the last decade and assessment of the major agreements and issues discussed with regard to small molecules at both the conference and the workshop.
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Effects of scopolamine on delayed-matching-to-sample and paired associates tests of visual memory and learning in human subjects: comparison with diazepam and implications for dementia
TLDR
It is suggested that scopolamine can produce selective deficits in tests of short-term visual recognition memory which do not depend on overall impairments in arousal and which contrast with deficits in visual associative learning produced by diazepam.
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In vitro characterization of the metabolism of haloperidol using recombinant cytochrome p450 enzymes and human liver microsomes.
TLDR
Interestingly, it was found that recombinant CYP1A1 has the highest activity for oxidizing RHP(+) to HP(+), which suggests a prominent role for CYP3A4 in the metabolism of HAL.
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Analytical methods validation: Bioavailability, bioequivalence and pharmacokinetic studies
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Characterization of the human hepatic cytochromes P450 involved in the in vitro oxidation of clozapine.
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Bioequivalence; Its History, Practice, and Future
TLDR
There is a continuing attempt by national regulatory authorities, international public health organization, pharmaceutical, and basic scientists to understand and develop more efficient and scientifically valid approaches to assess bioequivalence of various dosage forms including some of the tough complex special dosage forms.
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N-oxygenation of clozapine by flavin-containing monooxygenase.
The involvement of FMO in the N-oxygenation of CLZ was investigated by use of purified FMOs and human liver microsomes that contained the mean amount of immunoreactive FMO3 relative to other human…
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Stability and enzymatic hydrolysis of quaternary ammonium-linked glucuronide metabolites of drugs with an aliphatic tertiary amine-implications for analysis.
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In vitro identification of the human cytochrome p450 enzymes involved in the oxidative metabolism of loxapine
TLDR
In vitro studies were conducted to identify the hepatic cytochrome P450 (CYP) enzymes responsible for the oxidative metabolism of loxapine to 8‐hydroxyloxabine, 7‐HydroxylOxapine, N‐desmethylloxapines (amoxapin) and loxAPine N‐oxide, and indicated that l oxapine was mainly metabolized by human liver microsomes.
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Combining bupropion SR with venlafaxine, paroxetine, or fluoxetine: a preliminary report on pharmacokinetic, therapeutic, and sexual dysfunction effects.
TLDR
Bupropion had an effect on the pharmacokinetics of venlafaxine but not those of the SSRIs.
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