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5' Flanking Region

Known as: Flanking Sequences, 5', Sequence, 5' Flanking, Regions, 5' Flanking 
The region of DNA which borders the 5' end of a transcription unit and where a variety of regulatory sequences are located.
National Institutes of Health

Related topics

Related topics

3 relations
5' Untranslated Regionsaspects of radiation effectsphysiological aspects

Papers overview

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Highly Cited
2006
Highly Cited
2006
Genes directly regulated by LEAFY COTYLEDON2 provide insight into the control of embryo maturation and somatic embryogenesis.
The B3 domain protein LEAFY COTYLEDON2 (LEC2) is required for several aspects of embryogenesis, including the maturation phase… 
Review
2006
Review
2006
A family affair: var genes, PfEMP1 binding, and malaria disease.
Highly Cited
1999
Highly Cited
1999
Polymorphic haplotypes of the interleukin-10 5' flanking region determine variable interleukin-10 transcription and are associated with particular phenotypes of juvenile rheumatoid arthritis.
OBJECTIVE To determine the distribution of the interleukin-10 (IL-10) 5' flanking region haplotypes in children with arthritis… 
Highly Cited
1997
Highly Cited
1997
Transposable elements as sources of variation in animals and plants.
A tremendous wealth of data is accumulating on the variety and distribution of transposable elements (TEs) in natural populations… 
Highly Cited
1997
Highly Cited
1997
Identification and characterization of polymorphisms in the promoter region of the human Apo-1/Fas (CD95) gene.
Highly Cited
1992
Highly Cited
1992
Silencing the type II sodium channel gene: A model for neural-specific gene regulation
Highly Cited
1989
Highly Cited
1989
Gene replacement in Dictyostelium: generation of myosin null mutants.
The eukaryotic slime mold Dictyostelium discoideum has a single conventional myosin heavy chain gene (mhcA). The elimination of… 
Highly Cited
1989
Highly Cited
1989
The 5′ flanking region of the pS2 gene contains a complex enhancer region responsive to oestrogens, epidermal growth factor, a tumour promoter (TPA), the c‐Ha‐ras oncoprotein and the c‐jun protein.
Expression of the pS2 gene which is transcriptionally controlled by oestrogens in the breast cancer cell line MCF‐7 is oestrogen… 
Highly Cited
1984
Highly Cited
1984
A 12-base-pair DNA motif that is repeated several times in metallothionein gene promoters confers metal regulation to a heterologous gene.
To define DNA sequences involved in mouse metallothionein-I (MT-I) gene promoter function and metal regulation, we fused the 5… 
Highly Cited
1982
Highly Cited
1982
Clusters of genes encoding mouse transplantation antigens
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