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4-Nitroquinoline-1-oxide

Known as: 4 Nitroquinoline 1 oxide, 4-NQO, 4 nitroquinoline N oxide 
A quinoline derivative with potent tumorigenic activity. 4-nitroquinoline-1-oxide (4-NQO) potentially induces DNA damage by either binding directly… 
National Institutes of Health

Related topics

Related topics

11 relations

Narrower (3)

2-methyl-4-nitroquinoline 1-oxide4-nitroquinolone-1-oxide6-nitroquinoline 1-oxide

Broader (4)

CarcinogensMutagensNitroquinoline oxideQuinolines
analogs & derivativesaspects of radiation effectschemical synthesisstandards characteristics

Papers overview

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1987
1987
H-2-controlled genetic susceptibility to pulmonary adenomas induced by urethane and 4-nitroquinoline 1-oxide in A/Wy congenic strains.
The genetic effect of the H-2 complex on the development of chemically induced pulmonary adenomas was clearly demonstrated in H-2… 
Highly Cited
1984
Highly Cited
1984
Fibroblasts from patients with hereditary cutaneous malignant melanoma are abnormally sensitive to the mutagenic effect of simulated sunlight and 4-nitroquinoline 1-oxide.
Because of a possible etiologic link between mutations and carcinogenesis, we compared fibroblasts derived from skin biopsies of… 
Highly Cited
1979
Highly Cited
1979
Interactions of the carcinogen 4-nitroquinoline 1-oxide with the non-protein thiols of mammalian cells.
The carcinogen 4-nitroquinoline 1-oxide (4-NQO) was found to rapidly deplete non-protein thiols (NPSH) from Ehrlich ascites tumor… 
1977
1977
Excision of 4-Nitroquinoline 1-Oxide Damage and Transformation in Mouse Cells
For elucidation of the role of repair mechanisms for carci nogenesis by chemical agents, cell transformation by 4nitroquinoline 1… 
1974
1974
Enhancement of Simian virus 40-induced transformation of Chinese hamster embryo cells by 4-nitroquinoline 1-oxide.
Treatment of Chinese hamster embryo cells with 4-nitroquinoline 1-oxide (4NQO) enhanced the frequency of SV40-induced… 
1974
1974
Enhancement of simian virus 40 transformation and integration by 4-nitroquinoline 1-oxide.
Treatment of Chinese hamster embryo cells with 4-nitroquinoline 1-oxide prior to infection with SV40 increases the frequency of… 
1972
1972
Sensitivity of repair-deficient mutants and similar mutants to 4-nitroquinoline 1-oxide, 4-nitropyridine 1-oxide, and their derivatives.
The chemical carcinogens, 4-nitroquinoline 1-oxide and 4-nitropyridine 1-oxide, and their carcinogenic or noncarcinogenic… 
1972
1972
Strand scission and rejoining of DNA in cultured mammalian cells induced by 4-nitroquinoline 1-oxide.
The effect of the carcinogen, 4-nitroquinoline 1-oxide, on cultured mouse fibroblasts, strain L-P3, a substrain of L-929, was… 
1968
1968
Single Strand Scissions of DNA caused by a Carcinogen, 4-Hydroxylaminoquinoline I-Oxide
4-HYDROXYLAMINOQUINOLINE I-oxide (4-HAQO) is a reductive product of a carcinogen, 4-nitroquinoline I-oxide (4-NQO), and is… 
Highly Cited
1966
Highly Cited
1966
The metabolism of 4-nitroquinoline-1-oxide, a carcinogen. 3. An enzyme catalyzing the conversion of 4-nitroquinoline-1-oxide to 4-hydroxyaminoquinoline-1-oxide in rat liver and hepatomas.
Summary The activity of an enzyme that converts 4-nitroquinoline-1-oxide, a carcinogen, to 4-hydroxyaminoquinoline-1-oxide, a… 
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