Skip to search formSkip to main contentSkip to account menu

4-Nitroquinoline-1-oxide

Known as: 4 Nitroquinoline 1 oxide, 4-NQO, 4 nitroquinoline N oxide 
A quinoline derivative with potent tumorigenic activity. 4-nitroquinoline-1-oxide (4-NQO) potentially induces DNA damage by either binding directly… 
National Institutes of Health

Related topics

Related topics

11 relations

Narrower (3)

2-methyl-4-nitroquinoline 1-oxide4-nitroquinolone-1-oxide6-nitroquinoline 1-oxide

Broader (4)

CarcinogensMutagensNitroquinoline oxideQuinolines
analogs & derivativesaspects of radiation effectschemical synthesisstandards characteristics

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2001
Highly Cited
2001
Increased expression of cyclooxygenase-2 protein in 4-nitroquinoline-1-oxide-induced rat tongue carcinomas and chemopreventive efficacy of a specific inhibitor, nimesulide.
Expression of cyclooxygenase (COX)-2 protein in 4-nitroquinoline-1-oxide (4-NQO)-induced rat tongue lesions and the… 
Highly Cited
2001
Highly Cited
2001
Insulin-like Growth Factor-I (IGF-I) Receptor Activation Rescues UV-damaged Cells through a p38 Signaling Pathway
The activated insulin-like growth factor-I receptor (IGF-IR) is implicated in mitogenesis, transformation, and anti-apoptosis. To… 
Highly Cited
1998
Highly Cited
1998
Multidrug resistance protein and glutathione S-transferase P1-1 act in synergy to confer protection from 4-nitroquinoline 1-oxide toxicity.
Model cell lines developed from MCF7 breast carcinoma cells were used to examine the roles of glutathione S-transferase P1-1… 
Highly Cited
1997
Highly Cited
1997
Detection of DNA lesions induced by chemical mutagens using the single-cell gel electrophoresis (comet) assay. 2. Relationship between DNA migration and alkaline condition.
Highly Cited
1988
Highly Cited
1988
X-ray- and chemically induced germ-line mutation causing phenotypical anomalies in mice.
Highly Cited
1984
Highly Cited
1984
Experimental induction of oral squamous cell carcinomas in mice with 4-nitroquinolone-1-oxide.
Highly Cited
1975
Highly Cited
1975
Caffeine inhibits cell transformation by 4-nitroquinoline-1-oxide
SOMATIC mutation has been considered a likely initiating step in chemical carcinogenesis1–3, chiefly because of the close… 
Highly Cited
1975
Highly Cited
1975
Seryl-tRNA synthetase and activation of the carcinogen 4-nitroquinoline 1-oxide
THE carcinogenic and mutagenic compound, 4-nitroquinoline 1-oxide (4NQO) and its reduced metabolite, 4-hydroxyaminoquinoline 1… 
Highly Cited
1973
Highly Cited
1973
Increased sensitivity of xeroderma pigmentosum cells to some chemical carcinogens and mutagens.
Highly Cited
1966
Highly Cited
1966
The metabolism of 4-nitroquinoline-1-oxide, a carcinogen. 3. An enzyme catalyzing the conversion of 4-nitroquinoline-1-oxide to 4-hydroxyaminoquinoline-1-oxide in rat liver and hepatomas.
Summary The activity of an enzyme that converts 4-nitroquinoline-1-oxide, a carcinogen, to 4-hydroxyaminoquinoline-1-oxide, a… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)