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3-methylxanthine

 
National Institutes of Health

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Related topics

1 relation

Broader (1)

Xanthines

Papers overview

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2015
2015
Direct conversion of theophylline to 3-methylxanthine by metabolically engineered E. coli
BackgroundMethylxanthines are natural and synthetic compounds found in many foods, drinks, pharmaceuticals, and cosmetics. Aside… Expand
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Highly Cited
2009
Highly Cited
2009
Two distinct pathways for metabolism of theophylline and caffeine are coexpressed in Pseudomonas putida CBB5.
Pseudomonas putida CBB5 was isolated from soil by enrichment on caffeine. This strain used not only caffeine, theobromine… Expand
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Highly Cited
2006
Highly Cited
2006
Caffeine metabolites are inhibitors of the nuclear enzyme poly(ADP-ribose)polymerase-1 at physiological concentrations.
The activity of the nuclear enzyme poly(ADP-ribose)polymerase-1 (E.C.2.4.2.30), which is highly activated by DNA strand breaks… Expand
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2005
2005
POSSIBLE INVOLVEMENT OF ORGANIC ANION TRANSPORTER 2 ON THE INTERACTION OF THEOPHYLLINE WITH ERYTHROMYCIN IN THE HUMAN LIVER
Organic anion transporter 2 (Oat2 [SLC22A7]) is a multispecific organic anion transporter. Although several substrates of human… Expand
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Highly Cited
2004
Highly Cited
2004
Degradation of caffeine and related methylxanthines bySerratia marcescens isolated from soil under coffee cultivation
A strain of Serratia marcescens showing the ability to degrade caffeine and other methylxanthines was isolated from soil under… Expand
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Highly Cited
1996
Highly Cited
1996
Theophylline metabolism in human liver microsomes: inhibition studies.
In this paper we describe the kinetics of formation of 1-methylxanthine (1-MX), 3-methylxanthine (3-MX) and 1,3-dimethyluric acid… Expand
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Highly Cited
1983
Highly Cited
1983
Subclasses of adenosine receptors in the central nervous system: Interaction with caffeine and related methylxanthines
Summary1.The potencies of caffeine and related methylxanthines as adenosine antagonists were assessed with respect to three… Expand
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1982
1982
Phenytoin-theophylline interaction.
Theophylline (1,3-dimethylxanthine) is a constituent of numerous bronchodilator preparations and is widely used in the treatment… Expand
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1979
1979
Influence of methylxanthine-containing foods on theophylline metabolism and kinetics.
The metabolism and kinetics of 14C-labeled theophylline have been studied after intravenous doses of 100 mg to healthy subjects… Expand
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Review
1978
Review
1978
Clinical Pharmacokinetics of Theophylline
SummaryKnowledge acquired of the kinetic disposition and effects of theophylline over the past 8 years has increased the clinical… Expand
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