D. Tocco

Publications34
h-index19
Citations1,846
Highly Influential Citations21
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On the mechanism of intestinal absorption of drugs.
The intestinal absorption of acidic drugs is decreased severalfold and the absorption of basic drugs increased severalfold when the pH of the intestinal contents is raised from 4 to 8. This supports… Expand
  • 417
  • 6
Absorption of drugs from the rat small intestine.
The relative rates of absorption of a large number of drugs have been measured by perfusing solutions of drugs through the entire small intestine of the anesthetized rat. A single perfusion of the… Expand
  • 348
  • 5
Timolol metabolism in man and laboratory anamals.
The two major urinary metabolites of 14C-timolol in man, involving oxidation and hydrolytic cleavage of the morpholine ring, are also observed in both Sprague-Dawley rats and CRCD-1 mice. These are… Expand
  • 22
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The physiological disposition and metabolism of enalapril maleate in laboratory animals.
N-[1-(S)-carboxy-3-phenylpropyl]-L-alanyl-L-proline (MK-422), is a potent angiotensin I-converting enzyme (ACE) inhibitor, but as a diacid is poorly absorbed in laboratory animals. Enalapril maleate,… Expand
  • 130
  • 1
Absorption of drugs from the stomach. II. The human.
The human stomach is capable of absorbing most acidic drugs and the very weakly basic drugs. Salicylic acid, aspirin, thiopental, secobarbital and antipyrine, which are undissociated in the acidic… Expand
  • 179
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Electron-capture GLC determination of timolol in human plasma and urine.
A GLC procedure was developed for measuring nanogram quantities of timolol in plasma and urine. The unchanged drug was extracted into heptane-4% isoamyl alcohol from alkalinized plasma or urine,… Expand
  • 39
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Assay methodology for quantification of the ester and ether glucuronide conjugates of diflunisal in human urine.
Diflunisal is a salicylate derivative with analgesic and anti-inflammatory properties. It is excreted in the urine as an ether glucuronide, a 1-O-acyl glucuronide and as unchanged drug. The 1-O-acyl… Expand
  • 34
  • 1
Diflunisal-induced maternal anemia as a cause of teratogenicity in rabbits.
Diflunisal [5-(2,4-difluorophenyl)-salicylic acid] is a new analgesic antiinflammatory drug that, when administered orally to rabbits at 40 and 60 mg/kg/day, caused terata, most commonly axial… Expand
  • 44
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Interspecies differences in stereoselective protein binding and clearance of MK-571.
(+)-3-(((3-(2-(7-chloro-2-quinolinyl)ethenyl)phenyl)((3-(dimethylamino)- 3-oxopropyl)thio)methyl)thio)propanoic acid (MK-571), is a potent and specific antagonist of leukotriene D4 action in vitro… Expand
  • 27
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Effect of experimental diabetes on elimination kinetics of diflunisal in rats.
The effects of insulin-deficient diabetes on the elimination of diflunisal were investigated in streptozotocin-treated rats. Diflunisal, a fluorinated salicylate with nonsteroidal antiinflammatory… Expand
  • 10
  • 1