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Methylxanthines, including caffeine and theophylline, are among the most widely consumed stimulant drugs in the world. These… Expand The natural plant alkaloids caffeine and theophylline were the first adenosine receptor (AR) antagonists described in the… Expand Adenosine is formed inside cells or on their surface, mostly by breakdown of adenine nucleotides. The formation of adenosine… Expand Editor's Note: This issue of In the Clinic has been updated. Diagnosis Migraine headache affects 18% of women and 6% of men… Expand Mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel cause cystic fibrosis. The ΔF508… Expand Abstract Four adenosine receptor subtypes of the family of G protein-coupled receptors, designated A1, A2A, A2B and A3 are… Expand In sensitized subjects, exposure to the mite allergen appears to be only one of several factors leading to asthma. We… Expand N6-Cyclohexyl[3H]adenosine ([3H]CHA) and 1,3-diethyl-8-[3H]phenylxanthine ([3H]DPX) to bind to adenosine receptors in brain… Expand The detection and measurement of adenosine 3’) 5’-phosphate are complicated by the extremely low levels present in most… Expand A sensitive method for the estimation of caffeine in biological material is described. The method is specific in that it does not… Expand