Pentoxifylline

Known as: 3,7-Dihydro-3,7-dimethyl-1-(5-oxohexyl)-1H-purine-2,6-dione, 1H-Purine-2,6-dione, 3,7-dihydro-3,7-dimethyl-1-(5-oxohexyl)-, Oxpentifylline 
A methylxanthine derivative with hemorrheologic and immunomodulating properties. Pentoxifylline inhibits phosphodiesterase, resulting in increased… (More)
National Institutes of Health

Related topics

Related topics

38 relations

Narrower (7)

8-oxolisofylline8-oxopentoxifyllineAgapurinBL-191
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Brain IschemiaCerebrovascular accidentDiabetic AngiopathiesDiabetic Neuropathies
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Broader (6)

Free Radical ScavengersPharmacologic SubstancePhosphodiesterase InhibitorsPlatelet Aggregation Inhibitors
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Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2016
Review
2016
Pathogenesis and novel treatment options for non-alcoholic steatohepatitis.
Non-alcoholic fatty liver disease affects 20-40% of the population. Its active form, non-alcoholic steatohepatitis (NASH), is… (More)
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Review
2016
Review
2016
Primary hyperparathyroidism: review and recommendations on evaluation, diagnosis, and management. A Canadian and international consensus
The purpose of this review is to assess the most recent evidence in the management of primary hyperparathyroidism (PHPT) and… (More)
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Highly Cited
2013
Highly Cited
2013
Prednisolone with vs without pentoxifylline and survival of patients with severe alcoholic hepatitis: a randomized clinical trial.
IMPORTANCE Prednisolone or pentoxifylline is recommended for severe alcoholic hepatitis, a life-threatening disease. The benefit… (More)
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Highly Cited
2011
Highly Cited
2011
Pentoxifylline improves nonalcoholic steatohepatitis: a randomized placebo-controlled trial.
UNLABELLED The primary aim of this study was to compare the effects of pentoxifylline (PTX) versus placebo on the histological… (More)
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Highly Cited
2005
Highly Cited
2005
Paclitaxel after doxorubicin plus cyclophosphamide as adjuvant chemotherapy for node-positive breast cancer: results from NSABP B-28.
PURPOSE The primary aim of National Surgical Adjuvant Breast and Bowel Project (NSABP) B-28 was to determine whether four cycles… (More)
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Highly Cited
2004
Highly Cited
2004
A Pilot Trial of Pentoxifylline in Nonalcoholic Steatohepatitis
OBJECTIVES:Tumor necrosis factor alpha (TNFα) contributes to liver damage and insulin resistance among patients with nonalcoholic… (More)
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Highly Cited
2000
Highly Cited
2000
Pentoxifylline improves short-term survival in severe acute alcoholic hepatitis: a double-blind, placebo-controlled trial.
BACKGROUND & AIMS An earlier pilot study from our liver unit suggested benefit from treatment with pentoxifylline (PTX), an… (More)
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Highly Cited
2000
Highly Cited
2000
A comparison of cilostazol and pentoxifylline for treating intermittent claudication.
PURPOSE We performed a randomized, double-blind, placebo-controlled, multicenter trial to evaluate the relative efficacy and… (More)
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Highly Cited
1991
Highly Cited
1991
Pentoxifylline suppression of tumor necrosis factor gene transcription.
Pentoxifylline decreases lung injury after intravenous endotoxin; the mechanism is unknown. Tumor necrosis factor-alpha (TNF) is… (More)
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Highly Cited
1990
Highly Cited
1990
Dexamethasone and pentoxifylline inhibit endotoxin-induced cachectin/tumor necrosis factor synthesis at separate points in the signaling pathway
The induction of cachectin/tumor necrosis factor (TNF) synthesis by bacterial endotoxins is a process that entails activation at… (More)
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