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Pentoxifylline
Known as:
3,7-Dihydro-3,7-dimethyl-1-(5-oxohexyl)-1H-purine-2,6-dione
, 1H-Purine-2,6-dione, 3,7-dihydro-3,7-dimethyl-1-(5-oxohexyl)-
, Oxpentifylline
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A methylxanthine derivative with hemorrheologic and immunomodulating properties. Pentoxifylline inhibits phosphodiesterase, resulting in increased…
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National Institutes of Health
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Related topics
Related topics
41 relations
Narrower (8)
8-oxolisofylline
8-oxopentoxifylline
Agapurin
BL-191
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Brain Ischemia
Cerebrovascular accident
Diabetic Angiopathies
Diabetic Neuropathies
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Broader (6)
Free Radical Scavengers
Pharmacologic Substance
Phosphodiesterase Inhibitors
Platelet Aggregation Inhibitors
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Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Review
2017
Review
2017
2016 AHA/ACC Guideline on the Management of Patients With Lower Extremity Peripheral Artery Disease: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical…
M. Gerhard-Herman
,
H. Gornik
,
+18 authors
M. E. Walsh
Journal of the American College of Cardiology
2017
Corpus ID: 35160076
Highly Cited
2015
Highly Cited
2015
Prednisolone or pentoxifylline for alcoholic hepatitis.
M. Thursz
,
P. Richardson
,
+20 authors
E. Forrest
The New England journal of medicine
2015
Corpus ID: 205097413
BACKGROUND Alcoholic hepatitis is a clinical syndrome characterized by jaundice and liver impairment that occurs in patients with…
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Highly Cited
2011
Highly Cited
2011
Pentoxifylline improves nonalcoholic steatohepatitis: A randomized placebo‐controlled trial
C. O. Zein
,
L. Yerian
,
+4 authors
A. McCullough
Hepatology
2011
Corpus ID: 23340673
The primary aim of this study was to compare the effects of pentoxifylline (PTX) versus placebo on the histological features of…
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Highly Cited
2011
Highly Cited
2011
Paclitaxel-Eluting Stents Show Superiority to Balloon Angioplasty and Bare Metal Stents in Femoropopliteal Disease: Twelve-Month Zilver PTX Randomized Study Results
M. Dake
,
G. Ansel
,
+11 authors
L. Machan
Circulation. Cardiovascular interventions
2011
Corpus ID: 28437014
Background— Sustained benefits of drug-eluting stents in femoropopliteal arteries have not been demonstrated. This prospective…
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Highly Cited
2005
Highly Cited
2005
Paclitaxel after doxorubicin plus cyclophosphamide as adjuvant chemotherapy for node-positive breast cancer: results from NSABP B-28.
E. Mamounas
,
J. Bryant
,
+7 authors
N. Wolmark
Journal of clinical oncology : official journal…
2005
Corpus ID: 24673118
PURPOSE The primary aim of National Surgical Adjuvant Breast and Bowel Project (NSABP) B-28 was to determine whether four cycles…
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Highly Cited
2003
Highly Cited
2003
Randomized, placebo-controlled trial of combined pentoxifylline and tocopherol for regression of superficial radiation-induced fibrosis.
S. Delanian
,
R. Porcher
,
S. Balla-Mekias
,
J. Lefaix
Journal of clinical oncology : official journal…
2003
Corpus ID: 9137225
PURPOSE Radiation-induced fibrosis (RIF) is a rare morbid complication of radiotherapy, without an established method of…
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Highly Cited
2000
Highly Cited
2000
Pentoxifylline improves short-term survival in severe acute alcoholic hepatitis: a double-blind, placebo-controlled trial.
E. Akriviadis
,
R. Botla
,
W. Briggs
,
S. Han
,
T. Reynolds
,
O. Shakil
Gastroenterology
2000
Corpus ID: 6601371
BACKGROUND & AIMS An earlier pilot study from our liver unit suggested benefit from treatment with pentoxifylline (PTX), an…
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Highly Cited
1995
Highly Cited
1995
Disruption of p53 function sensitizes breast cancer MCF-7 cells to cisplatin and pentoxifylline.
S. Fan
,
M. L. Smith
,
+5 authors
P. O'Connor
Cancer research
1995
Corpus ID: 25552611
The possibility that appropriately designed chemotherapy could act selectively against p53-defective tumor cells was explored in…
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Highly Cited
1990
Highly Cited
1990
Dexamethasone and pentoxifylline inhibit endotoxin-induced cachectin/tumor necrosis factor synthesis at separate points in the signaling pathway
J. Han
,
P. Thompson
,
B. Beutler
The Journal of experimental medicine
1990
Corpus ID: 7272755
The induction of cachectin/tumor necrosis factor (TNF) synthesis by bacterial endotoxins is a process that entails activation at…
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Review
1987
Review
1987
Pentoxifylline. A review of its pharmacodynamic and pharmacokinetic properties, and its therapeutic efficacy.
A. Ward
,
S. Clissold
Drugs
1987
Corpus ID: 195697501
Pentoxifylline (oxpentifylline) is an orally active haemorheological agent for the treatment of peripheral vascular disease…
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