Pentoxifylline

Known as: 3,7-Dihydro-3,7-dimethyl-1-(5-oxohexyl)-1H-purine-2,6-dione, 1H-Purine-2,6-dione, 3,7-dihydro-3,7-dimethyl-1-(5-oxohexyl)-, Oxpentifylline 
A methylxanthine derivative with hemorrheologic and immunomodulating properties. Pentoxifylline inhibits phosphodiesterase, resulting in increased… (More)
National Institutes of Health

Papers overview

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Review
2016
Review
2016
Non-alcoholic fatty liver disease affects 20-40% of the population. Its active form, non-alcoholic steatohepatitis (NASH), is… (More)
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Review
2016
Review
2016
The purpose of this review is to assess the most recent evidence in the management of primary hyperparathyroidism (PHPT) and… (More)
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Highly Cited
2013
Highly Cited
2013
IMPORTANCE Prednisolone or pentoxifylline is recommended for severe alcoholic hepatitis, a life-threatening disease. The benefit… (More)
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Highly Cited
2011
Highly Cited
2011
UNLABELLED The primary aim of this study was to compare the effects of pentoxifylline (PTX) versus placebo on the histological… (More)
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Highly Cited
2005
Highly Cited
2005
PURPOSE The primary aim of National Surgical Adjuvant Breast and Bowel Project (NSABP) B-28 was to determine whether four cycles… (More)
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Highly Cited
2004
Highly Cited
2004
OBJECTIVES:Tumor necrosis factor alpha (TNFα) contributes to liver damage and insulin resistance among patients with nonalcoholic… (More)
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Highly Cited
2000
Highly Cited
2000
BACKGROUND & AIMS An earlier pilot study from our liver unit suggested benefit from treatment with pentoxifylline (PTX), an… (More)
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Highly Cited
2000
Highly Cited
2000
PURPOSE We performed a randomized, double-blind, placebo-controlled, multicenter trial to evaluate the relative efficacy and… (More)
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Highly Cited
1991
Highly Cited
1991
Pentoxifylline decreases lung injury after intravenous endotoxin; the mechanism is unknown. Tumor necrosis factor-alpha (TNF) is… (More)
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Highly Cited
1990
Highly Cited
1990
The induction of cachectin/tumor necrosis factor (TNF) synthesis by bacterial endotoxins is a process that entails activation at… (More)
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