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Pentoxifylline

Known as: 3,7-Dihydro-3,7-dimethyl-1-(5-oxohexyl)-1H-purine-2,6-dione, 1H-Purine-2,6-dione, 3,7-dihydro-3,7-dimethyl-1-(5-oxohexyl)-, Oxpentifylline 
A methylxanthine derivative with hemorrheologic and immunomodulating properties. Pentoxifylline inhibits phosphodiesterase, resulting in increased… 
National Institutes of Health

Related topics

Related topics

41 relations

Narrower (8)

8-oxolisofylline8-oxopentoxifyllineAgapurinBL-191
Brain IschemiaCerebrovascular accidentDiabetic AngiopathiesDiabetic Neuropathies

Broader (6)

Free Radical ScavengersPharmacologic SubstancePhosphodiesterase InhibitorsPlatelet Aggregation Inhibitors

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2017
Review
2017
2016 AHA/ACC Guideline on the Management of Patients With Lower Extremity Peripheral Artery Disease: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical…
Highly Cited
2015
Highly Cited
2015
Prednisolone or pentoxifylline for alcoholic hepatitis.
BACKGROUND Alcoholic hepatitis is a clinical syndrome characterized by jaundice and liver impairment that occurs in patients with… 
Highly Cited
2011
Highly Cited
2011
Pentoxifylline improves nonalcoholic steatohepatitis: A randomized placebo‐controlled trial
The primary aim of this study was to compare the effects of pentoxifylline (PTX) versus placebo on the histological features of… 
Highly Cited
2011
Highly Cited
2011
Paclitaxel-Eluting Stents Show Superiority to Balloon Angioplasty and Bare Metal Stents in Femoropopliteal Disease: Twelve-Month Zilver PTX Randomized Study Results
Background— Sustained benefits of drug-eluting stents in femoropopliteal arteries have not been demonstrated. This prospective… 
Highly Cited
2005
Highly Cited
2005
Paclitaxel after doxorubicin plus cyclophosphamide as adjuvant chemotherapy for node-positive breast cancer: results from NSABP B-28.
PURPOSE The primary aim of National Surgical Adjuvant Breast and Bowel Project (NSABP) B-28 was to determine whether four cycles… 
Highly Cited
2003
Highly Cited
2003
Randomized, placebo-controlled trial of combined pentoxifylline and tocopherol for regression of superficial radiation-induced fibrosis.
PURPOSE Radiation-induced fibrosis (RIF) is a rare morbid complication of radiotherapy, without an established method of… 
Highly Cited
2000
Highly Cited
2000
Pentoxifylline improves short-term survival in severe acute alcoholic hepatitis: a double-blind, placebo-controlled trial.
BACKGROUND & AIMS An earlier pilot study from our liver unit suggested benefit from treatment with pentoxifylline (PTX), an… 
Highly Cited
1995
Highly Cited
1995
Disruption of p53 function sensitizes breast cancer MCF-7 cells to cisplatin and pentoxifylline.
The possibility that appropriately designed chemotherapy could act selectively against p53-defective tumor cells was explored in… 
Highly Cited
1990
Highly Cited
1990
Dexamethasone and pentoxifylline inhibit endotoxin-induced cachectin/tumor necrosis factor synthesis at separate points in the signaling pathway
The induction of cachectin/tumor necrosis factor (TNF) synthesis by bacterial endotoxins is a process that entails activation at… 
Review
1987
Review
1987
Pentoxifylline. A review of its pharmacodynamic and pharmacokinetic properties, and its therapeutic efficacy.
Pentoxifylline (oxpentifylline) is an orally active haemorheological agent for the treatment of peripheral vascular disease… 
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