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Pentoxifylline

Known as: 3,7-Dihydro-3,7-dimethyl-1-(5-oxohexyl)-1H-purine-2,6-dione, 1H-Purine-2,6-dione, 3,7-dihydro-3,7-dimethyl-1-(5-oxohexyl)-, Oxpentifylline 
A methylxanthine derivative with hemorrheologic and immunomodulating properties. Pentoxifylline inhibits phosphodiesterase, resulting in increased… 
National Institutes of Health

Related topics

Related topics

41 relations

Narrower (8)

8-oxolisofylline8-oxopentoxifyllineAgapurinBL-191
Brain IschemiaCerebrovascular accidentDiabetic AngiopathiesDiabetic Neuropathies

Broader (6)

Free Radical ScavengersPharmacologic SubstancePhosphodiesterase InhibitorsPlatelet Aggregation Inhibitors

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2007
Review
2007
Future strategies for mitigation and treatment of chronic radiation-induced normal tissue injury.
Highly Cited
2007
Highly Cited
2007
TNF-α blockade decreases oxidative stress in the paraventricular nucleus and attenuates sympathoexcitation in heart failure rats
Oxidative stress plays an important role in the pathophysiology of cardiovascular disease. Recent evidence suggests that… 
Highly Cited
2007
Highly Cited
2007
Parathyroidectomy reduces cardiovascular events and mortality in renal hyperparathyroidism.
Review
2005
Review
2005
Early introduction of lipids to parenterally-fed preterm infants.
BACKGROUND Lipids are essential components of parenteral nutrition for preterm infants. Parenteral lipids can be administered… 
Highly Cited
2004
Highly Cited
2004
Pentoxifylline in the treatment of radiation-induced fibrosis.
PURPOSE Fibrotic sequelae remain the most important dose-limiting toxicity of radiation therapy to soft tissue. Functionally… 
Highly Cited
2003
Highly Cited
2003
Pertussis Toxin Enhances Th1 Responses by Stimulation of Dendritic Cells 1
Pertussis toxin (PTX) has been widely used as an adjuvant to induce Th1-mediated organ-specific autoimmune diseases in animal… 
Highly Cited
2000
Highly Cited
2000
ATP inhibits glutamate synaptic release by acting at P2Y receptors in pyramidal neurons of hippocampal slices.
It has been proposed that extracellular ATP inhibits synaptic release of glutamate from hippocampal CA1 synapses after its… 
Review
1998
Review
1998
Anticytokine approaches to the treatment of anorexia and cachexia.
Proinflammatory cytokines such as tumor necrosis factor-alpha (TNF-alpha) have a prominent role in the pathogenesis of anorexia… 
Highly Cited
1989
Highly Cited
1989
OXPENTIFYLLINE IN ENDOTOXAEMIA
Highly Cited
1976
Highly Cited
1976
Improvement of the Flow Properties of Blood: a New Therapeutical Approach in Occlusive Arterial Disease
The general pathophysiological basis in occlusive arterial disease is the reduced flow rate of blood in the microcirculation… 
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