Pharmacologic Substance

Known as: Drug Substance, Drug, Pharmacological Substance 
Any natural, endogenously-derived, synthetic or semi-synthetic compound with pharmacologic activity. A pharmacologic substance has one or more… (More)
National Institutes of Health

Papers overview

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Review
2017
Review
2017
Immunotherapy using chimeric antigen receptor-modified T cells has demonstrated high response rates in patients with B cell… (More)
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Highly Cited
2015
Highly Cited
2015
AIMS To compare the efficacy [low-density lipoprotein cholesterol (LDL-C) lowering] and safety of alirocumab, a fully human… (More)
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Review
2011
Review
2011
A significant percentage of active pharmaceutical ingredients identified through discovery screening programs is poorly soluble… (More)
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Highly Cited
2010
Highly Cited
2010
BACKGROUND Most patients with type 2 diabetes begin pharmacotherapy with metformin, but eventually need additional treatment. We… (More)
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Highly Cited
2010
Highly Cited
2010
BACKGROUND Diabetes treatments are needed that are convenient, provide effective glycaemic control, and do not cause weight gain… (More)
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Review
2010
Review
2010
The initial identification of glucagon as a counter-regulatory hormone to insulin revealed this hormone to be of largely singular… (More)
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Highly Cited
2009
Highly Cited
2009
A pathological hallmark of Alzheimer’s disease is an accumulation of insoluble plaque containing the amyloid-β peptide of 40–42… (More)
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Highly Cited
2008
Highly Cited
2008
CONTEXT Use and abuse of prescription narcotic analgesics have increased dramatically in the United States since 1990. The effect… (More)
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Review
2008
Review
2008
More than 40% of compounds identified through combinatorial screening programs are poorly soluble in water. These molecules are… (More)
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Highly Cited
2002
Highly Cited
2002
OBJECTIVE The purpose of this study was to assess the efficacy and safety of duloxetine, a selective inhibitor of serotonin and… (More)
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