• Publications
  • Influence
Urinary bladder contraction and relaxation: physiology and pathophysiology.
TLDR
The aim of this review is to summarize and synthesize basic information and recent advances in the understanding of the properties of the detrusor smooth muscle, its contractile system, cellular signaling, membrane properties, and cellular receptors.
Fourth international consultation on incontinence recommendations of the international scientific committee: Evaluation and treatment of urinary incontinence, pelvic organ prolapse, and fecal
P. Abrams , K.E. Andersson, L. Birder, L. Brubaker, L. Cardozo, C. Chapple, A. Cottenden, W. Davila, D. de Ridder, R. Dmochowski, M. Drake, C. DuBeau, C. Fry, P. Hanno, J. Hay Smith, S. Herschorn, G.
Pharmacology of the Lower Urinary Tract: Basis for Current and Future Treatments of Urinary Incontinence
TLDR
Antimuscarinics are the main-stay of pharmacological treatment of the overactive bladder syndrome, which is characterized by urgency, frequency, and urge incontinence.
Urothelial signaling.
TLDR
Changes in the urothelium/lamina propria ("mucosa") produced by different bladder disorders are discussed, as well as the mucosa as a target for therapeutic interventions.
Pharmacology of penile erection.
  • K. Andersson
  • Biology, Medicine
    Pharmacological reviews
  • 1 September 2001
TLDR
Dopamine receptors in central nervous centers participating in the initiation of erection have been targeted for the treatment of ED, and Apomorphine, administered sublingually, is the first of such drugs.
EAU guidelines on urinary incontinence.
The vasodilator‐stimulated phosphoprotein (VASP) is involved in cGMP‐ and cAMP‐mediated inhibition of agonist‐induced platelet aggregation, but is dispensable for smooth muscle function
TLDR
Data show that two different cyclic, nucleotide‐dependent mechanisms are operating during platelet activation: a VASP‐independent mechanism for inhibition of calcium mobilization and granule release and a VasP‐dependent mechanism forhibition of platelet aggregation which may involve regulation of integrin function.
Muscarinic receptors: their distribution and function in body systems, and the implications for treating overactive bladder
TLDR
The evolving understanding of muscarinic receptor functions throughout the body is explored, with particular focus on the bladder, gastrointestinal tract, eye, heart, brain and salivary glands, and the implications for drugs used to treat OAB.
Mechanisms of Penile Erection and Basis for Pharmacological Treatment of Erectile Dysfunction
  • K. Andersson
  • Biology, Medicine
    Pharmacological Reviews
  • 1 December 2011
TLDR
Erectile dysfunction (ED), defined as the “inability to achieve or maintain an erection adequate for sexual satisfaction,” may have multiple causes and can be classified as psychogenic, vasculogenic or organic, neurologic, and endocrinologic.
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