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3-hydroxyquinidine

Known as: 3-hydroxyquinine, 6'-methoxycinchonan-3,9-diol 
National Institutes of Health

Papers overview

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2009
2009
The use of herbal supplements has increased dramatically, making drug interactions with these supplements a major concern… 
Highly Cited
2003
Highly Cited
2003
ObjectivesThe aims were to investigate: (1) The renal elimination of quinine and its metabolites 3-hydoxyquinine, 2′-quininone… 
Highly Cited
2000
Highly Cited
2000
Prolongation of the electrocardiographic QT interval by drugs is associated with the occurrence of a potentially lethal form of… 
Highly Cited
1997
Highly Cited
1997
AbstractObjective: To assess the factors that contribute to impaired quinine clearance in acute falciparum malaria. Patients… 
Highly Cited
1997
Highly Cited
1997
AIMS Our previous studies using in vitro hepatic microsomal preparations suggested that the hepatic metabolism of quinine to form… 
Highly Cited
1997
Highly Cited
1997
Highly Cited
1997
Highly Cited
1997
The major metabolic pathway of quinine in the human has been shown to be 3-hydroxylation mediated mainly by human cytochrome P450… 
Highly Cited
1996
Highly Cited
1996
Studies using human liver microsomes and nine recombinant human cytochrome P450 (CYP) isoforms (CYP1A1, 1A2, 2A6, 2B6, 2C9, 2C19… 
1995
1995
Our previous studies have shown that cigarette smoking and rifampicin pretreatment enhance the elimination of quinine, metabolism… 
Highly Cited
1986
Highly Cited
1986