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To evaluate the pharmacokinetic interactions between ritonavir and quinine in healthy volunteers.
Ten healthy… Expand The use of herbal supplements has increased dramatically, making drug interactions with these supplements a major concern… Expand A simple high-performance liquid chromatographic method for the simultaneous analysis of quinine and 3-hydroxyquinine in blood… Expand ObjectivesThe aims were to investigate: (1) The renal elimination of quinine and its metabolites 3-hydoxyquinine, 2′-quininone… Expand Prolongation of the electrocardiographic QT interval by drugs is associated with the occurrence of a potentially lethal form of… Expand AIMS
Our previous studies using in vitro hepatic microsomal preparations suggested that the hepatic metabolism of quinine to form… Expand Quinidine is eliminated mainly by CYP3A4‐mediated metabolism. Itraconazole interacts with some but not all of the substrates of… Expand AbstractObjective: To assess the factors that contribute to impaired quinine clearance in acute falciparum malaria.
Patients… Expand Studies using human liver microsomes and nine recombinant human cytochrome P450 (CYP) isoforms (CYP1A1, 1A2, 2A6, 2B6, 2C9, 2C19… Expand Our previous studies have shown that cigarette smoking and rifampicin pretreatment enhance the elimination of quinine, metabolism… Expand