Mefloquine resistance in Plasmodium falciparum and increased pfmdr1 gene copy number
- R. Price, A. Uhlemann, S. Krishna
- MedicineThe Lancet
- 31 July 2004
Melioidosis: a major cause of community-acquired septicemia in northeastern Thailand.
- W. Chaowagul, N. White, N. Pitakwatchara
- MedicineJournal of Infectious Diseases
- 1 May 1989
Septicemic melioidosis presented mainly in the rainy season, occurred predominantly in rice farmers or their families, and was significantly associated with preexisting diabetes mellitus or renal failure, and the mortality was high.
Sensitive and inexpensive molecular test for falciparum malaria: detecting Plasmodium falciparum DNA directly from heat-treated blood by loop-mediated isothermal amplification.
- L. Poon, B. W. Wong, J. Peiris
- MedicineClinical Chemistry
- 1 February 2006
The LAMP assay does not require purified DNA for efficient DNA amplification, thereby reducing the cost and turnaround time for P. falciparum diagnosis, and requires only basic instruments, and assay positivity can be verified by visual inspection.
Human cerebral malaria. A quantitative ultrastructural analysis of parasitized erythrocyte sequestration.
- G. Macpherson, M. Warrell, N. White, S. Looareesuwan, D. Warrell
- Medicine, BiologyAmerican Journal of Pathology
- 1 June 1985
It is concluded that there is no evidence for an inflammatory or immune pathogenesis for human cerebral malaria and that the clinical effects probably relate to anoxia and the metabolic activities of the parasites.
Malaria Blood Stage Parasites Activate Human Plasmacytoid Dendritic Cells and Murine Dendritic Cells through a Toll-Like Receptor 9-Dependent Pathway1
- S. Pichyangkul, K. Yongvanitchit, R. Miller
- Biology, MedicineJournal of Immunology
- 15 April 2004
Results demonstrate that schizont extracts contain a novel and previously unknown ligand for TLR9 and suggest that the stimulatory effects of this ligand on PDCs may play a key role in immunoregulation and immunopathogenesis of human falciparum malaria.
Practical PCR genotyping protocols for Plasmodium vivax using Pvcs and Pvmsp1
- M. Imwong, S. Pukrittayakamee, G. Snounou
- MedicineMalaria Journal
- 27 April 2005
Results indicate that the genotyping protocols presented can be useful in the assessment of in vivo drug efficacy clinical trials conducted in endemic areas and for epidemiological studies of P. vivax infections.
Clinical studies of atovaquone, alone or in combination with other antimalarial drugs, for treatment of acute uncomplicated malaria in Thailand.
- S. Looareesuwan, C. Viravan, H. Webster, D. Kyle, D. Hutchinson, C. Canfield
- MedicineAmerican Journal of Tropical Medicine and Hygiene
- 1996
Of the 104 patients with falciparum malaria treated with atovaquone plus proguanil for 3-7 days, 101 were cured and had virtually no adverse side effects, but parasitemia recurred in most patients.
Pharmacokinetics and Pharmacodynamics of Lumefantrine (Benflumetol) in Acute Falciparum Malaria
- F. Ezzet, M. van Vugt, F. Nosten, S. Looareesuwan, N. White
- MedicineAntimicrobial Agents and Chemotherapy
- 1 March 2000
Lumefantrine oral bioavailability is very dependent on food and is consequently poor in acute malaria but improves markedly with recovery, and the high cure rates with the two six-dose regimens resulted from increased AUC and increased time at which lumefanrine concentrations were above the in vivo MIC.
A clinical and pharmacokinetic trial of six doses of artemether-lumefantrine for multidrug-resistant Plasmodium falciparum malaria in Thailand.
- G. Lefèvre, S. Looareesuwan, R. Bakshi
- MedicineAmerican Journal of Tropical Medicine and Hygiene
- 1 May 2001
The efficacy-safety and pharmacokinetics of the six-dose regimen of artemether-lumefantrine (Coartem/Riamet; Novartis Pharma AG, Basel, Switzerland) were assessed in a randomized trial in 219…
...
...