Quinidine

Known as: (S)-(6-Methoxyquinolin-4-yl)((2R,5R)-5-vinylquinuclidin-2-yl)methanol, Chinidinum, Cinchonan-9-ol, 6'-methoxy-, (9S)- 
An alkaloid extracted from the bark of the Cinchona tree with class 1A antiarrhythmic and antimalarial effects. Quinidine stabilizes the neuronal… (More)
National Institutes of Health

Papers overview

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Highly Cited
2010
Highly Cited
2010
OBJECTIVE To evaluate dextromethorphan combined with ultra low-dose quinidine (DMq) for treating pseudobulbar affect (PBA) in… (More)
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Highly Cited
2007
Highly Cited
2007
BACKGROUND Cardiac ion channelopathies are responsible for an ever-increasing number and diversity of familial cardiac arrhythmia… (More)
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Highly Cited
2006
Highly Cited
2006
Relatively few selective substrate and inhibitor probes have been identified for human UDP-glucuronosyltransferases (UGTs). This… (More)
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Highly Cited
2003
Highly Cited
2003
BACKGROUND Tamoxifen, a selective estrogen receptor modulator (SERM), is converted to 4-hydroxy-tamoxifen and other active… (More)
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Highly Cited
1999
Highly Cited
1999
BACKGROUND Although quinidine is known to elevate plasma digoxin concentrations, the mechanism underlying this interaction is not… (More)
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Highly Cited
1999
Highly Cited
1999
BACKGROUND The Brugada syndrome is characterized by marked ST-segment elevation in the right precordial ECG leads and is… (More)
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Highly Cited
1992
Highly Cited
1992
The interaction of quinidine with a cloned human cardiac potassium channel (HK2) expressed in a stable mouse L cell line was… (More)
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Highly Cited
1986
Highly Cited
1986
The anti-arrhythmic quinidine has been reported to be a competitive inhibitor of the catalytic activities of human liver P-450DB… (More)
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Highly Cited
1985
Highly Cited
1985
Marked QT prolongation with induction of polymorphous ventricular tachycardia ("Torsades de Pointes") is a well-described… (More)
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Highly Cited
1984
Highly Cited
1984
Quinidine, which has antiarrhythmic activity, greatly enhanced the cytotoxicity of vincristine (VCR) in tumor cells and… (More)
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