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Efficacies of liposome-encapsulated clarithromycin and ofloxacin against Mycobacterium avium-M. intracellulare complex in human macrophages.
- C. Onyeji, C. Nightingale, D. Nicolau, R. Quintiliani
- Biology, Medicine
- Antimicrobial Agents and Chemotherapy
- 1 March 1994
The therapeutic efficacies of liposome-encapsulated ofloxacin and clarithromycin against Mycobacterium avium-M. intracellulare (MAI) were evaluated in a model of intramacrophage infection. Liposome… Expand
Enhanced killing of methicillin-resistantStaphylococcus aureus in human macrophages by liposome-entrapped vancomycin and teicoplanin
SummaryThe antibacterial effects of liposomal vancomycin and teicoplanin against intracellular methicillin-resistantStaphylococcus aureus (MRSA) were evaluated using a macrophage infection model.… Expand
Evidence for increased metabolism of chloroquine during the early third trimester of human pregnancy
- Mercilina C Chukwuani, O. Bolaji, C. Onyeji, O. Makinde, F. Ogunbona
- Tropical medicine & international health : TM…
- 1 May 2004
Objective To examine the possibility of a different extent of chloroquine (CQ) metabolism in human pregnancy by determining blood level profiles of the drug and its major metabolite,… Expand
Pharmacokinetic interactions between ritonavir and quinine in healthy volunteers following concurrent administration.
- J. Soyinka, C. Onyeji, S. I. Omoruyi, A. R. Owolabi, P. V. Sarma, J. M. Cook
- British journal of clinical pharmacology
- 1 March 2010
AIMS To evaluate the pharmacokinetic interactions between ritonavir and quinine in healthy volunteers. METHODS Ten healthy volunteers were each given 600-mg single oral doses of quinine alone,… Expand
Alteration of pharmacokinetics of proguanil in healthy volunteers following concurrent administration of efavirenz.
Efavirenz and proguanil are likely to be administered concurrently for the treatment of patients with HIV and malaria. The metabolism of proguanil is mediated principally by CYP2C19 while efavirenz… Expand
Ion-pair reversed-phase high-performance liquid chromatographic analysis of halofantrine and desbutylhalofantrine in human plasma.
A new ion-pair reversed-phase high-performance liquid chromatographic (HPLC) method for the simultaneous measurements of halofantrine (HF) and its major metabolite, desbutylhalofantrine (Hfm), in… Expand
Influence of adjunctive interferon-gamma on treatment of gentamicin- and vancomycin-resistant Enterococcus faecalis infection in mice.
- C. Onyeji, K. Bui, D. Nicolau, C. Nightingale, L. Bow, R. Quintiliani
- International journal of antimicrobial agents
- 1 August 1999
Increasing antibiotic resistance and the development of multidrug-resistance in the enterococci has complicated the treatment of serious enterococcal infections. It has been demonstrated in vitro… Expand
Altered pharmacokinetics of halofantrine by an antacid, magnesium carbonate.
- S. O. Aideloje, C. Onyeji, N. Ugwu
- Chemistry, Medicine
- European journal of pharmaceutics and…
- 1 November 1998
This study investigated the in vitro adsorption of halofantrine (Hf) by some antacids. Magnesium carbonate showed the highest adsorptive effect, the extent of adsorption being up to 83%. Only 4% of… Expand
Effects of absorption enhancers in chloroquine suppository formulations: I. In vitro release characteristics.
- C. Onyeji, A. Adebayo, C. Babalola
- Medicine, Chemistry
- European journal of pharmaceutical sciences…
- 1 December 1999
The need to develop chloroquine suppository formulations that yield optimal bioavailability of the drug has been emphasized. This study demonstrates the effects of incorporation of known… Expand
Pharmacokinetics of Ticlopidine in the Rabbit
- C. Onyeji, P. Tessier, C. Nightingale, F. Vallée, D. Nicolau
- Chemistry, Medicine
- The Journal of pharmacy and pharmacology
- 1 April 1999
There is no information about the pharmacokinetics of ticlopidine in rabbits. Such information is valuable in designing appropriate dosing regimens for experimental studies of the drug with ultimate… Expand