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Efficacies of liposome-encapsulated clarithromycin and ofloxacin against Mycobacterium avium-M. intracellulare complex in human macrophages.
The therapeutic efficacies of liposome-encapsulated ofloxacin and clarithromycin against Mycobacterium avium-M. intracellulare (MAI) were evaluated in a model of intramacrophage infection. LiposomeExpand
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Enhanced killing of methicillin-resistantStaphylococcus aureus in human macrophages by liposome-entrapped vancomycin and teicoplanin
SummaryThe antibacterial effects of liposomal vancomycin and teicoplanin against intracellular methicillin-resistantStaphylococcus aureus (MRSA) were evaluated using a macrophage infection model.Expand
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Evidence for increased metabolism of chloroquine during the early third trimester of human pregnancy
Objective  To examine the possibility of a different extent of chloroquine (CQ) metabolism in human pregnancy by determining blood level profiles of the drug and its major metabolite,Expand
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Pharmacokinetic interactions between ritonavir and quinine in healthy volunteers following concurrent administration.
AIMS To evaluate the pharmacokinetic interactions between ritonavir and quinine in healthy volunteers. METHODS Ten healthy volunteers were each given 600-mg single oral doses of quinine alone,Expand
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Altered pharmacokinetics of halofantrine by an antacid, magnesium carbonate.
This study investigated the in vitro adsorption of halofantrine (Hf) by some antacids. Magnesium carbonate showed the highest adsorptive effect, the extent of adsorption being up to 83%. Only 4% ofExpand
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Alteration of pharmacokinetics of proguanil in healthy volunteers following concurrent administration of efavirenz.
  • J. Soyinka, C. Onyeji
  • Chemistry, Medicine
  • European journal of pharmaceutical sciences…
  • 19 February 2010
Efavirenz and proguanil are likely to be administered concurrently for the treatment of patients with HIV and malaria. The metabolism of proguanil is mediated principally by CYP2C19 while efavirenzExpand
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Influence of adjunctive interferon-gamma on treatment of gentamicin- and vancomycin-resistant Enterococcus faecalis infection in mice.
Increasing antibiotic resistance and the development of multidrug-resistance in the enterococci has complicated the treatment of serious enterococcal infections. It has been demonstrated in vitroExpand
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Ion-pair reversed-phase high-performance liquid chromatographic analysis of halofantrine and desbutylhalofantrine in human plasma.
A new ion-pair reversed-phase high-performance liquid chromatographic (HPLC) method for the simultaneous measurements of halofantrine (HF) and its major metabolite, desbutylhalofantrine (Hfm), inExpand
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Dissolution properties and characterization of halofantrine-2-hydroxypropyl-beta-cyclodextrin binary systems.
Halofantrine (HF) is a poorly water-soluble antimalarial drug with low bioavailability. Complex formation of HF.HCl and 2-hydroxypropyl-beta-cyclodextrin (HP-beta-CD) in aqueous solution and in solidExpand
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Effects of absorption enhancers in chloroquine suppository formulations: I. In vitro release characteristics.
The need to develop chloroquine suppository formulations that yield optimal bioavailability of the drug has been emphasized. This study demonstrates the effects of incorporation of knownExpand
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