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3,4-dihydroxybenzohydroxamic acid

Known as: Benzamide, N,3,4-trihydroxy-, Didox, N,3,4-trihydroxybenzamide 
A ribonucleotide reductase inhibitor with activity against retroviruses. Didox inhibits retrovirus replication by depleting the deoxynucleotides… 
National Institutes of Health

Related topics

Related topics

3 relations

Broader (3)

Antineoplastic AgentsEnzyme InhibitorsHydroxamic Acids

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2016
2016
Compromised axon initial segment integrity in EAE is preceded by microglial reactivity and contact
Axonal pathology is a key contributor to long‐term disability in multiple sclerosis (MS), an inflammatory demyelinating disease… 
2016
2016
Didox and resveratrol sensitize colorectal cancer cells to doxorubicin via activating apoptosis and ameliorating P-glycoprotein activity
Doxorubicin (DOX) has limited efficacy in colorectal cancer due to multi-drug resistance. Resveratrol (RES) and didox (DID) are… 
2015
2015
Targeting Ribonucleotide Reductase M2 and NF-κB Activation with Didox to Circumvent Tamoxifen Resistance in Breast Cancer
Tamoxifen is widely used as an adjuvant therapy for patients with estrogen receptor (ERα)–positive tumors. However, the clinical… 
2013
2013
AKT-Induced Tamoxifen Resistance Is Overturned by RRM2 Inhibition
Acquired tamoxifen resistance develops in the majority of hormone-responsive breast cancers and frequently involves… 
2013
2013
Didox potentiates the cytotoxic profile of doxorubicin and protects from its cardiotoxicity.
2004
2004
Biochemical and antitumor activity of trimidox, a new inhibitor of ribonucleotide reductase
Trimidox (3,4,5-trihydroxybenzamidoxime), a newly synthesized analog of didox (N,3,4-trihydroxybenzamide) reduced the activity of… 
Highly Cited
2003
Highly Cited
2003
Oxidative stress in HIV demented patients and protection ex vivo with novel antioxidants
Objective: To determine the role of oxidative stress in mediating HIV dementia and to identify novel therapeutic compounds that… 
Highly Cited
2003
Highly Cited
2003
Down-regulation of deoxycytidine kinase in human leukemic cell lines resistant to cladribine and clofarabine and increased ribonucleotide reductase activity contributes to fludarabine resistance.
1988
1988
A phase 1 and pharmacokinetic study of didox: a ribonucleotide reductase inhibitor.
A phase 1 study of a new ribonucleotide reductase inhibitor, didox, was performed by administration of escalating doses of the… 
Highly Cited
1980
Highly Cited
1980
Regulation of ribonucleotide reductase in mammalian cells by chemotherapeutic agents.
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