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3,4-dihydroxybenzohydroxamic acid

Known as: Benzamide, N,3,4-trihydroxy-, Didox, N,3,4-trihydroxybenzamide 
A ribonucleotide reductase inhibitor with activity against retroviruses. Didox inhibits retrovirus replication by depleting the deoxynucleotides… Expand
National Institutes of Health

Papers overview

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2016
2016
Axonal pathology is a key contributor to long-term disability in multiple sclerosis (MS), an inflammatory demyelinating disease… Expand
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2016
2016
Doxorubicin (DOX) has limited efficacy in colorectal cancer due to multi-drug resistance. Resveratrol (RES) and didox (DID) are… Expand
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2015
2015
Didox (3,4-dihydroxy-benzohydroxamic acid), is a synthetic ribonucleotide reductase (RR) inhibitor derived from polyhydroxy… Expand
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2013
2013
Ganciclovir (GCV) is a deoxyguanosine analog that is effective in inhibiting human cytomegalovirus (HCMV) replication. In… Expand
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2006
2006
OBJECTIVE Clinically, the vascular pathobiology of human sickle cell disease includes an abnormal state of chronic inflammation… Expand
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Highly Cited
2003
Highly Cited
2003
Objective: To determine the role of oxidative stress in mediating HIV dementia and to identify novel therapeutic compounds that… Expand
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2003
2003
PurposeTemozolomide (TMZ), an oral alkylating agent with good penetration of the blood-brain barrier, has shown efficacy in the… Expand
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2001
2001
OBJECTIVE Amidox and didox are two polyhydroxy-substituted benzohydroxamic acid derivatives that belong to a new class of… Expand
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1988
1988
A phase 1 study of a new ribonucleotide reductase inhibitor, didox, was performed by administration of escalating doses of the… Expand
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