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3,4-dihydroxybenzohydroxamic acid

Known as: Benzamide, N,3,4-trihydroxy-, Didox, N,3,4-trihydroxybenzamide 
A ribonucleotide reductase inhibitor with activity against retroviruses. Didox inhibits retrovirus replication by depleting the deoxynucleotides… Expand
National Institutes of Health

Papers overview

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2016
2016
Axonal pathology is a key contributor to long‐term disability in multiple sclerosis (MS), an inflammatory demyelinating disease… Expand
2015
2015
Tamoxifen is widely used as an adjuvant therapy for patients with estrogen receptor (ERα)–positive tumors. However, the clinical… Expand
2013
2013
Acquired tamoxifen resistance develops in the majority of hormone-responsive breast cancers and frequently involves… Expand
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2013
2013
The use of adjuvant therapies in cancer treatment is rationalized by potentiating the efficacy and/or protecting from the major… Expand
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2004
2004
Trimidox (3,4,5-trihydroxybenzamidoxime), a newly synthesized analog of didox (N,3,4-trihydroxybenzamide) reduced the activity of… Expand
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Highly Cited
2003
Highly Cited
2003
Objective: To determine the role of oxidative stress in mediating HIV dementia and to identify novel therapeutic compounds that… Expand
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2003
2003
PurposeTemozolomide (TMZ), an oral alkylating agent with good penetration of the blood-brain barrier, has shown efficacy in the… Expand
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2001
2001
OBJECTIVE Amidox and didox are two polyhydroxy-substituted benzohydroxamic acid derivatives that belong to a new class of… Expand
1991
1991
Didox and Amidox inhibit L1210 cell growth in culture. At least one of the mechanisms in the mode(s) of action of the compounds… Expand
1988
1988
A phase 1 study of a new ribonucleotide reductase inhibitor, didox, was performed by administration of escalating doses of the… Expand
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