3'-5' exonuclease activity

Known as: 3'-5'-exonuclease activity 
Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end. [GOC:ai]
National Institutes of Health

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5'-3' exonuclease activity

Papers overview

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2007
2007
Uridylate-specific 3' 5'-exoribonucleases involved in uridylate-deletion RNA editing in trypanosomatid mitochondria.
In kinetoplastid protists, maturation of mitochondrial pre-mRNAs involves the insertion and deletion of uridylates (Us) within… (More)
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2006
2006
Chimeric thermostable DNA polymerases with reverse transcriptase and attenuated 3'-5' exonuclease activity.
The synthesis of accurate, full-length cDNA from low-abundance RNA and the subsequent PCR amplification under conditions which… (More)
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2004
2004
The metastasis suppressor NM23-H1 possesses 3'-5' exonuclease activity.
NM23-H1 belongs to a family of eight gene products in humans that have been implicated in cellular differentiation and… (More)
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2002
2002
A minimal exonuclease domain of WRN forms a hexamer on DNA and possesses both 3'- 5' exonuclease and 5'-protruding strand endonuclease activities.
Werner syndrome is a rare autosomal recessive disease characterized by a premature aging phenotype, genomic instability, and a… (More)
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2002
2002
Physical and functional interactions of the tumor suppressor protein p53 and DNA polymerase alpha-primase.
The wild-type form of p53 contains an intrinsic 3'-5'-exonuclease activity. As p53 forms a complex with DNA polymerase alpha… (More)
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2001
2001
Insights into the molecular mechanism of mitochondrial toxicity by AIDS drugs.
Several of the nucleoside analogs used in the treatment of AIDS exhibit a delayed clinical toxicity limiting their usefulness… (More)
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1996
1996
Herpes simplex virus type 1 DNA polymerase. Mutational analysis of the 3'-5'-exonuclease domain.
Like true DNA replicases, herpes simplex virus type 1 DNA polymerase is equipped with a proofreading 3'-5'-exonuclease. In order… (More)
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1991
1991
Overexpression, purification, and characterization of Escherichia coli bacteriophage PRD1 DNA polymerase. In vitro synthesis of full-length PRD1 DNA with purified proteins.
The bacteriophage PRD1 DNA polymerase gene (gene I) has been cloned into the expression vector pPLH101 under the control of the… (More)
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1990
1990
NaF and mononucleotides as inhibitors of 3'-5'-exonuclease activity and stimulators of polymerase activity of E. coli DNA polymerase I Klenow fragment.
It has been shown that, in the absence of dATP in the poly(dT).oligo(dA) template-primer complex, the rate of primer cleavage by… (More)
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1989
1989
[Selective inhibition of 3'-5'-exonuclease activity of DNA-polymerase I from Escherichia coli by a fluoride ion].
The effect of NaF on the enzymatic activities of the large fragment of E. coli DNA polymerase I (Klenow enzyme-KE) with different… (More)
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