• Publications
  • Influence
Evidence for a separate mechanism of toxicity for the Type I and the Type II pyrethroid insecticides.
Overall, based upon neurotoxicity data and the effect of pyrethroids on sodium, calcium and chloride ion channels, it is proposed that bioallethrin, cismethrin, tefluthrin, bifenthrin and permethrin belong to one common mechanism group and deltamethrine, lambda-cyhalothrin, cy Fluthrin and cypermethrin belonging to a second. Expand
Cytoplasmic accumulation of cdc25B phosphatase in mitosis triggers centrosomal microtubule nucleation in HeLa cells.
Data is presented that the cdc25B isoform functions to activate the cytoplasmic pool of cdc2/cyclin B responsible for prophase Mt nucleation and nuclear G2/M events, and suggests that the functional status of the centrosome can regulate nuclear mitotic events. Expand
Insecticidal Activity of Plant Essential Oils Against Pediculus humanus capitis (Anoplura: Pediculidae)
The essential oils described herein merit further study as potential control agents for P. humanus capitis as a result of action in the vapor phase and neither δ-phenothrin nor pyrethrum exhibited fumigant toxicity. Expand
Biochemical and Molecular Analysis of Deltamethrin Resistance in the Common Bed Bug (Hemiptera: Cimicidae)
Evidence suggests that the two mutations identified are likely the major resistance-causing mutations in the deltamethrin-resistant NY-BB through a knockdown-type nerve insensitivity mechanism. Expand
The persistence and degradation of chlorothalonil and chlorpyrifos in a cranberry bog.
The effect of a spray-tank adjuvant on the persistence, distribution, and degradation of two pesticides, chlorothalonil and chlorpyrifos, was studied in a commercial cranberry bog and residue levels were well below the current U.S. EPA tolerances for fresh cranberries. Expand
Insecticide resistance in head lice: clinical, parasitological and genetic aspects.
Clinical, parasitological and molecular data on resistance to conventional topical pediculicides show that treatments with neurotoxic insecticides have suffered considerable loss of activity worldwide, and resistance to synthetic pyrethroids has become prominent, probably because of their extensive use. Expand
Novel non-templated nucleotide addition reactions catalyzed by procaryotic and eucaryotic DNA polymerases.
  • J. Clark
  • Biology, Medicine
  • Nucleic acids research
  • 25 October 1988
Results demonstrate that template instruction is not an absolute requirement for the catalysis of nucleotidyl transfer reactions by DNA polymerases. Expand
Cloning and characterization of a novel human histone deacetylase, HDAC8.
After expression in two cell systems, immunopurified HDAC8 is shown to possess trichostatin A- and sodium butyrate-inhibitable HDAC activity on histone H4 peptide substrates as well as on core histones, confirmingHDAC8 as a new member of the HDAC family. Expand
Resistance to avermectins: extent, mechanisms, and management implications.
Information is gathered on the genetics, biochemical mechanisms, effectiveness of synergists, and cross-resistances to other insecticides from three abamectin-resistant insects that may prove useful in the resistance management of this natural pesticide. Expand
Molecular Analysis of kdr-like Resistance in Permethrin-Resistant Strains of Head Lice, Pediculus capitis
The significantly higher levels of resistance determined using the knockdown ratios compared to the mortality ratios suggest that nerve insensitivity, most likely mediated by mutations within sodium channel genes, is a principal mechanism associated with resistance. Expand