• Publications
  • Influence
A mechanism for initiating RNA-dependent RNA polymerization
TLDR
The results provide a working model for the initiation of replication and transcription of double-stranded RNA viruses and flaviviruses and suggest a mechanism by which the incoming double-Stranded RNA is opened up to feed the template through to the active site, while the substrates enter by another route.
What does structure tell us about virus evolution?
TLDR
Structural analyses of virion architecture and coat protein topology have revealed unexpected similarities, not visible in sequence comparisons, suggesting a common origin for viruses that infect hosts residing in different domains of life (bacteria, archaea and eukarya).
Structure unifies the viral universe.
TLDR
The arguments behind this proposal, the current status of structural work, and the future opportunities for a more concerted effort to provide high-throughput methods to facilitate the large-scale sampling of the virosphere are summarized.
Insights into assembly from structural analysis of bacteriophage PRD1
TLDR
The architectural similarities with adenovirus and one of the largest known virus particles PBCV-1 support the notion that the mechanism of assembly of PRD1 is scaleable and applies across the major viral lineage formed by these viruses.
qiRNA is a new type of small interfering RNA induced by DNA damage
TLDR
The results suggest that QDE-1 is the DNA-dependent RNA polymerase that produces aRNAs, and the Neurospora RNA interference mutants show increased sensitivity to DNA damage, suggesting a role for qiRNAs in theDNA-damage response by inhibiting protein translation.
Viral Evolution Revealed by Bacteriophage PRD1 and Human Adenovirus Coat Protein Structures
TLDR
Although these two dsDNA viruses infect hosts from very different kingdoms, their striking similarities, from major coat protein through capsid architecture, strongly suggest their evolutionary relationship.
Do viruses form lineages across different domains of life?
  • D. Bamford
  • Biology, Medicine
    Research in microbiology
  • 1 May 2003
TLDR
All viruses are old, maybe preceding cellular life, and virus origins are polyphyletic, as opposed to the idea of a monophyletic origin of cellular life.
The Structure of an RNAi Polymerase Links RNA Silencing and Transcription
TLDR
The 2.3-Å resolution crystal structure of QDE-1, a cRdRP from Neurospora crassa, is reported and it is found that it forms a relatively compact dimeric molecule, each subunit with a catalytic apparatus and protein fold strikingly similar to the catalytic core of the DNA-dependent RNA polymerases responsible for transcription.
Structure and host-cell interaction of SH1, a membrane-containing, halophilic euryarchaeal virus
TLDR
The results indicate that SH1 has a complex capsid formed from single β-barrels, an important missing link in hypotheses on viral capsid protein evolution, and unusual, symmetry-mismatched spikes seem to play a role in host adsorption.
An ssDNA virus infecting archaea: a new lineage of viruses with a membrane envelope
TLDR
A new haloarchaeal virus, Halorubrum pleomorphic virus 1 (HRPV‐1) is described that was isolated from a solar saltern and infects an indigenous host belonging to the genus HalorUBrum, and is the first characterized archaealirus that does not have a dsDNA genome.
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