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Nanobiopolymer for Direct Targeting and Inhibition of EGFR Expression in Triple Negative Breast Cancer
TLDR
Treatment of TNBC with a novel nanobioconjugate based on a poly(β-L-malic acid) nanoplatform results in tumor growth arrest by inhibiting EGFR and its downstream signaling intermediate, phosphorylated Akt.
Blood–brain barrier permeable nano immunoconjugates induce local immune responses for glioma therapy
TLDR
This study demonstrates trans-BBB delivery of tumor-targeted polymer-conjugated checkpoint inhibitors as an effective GBM treatment via activation of both systemic and local privileged brain tumor immune response.
Cellular Delivery of Doxorubicin via pH-Controlled Hydrazone Linkage Using Multifunctional Nano Vehicle Based on Poly(β-L-Malic Acid)
TLDR
This work aimed to improve DOX delivery and reduce the toxicity by chemical conjugation with a new nanoplatform based on polymalic acid, found stable under physiological conditions and shown to successfully inhibit in vitro cancer cell growth of several invasive breast carcinoma cell lines.
An unusual polyanion from Physarum polycephalum that inhibits homologous DNA polymerase alpha in vitro.
From extracts of microplasmodia of Physarum polycephalum and their culture medium, an unusual substance was isolated which inhibited homologous DNA polymerase alpha of this slime mold but not
Brain tumor tandem targeting using a combination of monoclonal antibodies attached to biopoly(beta-L-malic acid).
Comparative synthesis and hydrolytic degradation of poly ( L -malate) by myxomycetes and fungi
TLDR
Only 12 of the 237 fungi and myxomycetes showed PMLA-hydrolase activity; and two of these were producers of PMLA, a highly anionic polyester of L-malate.
β-Poly(l-malate) production by Physarum polycephalum
TLDR
Results indicated that l-malate used for PMLA production is synthesized either via carboxylation of pyruvate and reduction of oxaloacetate in the presence of Ca CO3 or via the oxidative tricarboxylic acid (TCA) cycle in the absence of CaCO3.
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