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Acyclic nucleoside phosphonates: a key class of antiviral drugs
The discovery and development of acyclic nucleoside phosphonates is reviewed, focusing on cidofovir and its potential in the treatment of various herpes-, papilloma-, polyoma-, adeno- and pox-virus infections, and the prevention of HIV infections. Expand
Regulation of ribosomal RNA promoters with a synthetic lac operator.
  • J. Brosius, A. Holý
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 1 November 1984
A synthetic 21-base-pair long DNA fragment containing the central lac operator sequence has been inserted near the initiation point of the cloned Escherichia coli rrnB rRNA promoter P2 in the naturalExpand
Antiadenovirus Activities of Several Classes of Nucleoside and Nucleotide Analogues
The antiviral data show that the adenovirus DNA polymerase exhibits sensitivity to a relatively broad spectrum of inhibitors and should be studied further as an antiviral target in antiadenovirus drug development programs. Expand
A novel selective broad-spectrum anti-DNA virus agent
It is reported that, in mice and rabbits in vivo, the compound is effective against both local and systemic infections with herpes simplex virus type 1, including herpetic keratitis caused by a TK− mutant which is resistant to the classical anti-herpes drugs. Expand
Antiviral treatment is more effective than smallpox vaccination upon lethal monkeypox virus infection
Comparing the effectiveness of post-exposure smallpox vaccination and antiviral treatment after lethal intratracheal infection of cynomolgus monkeys with monkeypox virus shows that adequate preparedness for a biological threat involving smallpox should include the possibility of treating exposed individuals with antiviral compounds such as cidofovir or other selective anti-poxvirus drugs. Expand
Antiviral activity of phosphonylmethoxyalkyl derivatives of purine and pyrimidines.
As a rule, the PME derivates were much less inhibitory to VZV, CMV, vaccinia and adenovirus than the HPMP derivatives, however, PMEA, PMEDAP and PMEMAP showed marked and selective activity against the human immunodeficiency virus (HIV). Expand
Differential antiherpesvirus and antiretrovirus effects of the (S) and (R) enantiomers of acyclic nucleoside phosphonates: potent and selective in vitro and in vivo antiretrovirus activities of
(R)-PMPDAP emerged as the most potent and selective inhibitor of MSV-induced transformation of murine C3H/3T3 cells and human immunodeficiency virus-induced cytopathicity in MT-4 and CEM cells and significantly increased the survival time of MSv-infected mice. Expand
Phosphonomethoxyalkyl analogs of nucleotides.
  • A. Holý
  • Biology, Medicine
  • Current pharmaceutical design
  • 30 November 2003
Three compounds of the ANP group are active components of potent antivirals approved for therapeutic use in human medicine aimed at hepatitis B, AIDS and various diseases caused by DNA viruses. Expand
Antiretrovirus Activity of a Novel Class of Acyclic Pyrimidine Nucleoside Phosphonates
Compounds 1 and 11 should be considered attractive novel pyrimidine nucleotide phosphonate analogues to be further pursued for their potential as antiretroviral agents in the clinical setting. Expand
(S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine, a potent and selective inhibitor of human cytomegalovirus replication.
(S)-HPMPC was inhibitory to CMV plaque formation even when added to the cells at 24 or 48 h postinfection, and limited incubation time was insufficient for DHPG to achieve any protection against CMV. Expand