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3',5'-cyclic-nucleotide phosphodiesterase activity

Known as: 3',5' cyclic-nucleotide phosphodiesterase activity, 3': 5'-monophosphate phosphodiesterase (cyclic CMP) activity, nucleoside-3',5-monophosphate phosphodiesterase activity 
Catalysis of the reaction: nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate. [EC:3.1.4.17]
National Institutes of Health

Related topics

Related topics

1 relation
phosphoric diester hydrolase

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2004
2004
Characterization of 3',5' cyclic nucleotide phosphodiesterase activity in Y79 retinoblastoma cells: absence of functional PDE6.
PURPOSE Previous studies identified rod photoreceptor cyclic GMP phosphodiesterase (PDE6) transcripts in the human Y79… 
Highly Cited
2003
Highly Cited
2003
Effect of sildenafil on cyclic nucleotide phosphodiesterase activity, vascular tone and calcium signaling in rat pulmonary artery
Sildenafil (viagra) is a potent PDE5 inhibitor and thus a relaxant drug in corpus carvernosum smooth muscle. In the present work… 
2000
2000
Effect of type‐selective inhibitors on cyclic nucleotide phosphodiesterase activity and insulin secretion in the clonal insulin secreting cell line BRIN‐BD11
The cyclic nucleotide phosphodiesterases (PDEs) present in an insulin secreting cell line, BRIN–BD11, were characterized using… 
1992
1992
Early increase in lymphocyte cyclic nucleotide phosphodiesterase activity upon mitogenic activation of human peripheral blood mononuclear cells
Cyclic nucleotide phosphodiesterase activity of human peripheral blood mononuclear cells was significantly increased following a… 
1985
1985
Correlation between inhibition of a cyclic GMP phosphodiesterase and relaxation of canine tracheal smooth muscle.
1977
1977
Studies on the synergistic effect of androgen on the stimulation of progestin secretion by FSH in cultured rat granulosa cells: A search for the mechanism of action
Review
1976
Review
1976
In vitro inhibition of cyclic AMP phosphodiesterase by cortisol
HORMONAL effects on cyclic nucleotide phosphodiesterase activity are assumed to play an important role in the regulation of… 
1976
1976
Diurnal rhythm in rat pineal cyclic nucleotide phosphodiesterase activity
MANY substances in the rat pineal organ exhibit marked diurnal variations; some of these fluctuations are circadian, that is… 
Highly Cited
1973
Highly Cited
1973
Development of cyclic AMP metabolism in rat liver. A correlative study of tissue levels of cyclic AMP, accumulation of cyclic AMP in slices, adenylate cyclase activity and cyclic nucleotide…
1973
1973
Inhibition of cortical neurones by imidazole and some derivatives.
Systematic tests of imidazole and 15 derivatives, applied by microiontophoresis in anesthetized cats, showed a high inhibitory… 
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