FAQ

3',5'-cyclic-nucleotide phosphodiesterase activity

Known as: 3',5' cyclic-nucleotide phosphodiesterase activity, 3': 5'-monophosphate phosphodiesterase (cyclic CMP) activity, nucleoside-3',5-monophosphate phosphodiesterase activity 
Catalysis of the reaction: nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate. [EC:3.1.4.17]
National Institutes of Health

Topic mentions per year

Topic mentions per year

1969-2018
051019692018

Related topics

Related topics

2 relations
phosphoric diester hydrolaseregulation of cyclic-nucleotide phosphodiesterase activity

Related mentions per year

Related mentions per year

1946-2018
19401960198020002020
3',5'-cyclic-nucleotide phosphodiesterase activity
phosphoric diester hydrolase
regulation of cyclic-nucleotide phosphodiesterase activity

Papers overview

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2005
2005
Zinc-mediated inhibition of cyclic nucleotide phosphodiesterase activity and expression suppresses TNF-alpha and IL-1 beta production in monocytes by elevation of guanosine 3',5'-cyclic monophosphate…
The trace element zinc affects several aspects of immune function, such as the release of proinflammatory cytokines from… (More)
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2005
2005
Age-related alterations in cyclic nucleotide phosphodiesterase activity in dystrophic mouse leg muscle.
Previous reports have described both increased and decreased cyclic nucleotide phosphodiesterase (PDE) activity in dystrophic… (More)
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2004
2004
Characterization of 3',5' cyclic nucleotide phosphodiesterase activity in Y79 retinoblastoma cells: absence of functional PDE6.
PURPOSE Previous studies identified rod photoreceptor cyclic GMP phosphodiesterase (PDE6) transcripts in the human Y79… (More)
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Highly Cited
2004
Highly Cited
2004
Prune cAMP phosphodiesterase binds nm23-H1 and promotes cancer metastasis.
We identify a new enzymatic activity underlying metastasis in breast cancer and describe its susceptibility to therapeutic… (More)
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2003
2003
Effect of sildenafil on cyclic nucleotide phosphodiesterase activity, vascular tone and calcium signaling in rat pulmonary artery.
(1) Sildenafil (viagra) is a potent PDE5 inhibitor and thus a relaxant drug in corpus carvernosum smooth muscle. In the present… (More)
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2000
2000
Effect of type-selective inhibitors on cyclic nucleotide phosphodiesterase activity and insulin secretion in the clonal insulin secreting cell line BRIN-BD11.
1. The cyclic nucleotide phosphodiesterases (PDEs) present in an insulin secreting cell line, BRIN - BD11, were characterized… (More)
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Highly Cited
1991
Highly Cited
1991
Cyclic nucleotides differentially regulate the synthesis of tumour necrosis factor-alpha and interleukin-1 beta by human mononuclear cells.
Recent reports have shown that phosphodiesterase (PDE) inhibitors suppress production of tumour necrosis factor-alpha (TNF-alpha… (More)
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1991
1991
Inhibitory effect of calcium-binding protein regucalcin on Ca2+/calmodulin-dependent cyclic nucleotide phosphodiesterase activity in rat liver cytosol
The effect of regucalcin, a calcium-binding protein isolated from rat liver cytosol, on Ca2+/calmodulin-dependent cyclic… (More)
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1980
1980
Effect of phorbol ester application and other mitogenic treatments on 3',5'-cyclic-nucleotide phosphodiesterase activity in mouse epidermis in vivo.
The effects of phorbol ester application and of other mitogenic treatments on the activity of 3',5'-cyclic-nucleotide… (More)
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1971
1971
Cyclic 3',5'-nucleotide phosphodiesterase: cytochemical localization in cerebral cortex.
The distribution of cyclic 3',5'-nucleotide phosphodiesterase activity in rat cerebral cortex was determined by cytochemical… (More)
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