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The effects of traditional antidiabetic plants on in vitro glucose diffusion
TLDR
The results suggest that part of the antihyperglycemic actions of these plants may be by decreasing glucose absorption in vivo. Expand
Evaluation of the insulin releasing and antihyperglycaemic activities of GPR55 lipid agonists using clonal beta‐cells, isolated pancreatic islets and mice
TLDR
The effects of various GPR55 agonists on glucose homeostasis are assessed using a novel lipid sensing receptor activated by both cannabinoid endogenous ligands (endocannabinoids) and other non‐cannabinoid lipid transmitters. Expand
Vitamin C supplementation decreases insulin glycation and improves glucose homeostasis in obese hyperglycemic (ob/ob) mice.
TLDR
It is demonstrated that vitamin C supplementation can decrease insulin glycation and ameliorate aspects of the obesity-diabetes syndrome in ob/ob mice. Expand
Effect of type‐selective inhibitors on cyclic nucleotide phosphodiesterase activity and insulin secretion in the clonal insulin secreting cell line BRIN‐BD11
TLDR
These findings, in a clonal insulin secreting cell line, are consistent with an important role for PDE3B in regulating the pool of cyclic AMP relevant to the modulation of glucose‐induced insulin secretion. Expand
A glycine-leucine-rich peptide structurally related to the plasticins from skin secretions of the frog Leptodactylus laticeps (Leptodactylidae)
TLDR
A glycine-leucine-rich peptide was isolated from norepinephrine-stimulated skin secretions of the Sante Fe frog Leptodactylus laticeps whose primary structure contains the (GXXXG)(3) motif found in the plasticins, previously identified only in phyllomedusid frogs (Hylidae). Expand
Caerulein precursor fragment (CPF) peptides from the skin secretions of Xenopus laevis and Silurana epitropicalis are potent insulin-releasing agents.
TLDR
Ten peptides with the ability to stimulate the release of insulin from the rat BRIN-BD11 clonal β cell line are identified and show potential for development into agents for the treatment of Type 2 diabetes. Expand
Activation of GPR119 by fatty acid agonists augments insulin release from clonal β-cells and isolated pancreatic islets and improves glucose tolerance in mice.
TLDR
The cellular localisation of GPR119 on islet cells (β and pancreatic polypeptide cells), its activation of the β-cell stimulus-secretion coupling pathway and glucose lowering effects in vivo are demonstrated. Expand
In vitro and in vivo insulinotropic properties of the multifunctional frog skin peptide hymenochirin-1B: a structure–activity study
TLDR
Intraperitoneal administration of the [P5K] and [D9k] analogues to high-fat-fed mice with insulin resistance significantly enhanced glucose tolerance with a concomitant increase in insulin secretion and it is concluded that Hym-1B and D9k show potential for development into anti-diabetic agents. Expand
Metabolic effects of orally administered small-molecule agonists of GPR55 and GPR119 in multiple low-dose streptozotocin-induced diabetic and incretin-receptor-knockout mice
TLDR
These data highlight the potential for fatty acid G-protein-coupled receptor-based therapies as novel insulinotropic and glucose-lowering agents acting partly through the activation of incretin receptors and the actions and ability of small-molecule agonists to counteract experimental diabetes in mice. Expand
Terminalia bellirica stimulates the secretion and action of insulin and inhibits starch digestion and protein glycation in vitro.
TLDR
Investigation of the efficacy and mode of action of Terminalia bellirica used traditionally for the treatment of diabetes in India revealed that components in T. Bellirica extract stimulate insulin secretion, enhance insulin action and inhibit both protein glycation and starch digestion. Expand
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