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The anticonvulsant MK-801 is a potent N-methyl-D-aspartate antagonist.
TLDR
Neurophysiological studies in vitro, using a rat cortical-slice preparation, demonstrated a potent, selective, and noncompetitive antagonistic action of MK-801 on depolarizing responses to N-Me-D-Asp but not to kainate or quisqualate, providing an explanation for the mechanism of action ofMK-801 as an anticonvulsant. Expand
REGIONAL STUDIES OF CATECHOLAMINES IN THE RAT BRAIN‐I
TLDR
It is revealed that norepinephrine and dopamine are specifically localized in complex systems of neurons in the brain, a finding which lends support to the hypothesis that both amines may be neurotransmitters in the central nervous system. Expand
Cannabis and the brain.
  • L. Iversen
  • Psychology, Medicine
  • Brain : a journal of neurology
  • 1 June 2003
TLDR
Central effects of cannabinoids include disruption of psychomotor behaviour, short-term memory impairment, intoxication, stimulation of appetite, antinociceptive actions (particularly against pain of neuropathic origin) and anti-emetic effects. Expand
7-Chlorokynurenic acid is a selective antagonist at the glycine modulatory site of the N-methyl-D-aspartate receptor complex.
TLDR
Findings indicate that the glycine modulatory site is functional in intact adult tissue and that 7-Cl KYNA should prove to be a selective tool for elucidating the involvement of this site in physiological and pathological events mediated by N-Me-D-Asp receptors. Expand
REGIONAL STUDIES OF CATECHOLAMINES IN THE RAT BRAIN–II
TLDR
The development of techniques for the administration of radioactive norepinephrine into the lateral ventricle of the rat brain allows a direct labelling of the brain catecholamines by exposure to radioactive norpinephrine by measuring the rate of decline of specific activity of the amines after the introduction of small amounts of radioactively labelled catechlamines into the endogenous pools. Expand
Uptake Processes for Biogenic Amines
In recent years, it has become apparent that neurons have associated with them specific transport systems for the particular transmitter which they manufacture and release. Thus neurons that releaseExpand
Dopamine: 50 years in perspective
TLDR
Dopamine research has had a greater impact on the development of biological psychiatry and psychopharmacology than work on any other neurotransmitter. Expand
Neuropeptides: Regulators of Physiological Processes by Fleur L. Strand, MIT Press, 1999. £45.00, $65.00 (xi + 658 pages) ISBN 0 262 19407 4
  • L. Iversen
  • Biology
  • Trends in Neurosciences
  • 1 October 1999
TLDR
The author provides an easily understood review of the many different experimental approaches needed to study the genes, receptors, distribution, biosynthesis, release and actions of the neuropeptides, and this monograph provides a valuable overview of the evolution and biological importance of peptides as chemical signalling molecules. Expand
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