The anticonvulsant MK-801 is a potent N-methyl-D-aspartate antagonist.
- E. Wong, J. Kemp, T. Priestley, A. R. Knight, G. Woodruff, L. Iversen
- Biology, ChemistryProceedings of the National Academy of Sciences…
- 1 September 1986
Neurophysiological studies in vitro, using a rat cortical-slice preparation, demonstrated a potent, selective, and noncompetitive antagonistic action of MK-801 on depolarizing responses to N-Me-D-Asp but not to kainate or quisqualate, providing an explanation for the mechanism of action ofMK-801 as an anticonvulsant.
REGIONAL STUDIES OF CATECHOLAMINES IN THE RAT BRAIN‐I
- J. Glowinski, L. Iversen
- Biology, ChemistryJournal of Neurochemistry
- 1 August 1966
It is revealed that norepinephrine and dopamine are specifically localized in complex systems of neurons in the brain, a finding which lends support to the hypothesis that both amines may be neurotransmitters in the central nervous system.
Cannabis and the brain.
- L. Iversen
- Biology, PsychologyBrain : a journal of neurology
- 1 June 2003
Central effects of cannabinoids include disruption of psychomotor behaviour, short-term memory impairment, intoxication, stimulation of appetite, antinociceptive actions (particularly against pain of neuropathic origin) and anti-emetic effects.
The Uptake and Storage of Noradrenaline in Sympathetic Nerves
- L. Iversen
- Biology
- 2 January 1967
Dopamine: 50 years in perspective
- S. Iversen, L. Iversen
- Psychology, MedicineTrends in Neurosciences
- 1 May 2007
7-Chlorokynurenic acid is a selective antagonist at the glycine modulatory site of the N-methyl-D-aspartate receptor complex.
- J. Kemp, A. Foster, G. Woodruff
- Biology, ChemistryProceedings of the National Academy of Sciences…
- 1 September 1988
Findings indicate that the glycine modulatory site is functional in intact adult tissue and that 7-Cl KYNA should prove to be a selective tool for elucidating the involvement of this site in physiological and pathological events mediated by N-Me-D-Asp receptors.
Uptake and metabolism of γ-aminobutyric acid by neurones and glial cells
- L. Iversen, J. Kelly
- Biology
- 1 May 1975
Multiple opiate receptor sites on primary afferent fibres
- H. Fields, P. Emson, B. K. Leigh, R. Gilbert, L. Iversen
- BiologyNature
- 27 March 1980
In addition to their actions at supraspinal sites, opiates can act directly at the spinal cord level to produce analgesia1–3. Opiate receptors and enkephalins are found in abundance in the dorsal…
Neurotransmitter transporters and their impact on the development of psychopharmacology
- L. Iversen
- BiologyBritish Journal of Pharmacology
- 1 January 2006
The amino‐acid neurotransmitters are inactivated by other families of neurotransmitter transporters, mainly located on astrocytes and other non‐neural cells, and pharmacology is less well developed in this area.
Substance P.
- B. Sandberg, L. Iversen
- Computer ScienceJournal of Medicinal Chemistry
- 1982
This document discusses solubility, usage and handling of the Synthetic Product, which describes how to prepare and use solutions on the same day to make up stock solutions.
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