14-alpha Demethylase Inhibitors

Known as: Lanosterol 14 alpha-Demethylase Inhibitors, Inhibitors, 14alpha-Demethylase, Inhibitors, 14-alpha Demethylase 
Compounds that specifically inhibit STEROL 14-DEMETHYLASE. A variety of azole-derived ANTIFUNGAL AGENTS act through this mechanism.
National Institutes of Health

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Papers overview

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Review
2014
Review
2014
The H3K27me3 demethylase UTX in normal development and disease
In 2007, the Ubiquitously Transcribed Tetratricopeptide Repeat on chromosome X (UTX) was identified as a histone demethylase that… (More)
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2014
2014
Reversible LSD1 inhibition interferes with global EWS/ETS transcriptional activity and impedes Ewing sarcoma tumor growth.
PURPOSE Ewing sarcoma is a pediatric bone tumor that absolutely relies on the transcriptional activity of the EWS/ETS family of… (More)
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2014
2014
Histone demethylase KDM2A promotes tumor cell growth and migration in gastric cancer
Histone demethylase KDM2A has been reported to be dysregulated in lung cancer. However, its function in gastric cancer remains… (More)
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2010
2010
Second generation analogues of the cancer drug clinical candidate tipifarnib for anti-Chagas disease drug discovery.
We previously reported that the cancer drug clinical candidate tipifarnib kills the causative agent of Chagas disease… (More)
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1997
1997
Competitive interactions between cytochromes P450 2A6 and 2E1 for NADPH-cytochrome P450 oxidoreductase in the microsomal membranes produced by a baculovirus expression system.
The present study investigated the interactions between cytochrome P450 (P450) enzymes and the NADPH:cytochrome oxidoreductase… (More)
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1994
1994
Selective inhibition of mammalian lanosterol 14 alpha-demethylase by RS-21607 in vitro and in vivo.
The discovery of selective lanosterol 14 alpha-demethylase inhibitors may lead to novel hypolipidemic drugs. RS-21607, (2S,4S… (More)
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1990
1990
Rapid decrease of cytochrome P-450IIE1 in primary hepatocyte culture and its maintenance by added 4-methylpyrazole.
Studies were conducted to evaluate the possible induction or the maintenance of cytochrome P-450IIE1 in primary hepatocyte… (More)
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1983
1983
Alterations of microsomal monooxygenase system and carcinogen metabolism by streptozotocin-induced diabetes in rats.
The effects of diabetes on the liver microsomal monooxygenase enzymes and carcinogen metabolism have been studied in rats… (More)
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1975
1975
Induction and suppression of hepatic and extrahepatic microsomal foreign-compound-metabolizing enzyme systems by 2,3,7,8-tetrachlorodibenzo-p-dioxin.
The effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on a number of hepatic and extrahepatic foreign-compound-metabolizing… (More)
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1970
1970
Mechanism of 3-methylcholanthrene-induced inhibition of dimethylnitrosamine demethylase in rat liver.
 
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