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14-alpha Demethylase Inhibitors

Known as: Lanosterol 14 alpha-Demethylase Inhibitors, Inhibitors, 14alpha-Demethylase, Inhibitors, 14-alpha Demethylase 
Compounds that specifically inhibit STEROL 14-DEMETHYLASE. A variety of azole-derived ANTIFUNGAL AGENTS act through this mechanism.
National Institutes of Health

Papers overview

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2015
2015
Abstract 1. Precision-cut liver slices are one of the in vitro models used in studies concerning xenobiotic metabolism. Sparse… 
2005
2005
This study examined the role of Kupffer cells in altering the hepatic secretory and microsomal function during ischemia and… 
1997
1997
To determine whether carotenoids can modulate xenobiotic-metabolizing enzymes in mice, catalytic activities of several phase I… 
1994
1994
The discovery of selective lanosterol 14 alpha-demethylase inhibitors may lead to novel hypolipidemic drugs. RS-21607, (2S,4S… 
1986
1986
The effect of polyriboinosinic acid-polyribocytidylic acid [poly(I).poly(C)] on glucuronyltransferase activities toward 4… 
Highly Cited
1973
Highly Cited
1973
  • H. Vainio
  • 1973
  • Corpus ID: 31880922
Abstract1. The rise in p-nitroanisole O-demethylase activity in liver microsomes after phenobarbital treatment of rats slightly… 
1970
1970
Starvation of rats for 24 hr considerably enhances hepatic dimethylnitrosamine demethylase activity, and 3-methylcholanthrene…