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14-alpha Demethylase Inhibitors

Known as: Lanosterol 14 alpha-Demethylase Inhibitors, Inhibitors, 14alpha-Demethylase, Inhibitors, 14-alpha Demethylase 
Compounds that specifically inhibit STEROL 14-DEMETHYLASE. A variety of azole-derived ANTIFUNGAL AGENTS act through this mechanism.
National Institutes of Health

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ClotrimazoleEconazoleFluconazoleItraconazole
In Bloodaspects of radiation effectschemical synthesisstandards characteristics

Papers overview

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2015
2015
Gene expression and enzyme function of two cytochrome P450 3A isoenzymes in rat and cattle precision cut liver slices
Abstract 1. Precision-cut liver slices are one of the in vitro models used in studies concerning xenobiotic metabolism. Sparse… 
2005
2005
The roles of kupffer cells in hepatic dysfunction induced by ischemia/reperfusion in rats
This study examined the role of Kupffer cells in altering the hepatic secretory and microsomal function during ischemia and… 
1998
1998
Effects of a vegetables-fruit mixture on liver and colonic 1,2-dimethylhydrazine-metabolizing enzyme activities in rats fed low- or high-fat diets.
1997
1997
Effects of provitamin A or non-provitamin A carotenoids on liver xenobiotic-metabolizing enzymes in mice.
To determine whether carotenoids can modulate xenobiotic-metabolizing enzymes in mice, catalytic activities of several phase I… 
1994
1994
Selective inhibition of mammalian lanosterol 14 alpha-demethylase by RS-21607 in vitro and in vivo.
The discovery of selective lanosterol 14 alpha-demethylase inhibitors may lead to novel hypolipidemic drugs. RS-21607, (2S,4S… 
1987
1987
In vivo protection by protein A of hepatic microsomal mixed function oxidase system of CCl4-administered rats.
1986
1986
Suppressive effect of interferon inducer, polyriboinosinic acid-polyribocytidylic acid on induction of uridine diphosphate-glucuronyltransferases and monooxygenases in liver microsomes of rats.
The effect of polyriboinosinic acid-polyribocytidylic acid [poly(I).poly(C)] on glucuronyltransferase activities toward 4… 
1976
1976
Enhancement of microsomal monooxygenase, epoxide hydrase and UDPglucuronyltransferase by aldrin, dieldrin and isosafrole administrations in rat liver.
Highly Cited
1973
Highly Cited
1973
Drug hydroxylation and glucuronidation in liver microsomes of phenobarbital-treated rats.
  • H. Vainio
  • Xenobiotica; the fate of foreign compounds in…
  • 1973
  • Corpus ID: 31880922
Abstract1. The rise in p-nitroanisole O-demethylase activity in liver microsomes after phenobarbital treatment of rats slightly… 
1970
1970
Amino acid induction and carbohydrate repression of dimethylnitrosamine demethylase in rat liver.
Starvation of rats for 24 hr considerably enhances hepatic dimethylnitrosamine demethylase activity, and 3-methylcholanthrene… 
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