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Itraconazole

Known as: Itraconazol, (+-)-1-sec-Butyl-4-(p-(4-(p-(((2R*,4S*)-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl)methoxy)phenyl)-1-piperazinyl)phenyl)-delta(sup 2)-1,2,4-triazolin-5-one, Itraconazole [Chemical/Ingredient] 
A synthetic triazole agent with antimycotic properties. Formulated for both topical and systemic use, itraconazole preferentially inhibits fungal… Expand
National Institutes of Health

Papers overview

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Review
2018
Review
2018
The Hedgehog (Hh) signaling pathway was first identified in the common fruit fly. It is a highly conserved evolutionary pathway… Expand
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Highly Cited
2010
Highly Cited
2010
In a screen of drugs previously tested in humans we identified itraconazole, a systemic antifungal, as a potent antagonist of the… Expand
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Highly Cited
2008
Highly Cited
2007
Highly Cited
2007
BACKGROUND Patients with neutropenia resulting from chemotherapy for acute myelogenous leukemia or the myelodysplastic syndrome… Expand
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Highly Cited
2004
Highly Cited
2004
Prophylactic fluconazole prevents candidiasis; however, this drug has no activity against molds. We performed a randomized trial… Expand
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Highly Cited
2003
Highly Cited
2003
BACKGROUND Chronic granulomatous disease is a rare disorder in which the phagocytes fail to produce hydrogen peroxide. The… Expand
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Highly Cited
2000
Highly Cited
2000
BACKGROUND Allergic bronchopulmonary aspergillosis is a hypersensitivity disorder that can progress from an acute phase to… Expand
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Highly Cited
1998
Highly Cited
1998
BACKGROUND Itraconazole increases the risk of skeletal muscle toxicity of some 3-hydroxy-3-methylglutaryl coenzyme A' (HMG-CoA… Expand
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Highly Cited
1997
Highly Cited
1997
Invasive aspergillosis is an increasingly frequent opportunistic infection in immunocompromised patients. Only two agents… Expand
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Highly Cited
1991
Highly Cited
1991
s of student project reports: Kenya courses since 1995 Page 1 of 4 Student projects carried out on TBA courses in Kenya are… Expand
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