Itraconazole

Known as: Itraconazol, (+-)-1-sec-Butyl-4-(p-(4-(p-(((2R*,4S*)-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl)methoxy)phenyl)-1-piperazinyl)phenyl)-delta(sup 2)-1,2,4-triazolin-5-one, Itraconazole [Chemical/Ingredient] 
A synthetic triazole agent with antimycotic properties. Formulated for both topical and systemic use, itraconazole preferentially inhibits fungal… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1945-2018
020040019452017

Papers overview

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Highly Cited
2010
Highly Cited
2010
In a screen of drugs previously tested in humans we identified itraconazole, a systemic antifungal, as a potent antagonist of the… (More)
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Highly Cited
2007
Highly Cited
2007
BACKGROUND Patients with neutropenia resulting from chemotherapy for acute myelogenous leukemia or the myelodysplastic syndrome… (More)
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Highly Cited
2006
Highly Cited
2006
The in vitro activity of the novel triazole antifungal agent posaconazole (Noxafil; SCH 56592) was assessed in 45 laboratories… (More)
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Highly Cited
2004
Highly Cited
2004
Prophylactic fluconazole prevents candidiasis; however, this drug has no activity against molds. We performed a randomized trial… (More)
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Highly Cited
2004
Highly Cited
2004
Itraconazole (ITZ) is a potent inhibitor of CYP3A in vivo. However, unbound plasma concentrations of ITZ are much lower than its… (More)
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Highly Cited
2003
Highly Cited
2003
We examined the in vitro activity of caspofungin, posaconazole, voriconazole, ravuconazole, itraconazole, and amphotericin B… (More)
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Highly Cited
2003
Highly Cited
2003
BACKGROUND Allogeneic hematopoietic stem-cell transplant recipients often receive fluconazole or an amphotericin B preparation… (More)
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Highly Cited
1997
Highly Cited
1997
Invasive aspergillosis is an increasingly frequent opportunistic infection in immunocompromised patients. Only two agents… (More)
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Highly Cited
1994
Highly Cited
1994
Interaction between ketoconazole, itraconazole, and midazolam was investigated in a double-blind, randomized crossover study of… (More)
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Highly Cited
1989
Highly Cited
1989
PURPOSE Invasive aspergillosis in the immunocompromised host is one of the most difficult therapeutic problems. Itraconazole, a… (More)
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