G. Alink

Publications192
h-index38
Citations4,822
Highly Influential Citations135
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Tissue distribution of quercetin in rats and pigs.
Quercetin is a dietary polyphenolic compound with potentially beneficial effects on health. Claims that quercetin has biological effects are based mainly on in vitro studies with quercetin aglycone.… Expand
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Flavonoids and alkenylbenzenes: mechanisms of mutagenic action and carcinogenic risk.
The present review focuses on the mechanisms of mutagenic action and the carcinogenic risk of two categories of botanical ingredients, namely the flavonoids with quercetin as an important bioactive… Expand
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The pro-oxidant chemistry of the natural antioxidants vitamin C, vitamin E, carotenoids and flavonoids.
Natural antioxidants like vitamin C, vitamin E, carotenoids, and polyphenols like flavonoids, are at present generally considered to be beneficial components from fruit and vegetables. The… Expand
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HEALTH EFFECTS AND TIME COURSE OF PARTICULATE MATTER ON THE CARDIOPULMONARY SYSTEM IN RATS WITH LUNG INFLAMMATION
Recent epidemiological studies associate health effects and particulate matter in ambient air. Exacerbation of the particle-induced inflammation can be a mechanism responsible for increased… Expand
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Safety evaluation of neem (Azadirachta indica) derived pesticides.
The neem tree, Azadirachta indica, provides many useful compounds that are used as pesticides and could be applied to protect stored seeds against insects. However in addition to possible beneficial… Expand
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The role of cyclooxygenase in n-6 and n-3 polyunsaturated fatty acid mediated effects on cell proliferation, PGE(2) synthesis and cytotoxicity in human colorectal carcinoma cell lines.
This study was conducted to investigate the role of the enzyme cyclooxygenase (COX) and its prostaglandin product PGE(2) in n-6 and n-3 polyunsaturated fatty acid (PUFA)-mediated effects on cellular… Expand
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Role of surface charge and oxidative stress in cytotoxicity of organic monolayer-coated silicon nanoparticles towards macrophage NR8383 cells
BackgroundSurface charge and oxidative stress are often hypothesized to be important factors in cytotoxicity of nanoparticles. However, the role of these factors is not well understood. Hence, the… Expand
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A critical assessment of some biomarker approaches linked with dietary intake
In this review many examples are given of the complexities involved in using some biomarkers in relation to assessing the effects of dietary exposure, when there is frequently a need to determine… Expand
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Molecular mechanisms of toxicity of important food-borne phytotoxins.
At present, there is an increasing interest for plant ingredients and their use in drugs, for teas, or in food supplements. The present review describes the nature and mechanism of action of the… Expand
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Surface charge-specific cytotoxicity and cellular uptake of tri-block copolymer nanoparticles
Abstract A series of monodisperse (45 ± 5 nm) fluorescent nanoparticles from tri-block copolymers (polymeric nanoparticles (PNPs)) bearing different surface charges were synthesised and investigated… Expand
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