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1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase

Known as: Phospholipase C, Phosphatidylinositide-4,5-Bisphosphate, 1 Phosphatidylinositol 4,5 Bisphosphate Phosphodiesterase, Phosphoinositide Phospholipase C [Chemical/Ingredient] 
A type C phospholipase with specificity towards PHOSPHATIDYLINOSITOLS that contain INOSITOL 1,4,5-TRISPHOSPHATE. Many of the enzymes listed under… 
National Institutes of Health

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14 relations
1-Phosphatidylinositol phosphodiesteraseIn BloodPLCB3 protein, humanPLCE1 gene

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PLCH2 protein, humanphospholipase C epsilon

Papers overview

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Highly Cited
2007
Highly Cited
2007
Binding of Ras to Phosphoinositide 3-Kinase p110α Is Required for Ras- Driven Tumorigenesis in Mice
Review
2004
Review
2004
Phosphoinositide 3-kinase: diverse roles in immune cell activation.
Cells of the immune system carry out diverse functions that are controlled by surface receptors for antigen, costimulatory… 
Highly Cited
2004
Highly Cited
2004
Endothelin-1 promotes myofibroblast induction through the ETA receptor via a rac/phosphoinositide 3-kinase/Akt-dependent pathway and is essential for the enhanced contractile phenotype of fibrotic…
The endothelins are a family of endothelium-derived peptides that possess a variety of functions, including vasoconstriction… 
Highly Cited
2003
Highly Cited
2003
Long-Term Treatment With Oral Sildenafil Is Safe and Improves Functional Capacity and Hemodynamics in Patients With Pulmonary Arterial Hypertension
Background—The prognosis and functional capacity of patients with pulmonary arterial hypertension (PAH) is poor, and there is a… 
Review
1999
Review
1999
Signalling through phosphoinositide 3-kinases: the lipids take centre stage.
Highly Cited
1994
Highly Cited
1994
Activation of phosphoinositide 3-kinase is required for PDGF-stimulated membrane ruffling
Highly Cited
1990
Highly Cited
1990
Purification and characterization of phosphoinositide 3-kinase from rat liver.
Highly Cited
1985
Highly Cited
1985
Role of guanine nucleotide binding protein in the activation of polyphosphoinositide phosphodiesterase
Interaction of ligands with ‘Ca2+-mobilizing’ receptors is thought to result in the generation of two second messengers, inositol… 
Highly Cited
1983
Highly Cited
1983
Rapid breakdown of phosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate in rat hepatocytes stimulated by vasopressin and other Ca2+-mobilizing hormones.
Rat hepatocytes rapidly incorporate [32P]Pi into phosphatidylinositol 4-phosphate (PtdIns4P) and phosphatidylinositol 4,5… 
Highly Cited
1981
Highly Cited
1981
The polyphosphoinositide phosphodiesterase of erythrocyte membranes.
1. A new assay procedure has been devised for measurement of the Ca(2+)-activated polyphosphoinositide phosphodiesterase… 
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