Endothelin-1 promotes myofibroblast induction through the ETA receptor via a rac/phosphoinositide 3-kinase/Akt-dependent pathway and is essential for the enhanced contractile phenotype of fibrotic fibroblasts.

@article{Shiwen2004Endothelin1PM,
  title={Endothelin-1 promotes myofibroblast induction through the ETA receptor via a rac/phosphoinositide 3-kinase/Akt-dependent pathway and is essential for the enhanced contractile phenotype of fibrotic fibroblasts.},
  author={Xu Shi-wen and Yunliang Chen and Christopher P. Denton and Mark Eastwood and Elisabetta A Renzoni and George Bou-Gharios and Jeremy D. Pearson and Michael Richard Dashwood and Roland M du Bois and Carol Mary Black and Andrew Leask and David J. Abraham},
  journal={Molecular biology of the cell},
  year={2004},
  volume={15 6},
  pages={
          2707-19
        }
}
The endothelins are a family of endothelium-derived peptides that possess a variety of functions, including vasoconstriction. Endothelin-1 (ET-1) is up-regulated during tissue repair and promotes myofibroblast contraction and migration, hence contributing to matrix remodeling during tissue repair. Here, we show that addition of ET-1 to normal lung fibroblasts induces expression of proteins that contribute to a contractile phenotype, including alpha-smooth muscle actin (alpha-SMA), ezrin, moesin… CONTINUE READING