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- Publications
- Influence
TGF‐β signaling and the fibrotic response
- A. Leask, D. Abraham
- Medicine, Biology
- FASEB journal : official publication of the…
- 1 May 2004
The cause of fibrotic diseases, pathologies characterized by excessive production, deposition, and contraction of extracellular matrix, is unknown. To understand the molecular basis of fibrotic… Expand
Clearing algorithms for barter exchange markets: enabling nationwide kidney exchanges
- D. Abraham, A. Blum, T. Sandholm
- Computer Science
- EC '07
- 11 June 2007
In barter-exchange markets, agents seek to swap their items with one another, in order to improve their own utilities. These swaps consist of cycles of agents, with each agent receiving the item of… Expand
All in the CCN family: essential matricellular signaling modulators emerge from the bunker
- A. Leask, D. Abraham
- Biology, Medicine
- Journal of Cell Science
- 1 December 2006
The CCN family is a group of six secreted proteins that specifically associate with the extracellular matrix. Structurally, CCN proteins are modular, containing up to four distinct functional… Expand
Popular matchings
- D. Abraham, R. Irving, T. Kavitha, K. Mehlhorn
- Mathematics, Computer Science
- SODA '05
- 23 January 2005
TLDR
CCN2 is required for bleomycin-induced skin fibrosis in mice.
- S. Liu, X. Shi-wen, D. Abraham, A. Leask
- Biology, Medicine
- Arthritis and rheumatism
- 2011
OBJECTIVE
No therapy for fibrotic disease is available. The proadhesive matricellular protein connective tissue growth factor CCN2 is a marker of fibrotic cells; however, the specific role of CCN2 in… Expand
CTGF and SMADs, Maintenance of Scleroderma Phenotype Is Independent of SMAD Signaling*
- A. Holmes, D. Abraham, S. Sa, X. Shi-wen, C. Black, A. Leask
- Chemistry, Medicine
- The Journal of Biological Chemistry
- 6 April 2001
In normal adult fibroblasts, transforming growth factor-β (TGFβ) induces the expression of connective tissue growth factor (CTGF). CTGF independently promotes fibroblast proliferation and matrix… Expand
Endothelin-1 promotes myofibroblast induction through the ETA receptor via a rac/phosphoinositide 3-kinase/Akt-dependent pathway and is essential for the enhanced contractile phenotype of fibrotic…
- X. Shi-wen, Y. Chen, +9 authors D. Abraham
- Biology, Medicine
- Molecular biology of the cell
- 1 June 2004
The endothelins are a family of endothelium-derived peptides that possess a variety of functions, including vasoconstriction. Endothelin-1 (ET-1) is up-regulated during tissue repair and promotes… Expand
CTGF expression in mesangial cells: involvement of SMADs, MAP kinase, and PKC.
- Y. Chen, I. Blom, S. Sa, R. Goldschmeding, D. Abraham, A. Leask
- Biology, Medicine
- Kidney international
- 1 October 2002
BACKGROUND
The induction of excess matrix in renal fibrosis seems to be mediated, at least in part, by the transforming growth factor-beta (TGF-beta)-mediated induction of connective tissue growth… Expand
Endothelial to Mesenchymal Transition Contributes to Endothelial Dysfunction in Pulmonary Arterial Hypertension.
- R. Good, A. Gilbane, +4 authors Alan M. Holmes
- Medicine
- The American journal of pathology
- 1 July 2015
Pulmonary arterial hypertension (PAH) is a progressive disease characterized by lung endothelial cell dysfunction and vascular remodeling. Normally, the endothelium forms an integral cellular barrier… Expand
The role of connective tissue growth factor, a multifunctional matricellular protein, in fibroblast biology.
- A. Leask, D. Abraham
- Biology, Medicine
- Biochemistry and cell biology = Biochimie et…
- 1 November 2003
Connective tissue growth factor (CTGF, CCN2), a member of the CCN family of proteins, is a cysteine-rich proadhesive matricellular protein that plays an essential role in the formation of blood… Expand