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TGF‐β signaling and the fibrotic response
The cause of fibrotic diseases, pathologies characterized by excessive production, deposition, and contraction of extracellular matrix, is unknown. To understand the molecular basis of fibrotic… Expand
Clearing algorithms for barter exchange markets: enabling nationwide kidney exchanges
In barter-exchange markets, agents seek to swap their items with one another, in order to improve their own utilities. These swaps consist of cycles of agents, with each agent receiving the item of… Expand
All in the CCN family: essential matricellular signaling modulators emerge from the bunker
The CCN family is a group of six secreted proteins that specifically associate with the extracellular matrix. Structurally, CCN proteins are modular, containing up to four distinct functional… Expand
In this paper, we give the first polynomial-time algorithms to determine if an instance admits a popular matching, and to find a largest such matching, if one exists, and show that the problem has equivalent time complexity to the maximum-cardinality bipartite matching problem. Expand
CCN2 is required for bleomycin-induced skin fibrosis in mice.
OBJECTIVE No therapy for fibrotic disease is available. The proadhesive matricellular protein connective tissue growth factor CCN2 is a marker of fibrotic cells; however, the specific role of CCN2 in… Expand
CTGF and SMADs, Maintenance of Scleroderma Phenotype Is Independent of SMAD Signaling*
- A. Holmes, D. Abraham, S. Sa, X. Shi-wen, C. Black, A. Leask
- Chemistry, Medicine
- The Journal of Biological Chemistry
- 6 April 2001
In normal adult fibroblasts, transforming growth factor-β (TGFβ) induces the expression of connective tissue growth factor (CTGF). CTGF independently promotes fibroblast proliferation and matrix… Expand
Endothelin-1 promotes myofibroblast induction through the ETA receptor via a rac/phosphoinositide 3-kinase/Akt-dependent pathway and is essential for the enhanced contractile phenotype of fibrotic…
The endothelins are a family of endothelium-derived peptides that possess a variety of functions, including vasoconstriction. Endothelin-1 (ET-1) is up-regulated during tissue repair and promotes… Expand
CTGF expression in mesangial cells: involvement of SMADs, MAP kinase, and PKC.
- Y. Chen, I. Blom, S. Sa, R. Goldschmeding, D. Abraham, A. Leask
- Biology, Medicine
- Kidney international
- 1 October 2002
BACKGROUND The induction of excess matrix in renal fibrosis seems to be mediated, at least in part, by the transforming growth factor-beta (TGF-beta)-mediated induction of connective tissue growth… Expand
Endothelial to Mesenchymal Transition Contributes to Endothelial Dysfunction in Pulmonary Arterial Hypertension.
Pulmonary arterial hypertension (PAH) is a progressive disease characterized by lung endothelial cell dysfunction and vascular remodeling. Normally, the endothelium forms an integral cellular barrier… Expand
The role of connective tissue growth factor, a multifunctional matricellular protein, in fibroblast biology.
Connective tissue growth factor (CTGF, CCN2), a member of the CCN family of proteins, is a cysteine-rich proadhesive matricellular protein that plays an essential role in the formation of blood… Expand