• Publications
  • Influence
TGF‐β signaling and the fibrotic response
  • A. Leask, D. Abraham
  • Medicine, Biology
  • FASEB journal : official publication of the…
  • 1 May 2004
The cause of fibrotic diseases, pathologies characterized by excessive production, deposition, and contraction of extracellular matrix, is unknown. To understand the molecular basis of fibroticExpand
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Clearing algorithms for barter exchange markets: enabling nationwide kidney exchanges
In barter-exchange markets, agents seek to swap their items with one another, in order to improve their own utilities. These swaps consist of cycles of agents, with each agent receiving the item ofExpand
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All in the CCN family: essential matricellular signaling modulators emerge from the bunker
The CCN family is a group of six secreted proteins that specifically associate with the extracellular matrix. Structurally, CCN proteins are modular, containing up to four distinct functionalExpand
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Popular matchings
In this paper, we give the first polynomial-time algorithms to determine if an instance admits a popular matching, and to find a largest such matching, if one exists, and show that the problem has equivalent time complexity to the maximum-cardinality bipartite matching problem. Expand
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CCN2 is required for bleomycin-induced skin fibrosis in mice.
OBJECTIVE No therapy for fibrotic disease is available. The proadhesive matricellular protein connective tissue growth factor CCN2 is a marker of fibrotic cells; however, the specific role of CCN2 inExpand
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CTGF and SMADs, Maintenance of Scleroderma Phenotype Is Independent of SMAD Signaling*
In normal adult fibroblasts, transforming growth factor-β (TGFβ) induces the expression of connective tissue growth factor (CTGF). CTGF independently promotes fibroblast proliferation and matrixExpand
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Endothelin-1 promotes myofibroblast induction through the ETA receptor via a rac/phosphoinositide 3-kinase/Akt-dependent pathway and is essential for the enhanced contractile phenotype of fibrotic
The endothelins are a family of endothelium-derived peptides that possess a variety of functions, including vasoconstriction. Endothelin-1 (ET-1) is up-regulated during tissue repair and promotesExpand
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CTGF expression in mesangial cells: involvement of SMADs, MAP kinase, and PKC.
BACKGROUND The induction of excess matrix in renal fibrosis seems to be mediated, at least in part, by the transforming growth factor-beta (TGF-beta)-mediated induction of connective tissue growthExpand
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Endothelial to Mesenchymal Transition Contributes to Endothelial Dysfunction in Pulmonary Arterial Hypertension.
Pulmonary arterial hypertension (PAH) is a progressive disease characterized by lung endothelial cell dysfunction and vascular remodeling. Normally, the endothelium forms an integral cellular barrierExpand
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The role of connective tissue growth factor, a multifunctional matricellular protein, in fibroblast biology.
  • A. Leask, D. Abraham
  • Biology, Medicine
  • Biochemistry and cell biology = Biochimie et…
  • 1 November 2003
Connective tissue growth factor (CTGF, CCN2), a member of the CCN family of proteins, is a cysteine-rich proadhesive matricellular protein that plays an essential role in the formation of bloodExpand
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