Skip to search formSkip to main contentSkip to account menu

1,2-dithiol-3-thione

Known as: 1,2-Dithiole-3-Thione, 3H-1,2-dithiole-3-thione, D3T compound 
National Institutes of Health

Related topics

Related topics

4 relations
1,3-Dithiole-2-Thione

Broader (3)

Antineoplastic AgentsThionesThiophenes

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2009
Highly Cited
2009
Inhibition of Arachidonic Acid and Iron-Induced Mitochondrial Dysfunction and Apoptosis by Oltipraz and Novel 1,2-Dithiole-3-thione Congeners
4-Methyl-5-(2-pyrazinyl)-1,2-dithiole-3-thione (oltipraz), a prototype drug candidate containing a 1,2-dithiole-3-thione moiety… 
2009
2009
Upregulation of cellular glutathione by 3H-1,2-dithiole-3-thione as a possible treatment strategy for protecting against acrolein-induced neurocytotoxicity.
2006
2006
Identification of novel transcriptional networks in response to treatment with the anticarcinogen 3H-1,2-dithiole-3-thione.
3H-1,2-dithiole-3-thione (D3T), an inducer of antioxidant and phase 2 genes, is known to enhance the detoxification of… 
Highly Cited
2004
Highly Cited
2004
The Transcriptional Response to a Peroxisome Proliferator-activated Receptor α Agonist Includes Increased Expression of Proteome Maintenance Genes*
The nuclear receptor peroxisome proliferator-activated receptor α (PPARα), in addition to regulating lipid homeostasis, controls… 
Highly Cited
2002
Highly Cited
2002
Transcriptional Induction of CYP1A1 by Oltipraz in Human Caco-2 Cells Is Aryl Hydrocarbon Receptor- and Calcium-dependent*
Oltipraz, a synthetic derivative of the cruciferous vegetable product 1,2-dithiole-3-thione, is considered as one of the most… 
Highly Cited
2001
Highly Cited
2001
Modulation of biomarkers by chemopreventive agents in smoke-exposed rats.
Chemoprevention opens new perspectives in the prevention of cancer and other chronic degenerative diseases associated with… 
2000
2000
Chemoprotective 3H-1,2-dithiole-3-thione induces antioxidant genes in vivo.
Highly Cited
1999
Highly Cited
1999
Modulation of in vitro biomarkers of the carcinogenic process by chemopreventive agents.
A structurally diverse group of chemopreventive agents was evaluated using in vitro biomarkers of the carcinogenesis process… 
1996
1996
A comparison of the effect of inducers on the expression of glutathione‐S‐transferases in the liver of the intact rat and in hepatocytes in primary culture
Recently, we used human hepatocytes in primary culture to study the effects of inducers of glutathione‐S‐transferases (GSTs) in… 
Highly Cited
1990
Highly Cited
1990
Transcriptional control of glutathione S-transferase gene expression by the chemoprotective agent 5-(2-pyrazinyl)-4-methyl-1,2-dithiole-3-thione (oltipraz) in rat liver.
The substituted 1,2-dithiole-3-thione oltipraz [5-(2-pyrazinyl)-4-methyl-1,2-dithiole-3-thione] protects against the acute and… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)