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1,2-dithiol-3-thione

Known as: 1,2-Dithiole-3-Thione, 3H-1,2-dithiole-3-thione, D3T compound 
National Institutes of Health

Related topics

Related topics

4 relations
1,3-Dithiole-2-Thione

Broader (3)

Antineoplastic AgentsThionesThiophenes

Papers overview

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Highly Cited
2009
Highly Cited
2009
Inhibition of Arachidonic Acid and Iron-Induced Mitochondrial Dysfunction and Apoptosis by Oltipraz and Novel 1,2-Dithiole-3-thione Congeners
4-Methyl-5-(2-pyrazinyl)-1,2-dithiole-3-thione (oltipraz), a prototype drug candidate containing a 1,2-dithiole-3-thione moiety… 
Highly Cited
2004
Highly Cited
2004
The Transcriptional Response to a Peroxisome Proliferator-activated Receptor α Agonist Includes Increased Expression of Proteome Maintenance Genes*
The nuclear receptor peroxisome proliferator-activated receptor α (PPARα), in addition to regulating lipid homeostasis, controls… 
Review
2001
Review
2001
Role of phase 2 enzyme induction in chemoprotection by dithiolethiones.
Highly Cited
2001
Highly Cited
2001
Modulation of biomarkers by chemopreventive agents in smoke-exposed rats.
Chemoprevention opens new perspectives in the prevention of cancer and other chronic degenerative diseases associated with… 
Highly Cited
1995
Highly Cited
1995
Electrophile and antioxidant regulation of enzymes that detoxify carcinogens.
Detoxication (phase 2) enzymes, such as glutathione S-transferases (GSTs), NAD(P)H:(quinone-acceptor) oxidoreductase (QR), and… 
Highly Cited
1995
Highly Cited
1995
Inhibition of CYP1A2 and CYP3A4 by oltipraz results in reduction of aflatoxin B1 metabolism in human hepatocytes in primary culture.
Dithiolethiones are thought to act as potent chemoprotective agents against aflatoxin B1 (AFB1)-induced hepatocarcinogenesis in… 
Highly Cited
1993
Highly Cited
1993
Preferential increase of glutathione S-transferase class alpha transcripts in cultured human hepatocytes by phenobarbital, 3-methylcholanthrene, and dithiolethiones.
In rodents, a diversity of compounds are able to protect against acute and chronic toxicities of various xenobiotics including… 
Highly Cited
1992
Highly Cited
1992
Potent inhibition of aflatoxin-induced hepatic tumorigenesis by the monofunctional enzyme inducer 1,2-dithiole-3-thione.
1,2-Dithiole-3-thiones are five-membered cyclic sulfur-containing compounds with antioxidant, chemotherapeutic, radioprotective… 
Highly Cited
1990
Highly Cited
1990
Transcriptional control of glutathione S-transferase gene expression by the chemoprotective agent 5-(2-pyrazinyl)-4-methyl-1,2-dithiole-3-thione (oltipraz) in rat liver.
The substituted 1,2-dithiole-3-thione oltipraz [5-(2-pyrazinyl)-4-methyl-1,2-dithiole-3-thione] protects against the acute and… 
Highly Cited
1987
Highly Cited
1987
Mechanism of protection against aflatoxin tumorigenicity in rats fed 5-(2-pyrazinyl)-4-methyl-1,2-dithiol-3-thione (oltipraz) and related 1,2-dithiol-3-thiones and 1,2-dithiol-3-ones.
1,2-Dithiol-3-thiones, reported constituents of cruciferous vegetables, are five-membered cyclic sulfur-containing compounds with… 
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