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Dose-independent pharmacokinetics of metformin in rats: Hepatic and gastrointestinal first-pass effects.
- Young H. Choi, Sang -Geon Kim, M. Lee
- Medicine, BiologyJournal of pharmaceutical sciences
- 1 November 2006
The low F value of metformin in rats was mainly due to considerable gastrointestinal first-pass effects, and factors affecting protein binding of met formin to 4% human serum albumin were also discussed.
Molecular mechanism of nrf2 activation by oxidative stress.
It is reported that PI3-kinase is responsible for the rise of cellular Ca(2+), which is requisite for nuclear translocation of Nrf2 and contributes to antioxidant phase II enzyme induction via coordinate gene transactivation.
AMPK Facilitates Nuclear Accumulation of Nrf2 by Phosphorylating at Serine 550
- M. S. Joo, Won Kim, Ki Young Lee, J. Kim, J. H. Koo, Sang -Geon Kim
- Biology, ChemistryMolecular and Cellular Biology
- 9 May 2016
Taking the data collectively, AMPK phosphorylates Nrf2 at the Ser550 residue, which, in conjunction with AMPK-mediated GSK3β inhibition, promotes nuclear accumulation of NRF2 for antioxidant response element (ARE)-driven gene transactivation.
Phosphatidylinositol 3-kinase regulates nuclear translocation of NF-E2-related factor 2 through actin rearrangement in response to oxidative stress.
- K. Kang, S. J. Lee, Jeong Weon Park, Sang -Geon Kim
- Biology, ChemistryMolecular Pharmacology
- 1 November 2002
It is demonstrated that the PI3-kinase signaling pathway regulates rearrangement of actin microfilaments in response to oxidative stress and that depolymerization of act in causes a complex of Nrf2 bound with actin to translocate into nucleus.
Glutathione S-Transferase Mu Modulates the Stress-activated Signals by Suppressing Apoptosis Signal-regulating Kinase 1*
Apoptosis signal-regulating kinase 1 (ASK1) is a mitogen-activated protein kinase kinase kinase that can activate the c-Jun N-terminal kinase and the p38 signaling pathways. It plays a critical role…
Inhibition of lipopolysaccharide‐inducible nitric oxide synthase, TNF‐α and COX‐2 expression by sauchinone effects on I‐κBα phosphorylation, C/EBP and AP‐1 activation
It is demonstrated that sauchinone inhibits LPS‐inducible iNOS, TNF‐α and COX‐2 expression in macrophages through suppression of I‐κBα phosphorylation and p65 nuclear translocation and of C/EBP and/or AP‐1 activation, which may constitute anti‐inflammatory effects of the lignan.
Role of adenosine monophosphate‐activated protein kinase–p70 ribosomal S6 kinase‐1 pathway in repression of liver X receptor‐alpha–dependent lipogenic gene induction and hepatic steatosis by a novel…
- Seong Hwan Hwahng, S. Ki, E. Bae, Hyun Eun Kim, Sang -Geon Kim
- Biology, ChemistryHepatology
- 1 June 2009
Oltipraz was found to inhibit hepatic triglyceride accumulation and lipogenic gene induction in mice fed a high‐fat diet and led to the identification of S6K1 as a particularly attractive target for intervention in hepatic steatosis.
Inhibition of Arachidonic Acid and Iron-Induced Mitochondrial Dysfunction and Apoptosis by Oltipraz and Novel 1,2-Dithiole-3-thione Congeners
It is demonstrated that oltipraz and new 1,2-dithiole-3-thiones are capable of protecting cells from AA + iron-induced ROS production and mitochondrial dysfunction, which may be associated with AMPK activation.
Roles of toll-like receptors in Cancer: A double-edged sword for defense and offense
- S. Basith, Balachandran Manavalan, T. Yoo, Sang -Geon Kim, Sangdun Choi
- BiologyArchives of pharmacal research
- 1 September 2012
The dual roles ofTLRs in tumor cells are summarized and the therapeutic potential of TLRs in the context of tumorigenesis is delved into.