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(11C)N-desmethyl-loperamide

Known as: (11C)dLop, Carbon C 11 N-desmethyl-Loperamide 
A radiopharmaceutical containing N-desmethyl loperamide (dLop) labeled with carbon 11 (11C), used to measure the activity of efflux transporter P… 
National Institutes of Health

Related topics

Related topics

2 relations
NCIt Antineoplastic Agent Terminology

Broader (1)

Radioconjugate

Papers overview

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Highly Cited
2018
Highly Cited
2018
Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2D6 and Tamoxifen Therapy
Tamoxifen is biotransformed by CYP2D6 to 4‐hydroxytamoxifen and 4‐hydroxy N‐desmethyl tamoxifen (endoxifen), both with greater… 
Highly Cited
2015
Highly Cited
2015
Occurrence and removal of frequently prescribed pharmaceuticals and corresponding metabolites in wastewater of a sewage treatment plant.
Highly Cited
2008
Highly Cited
2008
Synthesis and evaluation in monkey of two sensitive 11C-labeled aryloxyanilide ligands for imaging brain peripheral benzodiazepine receptors in vivo.
We sought to develop (11)C-labeled ligands for sensitive imaging of brain peripheral benzodiazepine receptors (PBR) in vivo. Two… 
Highly Cited
2008
Highly Cited
2008
11C-Loperamide and Its N-Desmethyl Radiometabolite Are Avid Substrates for Brain Permeability-Glycoprotein Efflux
Loperamide, an opiate receptor agonist, does not cross the blood–brain barrier because it is a substrate for the permeability… 
Highly Cited
2003
Highly Cited
2003
Gemfibrozil considerably increases the plasma concentrations of rosiglitazone
Aims/hypothesisOur aim was to investigate possible interaction between gemfibrozil and rosiglitazone, a thiazolidinedione… 
Highly Cited
2001
Highly Cited
2001
Escitalopram (S-citalopram) and its metabolites in vitro: cytochromes mediating biotransformation, inhibitory effects, and comparison to R-citalopram.
Transformation of escitalopram (S-CT), the pharmacologically active S-enantiometer of citalopram, to S-desmethyl-CT (S-DCT), and… 
Highly Cited
2000
Highly Cited
2000
An in vitro model for predicting in vivo inhibition of cytochrome P450 3A4 by metabolic intermediate complex formation.
An in vitro model is proposed to account for the clinically observed inhibition of cytochrome P450 (CYP) 3A that results from… 
Highly Cited
1997
Highly Cited
1997
Role of CYP3A4 in human hepatic diltiazem N-demethylation: inhibition of CYP3A4 activity by oxidized diltiazem metabolites.
The antihypertensive agent diltiazem (DTZ) impairs hepatic drug metabolism by inhibition of cytochrome P450 (CYP). The… 
Highly Cited
1996
Highly Cited
1996
Cytochromes P450, 1A2, and 2C9 are responsible for the human hepatic O-demethylation of R- and S-naproxen.
Highly Cited
1981
Highly Cited
1981
Clinical Pharmacokinetics of Indomethacin
Indomethacin (l-(p-chlorobenzoyl)-5-methoxy-2-methylindole-3-acetic acid) is an anti-inflammatory antipyretic drug commonly used… 
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