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CYP2B6 mediates the in vitro hydroxylation of bupropion: potential drug interactions with other antidepressants.
TLDR
Bupropion hydroxylation is mediated almost exclusively by CYP2B6 and can serve as an index reaction reflecting activity of this isoform and suggest a low inhibitory potency versus CYP 2D6, the clinical importance of which is not established. Expand
Midazolam and triazolam biotransformation in mouse and human liver microsomes: relative contribution of CYP3A and CYP2C isoforms.
TLDR
TRZ hydroxylation appears to be CYP3A specific in mice and humans, demonstrating that metabolic profiles of drugs in animals cannot be assumed to reflect human metabolic patterns, even with closely related substrates. Expand
Effect of Age, Gender, and Obesity on Midazolam Kinetics
TLDR
Midazolam elimination half‐life (t1/2) after iv dosage was significantly prolonged in elderly (aged 60‐74 yr) versus young (24‐33 yr) males and in obese subjects (8.4 vs. 2.7, P < 0.001) and Vd was greater in the obese subjects even after correction for total weight, indicating disproportionate distribution of midAZolam into adipose weight. Expand
Metabolism of the antidepressant mirtazapine in vitro: contribution of cytochromes P-450 1A2, 2D6, and 3A4.
TLDR
Induction/inhibition or genetic polymorphisms of CYP2D6, CYP1A2, and CYP3A4 may affect MIR metabolism, but involvement of several enzymes in different metabolic pathways may prevent large alterations in in vivo drug clearance. Expand
O- and N-demethylation of Venlafaxine In Vitro by Human Liver Microsomes and by Microsomes from cDNA-Transfected Cells: Effect of Metabolic Inhibitors and SSRI Antidepressants
TLDR
Results are consistent with previous studies that show CYP2D6 and −3A4 play important roles in the formation of ODV and NDV, respectively and it is shown that several other CYPs have important role in the biotransformation of VF. Expand
Pharmacokinetics of Diphenhydramine and a Demethylated Metabolite Following Intravenous And Oral Administration
TLDR
Kinetics of diphenhydramine (DP) hydrochloride and a major demethylated metabolite (DMDP) were determined from multiple plasma samples drawn during a 24‐ to 48‐hour period after dosage using a gas chromatographic technique. Expand
Ritonavir, efavirenz, and nelfinavir inhibit CYP2B6 activity in vitro: potential drug interactions with bupropion.
TLDR
The inhibition of bupropion hydroxylation in vitro by nelfinavir, ritonavir, and efavirenz indicates inhibitory potency versus CYP2B6 and suggests the potential for clinical drug interactions. Expand
Inhibition of Human Cytochrome P450 Isoforms by Nonnucleoside Reverse Transcriptase Inhibitors
TLDR
In vitro microsomal model provides relevant predictive data on probable drug interactions with NNRTIs when the mechanism is inhibition of CYP‐mediated drug biotransformation, however, the model does not incorporate interactions attributable to enzyme induction. Expand
Population Pharmacokinetics of Methylphenidate in Children with Attention‐Deficit Hyperactivity Disorder
TLDR
The relatively noninvasive approach used in this study allows the assessment of pharmacokinetic properties of medications under conditions of appropriate clinical use in special populations such as children, adolescents, and the elderly. Expand
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