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Fumaric acid esters exert neuroprotective effects in neuroinflammation via activation of the Nrf2 antioxidant pathway.

The ability of dimethylfumarate to activate nuclear factor (erythroid-derived 2)-related factor 2 may offer a novel cytoprotective modality that further augments the natural antioxidant responses in multiple sclerosis tissue and is not yet targeted by other multiple sclerosis therapies.
PubMed (opens in a new tab)

Regulation of Integrin Function by the Urokinase Receptor

The urokinase-type plasminogen activator receptor (uPAR) and integrins formed stable complexes that both inhibited native integrin adhesive function and promoted adhesion to vitronectin via a ligand binding site on uPAR.
AAAS (opens in a new tab)

Fumarates Promote Cytoprotection of Central Nervous System Cells against Oxidative Stress via the Nuclear Factor (Erythroid-Derived 2)-Like 2 Pathway

DMF and MMF are cytoprotective for neurons and astrocytes against oxidative stress-induced cellular injury and loss, potentially via up-regulation of an Nrf2-dependent antioxidant response, and these data suggest DMF andMMF may function through improving mitochondrial function.
Publisher (opens in a new tab)

ECM signalling: orchestrating cell behaviour and misbehaviour.

PubMed (opens in a new tab)

Small molecules inhibit the interaction of Nrf2 and the Keap1 Kelch domain through a non-covalent mechanism.

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Perturbation of β1‐integrin function alters the development of murine mammary gland

Observations prove that in vivo, β1‐integrins are involved in control of proliferation, apoptosis, differentiation and maintenance of baso‐apical polarity of mammary epithelial cells, and therefore are essential for normal mammary gland development and function.
Wiley (opens in a new tab)

Disruption of integrin function and induction of tyrosine phosphorylation by the autonomously expressed beta 1 integrin cytoplasmic domain.

Results demonstrate that the autonomously expressed beta 1 integrin cytoplasmic domain can act as a trans-dominant inhibitor of integrin function, presumably via competitive interactions with cytop lasmic components that are required for integrin-mediated cell adhesion and tyrosine phosphorylation.
PubMed (opens in a new tab)

TRAF3 Controls Activation of the Canonical and Alternative NFκB by the Lymphotoxin Beta Receptor

Modulation of cellular TRAF3 levels may contribute to regulation of NFκB-dependent gene expression by LTBR by affecting the balance of LTBR-dependent activation of canonical and non-canonicalNFκB pathways.
ASBMB (opens in a new tab)

Alphav beta6 integrin regulates renal fibrosis and inflammation in Alport mouse.

It is demonstrated that alpha v beta6 can contribute to the regulation of renal fibrosis and suggest this integrin as a potential therapeutic target.
PubMed (opens in a new tab)

Partial inhibition of integrin alpha(v)beta6 prevents pulmonary fibrosis without exacerbating inflammation.

The elevated expression of alpha(v) beta6, an activator of the fibrogenic cytokine, TGF-beta, in human pulmonary fibrosis suggests that alpha( v)beta6 monoclonal antibodies could represent a promising new therapeutic strategy for treating pulmonary fibrot.
PubMed (opens in a new tab)
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