Alphav beta6 integrin regulates renal fibrosis and inflammation in Alport mouse.

  title={Alphav beta6 integrin regulates renal fibrosis and inflammation in Alport mouse.},
  author={Kyungmin Hahm and Matvey E. Lukashev and Yi Luo and William J Yang and Brian M. Dolinski and Paul H Weinreb and Kenneth J. Simon and Li Chun Wang and Diane R Leone and Roy R. Lobb and Donald J. McCrann and Normand E. Allaire and Gerald S. B. Horan and Agnes Fogo and Raghu Kalluri and Charles F Shield and Dean Sheppard and Humphrey A. Gardner and Shelia M. Violette},
  journal={The American journal of pathology},
  volume={170 1},
The transforming growth factor (TGF)-beta-inducible integrin alpha v beta6 is preferentially expressed at sites of epithelial remodeling and has been shown to bind and activate latent precursor TGF-beta. Herein, we show that alpha v beta6 is overexpressed in human kidney epithelium in membranous glomerulonephritis, diabetes mellitus, IgA nephropathy, Goodpasture's syndrome, and Alport syndrome renal epithelium. To assess the potential regulatory role of alpha v beta6 in renal disease, we… CONTINUE READING


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